1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/gt.2012.32" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/gt.2012.32</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
583-587
Issue
6
Volume
19
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
SDF-1 in myocardial repair
Publisher
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Gene Therapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
acute myocordial infarction; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; chemokines; gene-therapy; Genetics & Heredity; Heart failure; infarction; ischemic cardiomyopathy; mesenchymal stem-cells; pilot trial; regeneration; Regenerative medicine; Research & Experimental Medicine; stem-cells
Creator
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Penn M S; Pastore J; Miller T; Aras R
Description
An account of the resource
Stem cell therapy for the prevention and treatment of cardiac dysfunction holds significant promise for patients with ischemic heart disease. Excitingly early clinical studies have demonstrated safety and some clinical feasibility, while at the same time studies in the laboratory have investigated mechanisms of action and strategies to optimize the effects of regenerative cardiac therapies. One of the key pathways that has been demonstrated critical in stem cell-based cardiac repair is (stromal cell-derived factor-1) SDF-1:CXCR4. SDF-1:CXCR4 has been shown to affect stem cell homing, cardiac myocyte survival and ventricular remodeling in animal studies of acute myocardial infarction and chronic heart failure. Recently released clinical data suggest that SDF-1 alone is sufficient to induce cardiac repair. Most importantly, studies like those on the SDF-1:CXCR4 axis have suggested mechanisms critical for cardiac regenerative therapies that if clinical investigators continue to ignore will result in poorly designed studies that will continue to yield negative results. Gene Therapy (2012) 19, 583-587; doi:10.1038/gt.2012.32
Identifier
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<a href="http://doi.org/10.1038/gt.2012.32" target="_blank" rel="noreferrer noopener">10.1038/gt.2012.32</a>
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Journal Article
2012
acute myocordial infarction
Aras R
Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
chemokines
gene therapy
gene-therapy
Genetics & Heredity
Heart failure
Infarction
ischemic cardiomyopathy
Journal Article
mesenchymal stem-cells
Miller T
Pastore J
Penn M S
pilot trial
Regeneration
Regenerative Medicine
Research & Experimental Medicine
stem-cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/10837450.2015.1041043" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/10837450.2015.1041043</a>
Pages
647–654
Issue
6
Volume
21
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Gelucire-stabilized nanoparticles as a potential DNA delivery system.
Publisher
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Pharmaceutical development and technology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
Humans; Animals; Mice; nanoparticles; Cell Line; Hep G2 Cells; gene therapy; *Gene Transfer Techniques; Cationic lipids; Cell Survival/drug effects/physiology; DNA/*administration & dosage/chemistry; macrophage activation; Macrophages/drug effects/physiology; Nanoparticles/*administration & dosage/chemistry; Polyethylene Glycols/*administration & dosage/chemistry; transfection
Creator
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Oyewumi Moses O; Wehrung Daniel; Sadana Prabodh
Description
An account of the resource
Clinical viability of gene delivery systems has been greatly impacted by potential toxicity of the delivery systems. Recently, we reported the nanoparticle (NP) preparation process that employs biocompatible materials such as Gelucire(R) 44/14 and cetyl alcohol as matrix materials. In the current study, the NP preparation was modified for pDNA loading through: (i) inclusion of cationic lipids (DOTAP or DDAB) with NP matrix materials; or (ii) application of cationic surfactants (CTAB) to generate NPs with desired surface charges for pDNA complexation. Colloidal stability and efficiency of loading pGL3-DR4X2-luciferase plasmid DNA in NPs were verified by gel permeation chromatography. Compared to pDNA alone, all the NPs were effective in preserving pDNA from digestion by DNase. While pDNA loading using CTAB-NPs involved fewer steps compared to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/10837450.2015.1041043" target="_blank" rel="noreferrer noopener">10.3109/10837450.2015.1041043</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Transfer Techniques
2016
Animals
Cationic lipids
Cell Line
Cell Survival/drug effects/physiology
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
DNA/*administration & dosage/chemistry
gene therapy
Hep G2 Cells
Humans
macrophage activation
Macrophages/drug effects/physiology
Mice
Nanoparticles
Nanoparticles/*administration & dosage/chemistry
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Oyewumi Moses O
Pharmaceutical development and technology
Polyethylene Glycols/*administration & dosage/chemistry
Sadana Prabodh
Transfection
Wehrung Daniel
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.18632/genesandcancer.62" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/genesandcancer.62</a>
Pages
220–230
Issue
5
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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CArG-driven GADD45alpha activated by resveratrol inhibits lung cancer cells.
Publisher
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Genes & cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-05
Subject
The topic of the resource
CArG elements; Egr-1; GADD45a; gene therapy; resveratrol; synthetic promoters
Creator
An entity primarily responsible for making the resource
Shi Qiwen; Geldenhuys Werner; Sutariya Vijaykumar; Bishayee Anupam; Patel Isha; Bhatia Deepak
Description
An account of the resource
We report anticarcinogenic effects of suicide gene therapy that relies on the use of resveratrol-responsive CArG elements from the Egr-1 promoter to induce GADD45alpha. In A549 lung cancer cells, endogenous GADD45alpha was not induced upon resveratrol treatment. Therefore, induction of exogenous GADD45alpha resulted in growth inhibition. Resveratrol transiently induced Egr-1 through ERK/JNK-ElK-1. Hence, we cloned natural or synthetic Egr-1 promoter upstream of GADD45alpha cDNA to create a suicide gene therapy vector. Since natural promoter may have antagonized effects, we tested synthetic promoter that contains either five, six or nine repeats of CArG elements essential in the Egr-1 promoter to drive the expression of GADD45alpha upon resveratrol treatment. Further analysis confirmed that both synthetic promoter and natural Egr-1 promoter were able to "turn on" the expression of GADD45alpha when combined with resveratrol, and subsequently led to suppression of cell proliferation and apoptosis.
Identifier
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<a href="http://doi.org/10.18632/genesandcancer.62" target="_blank" rel="noreferrer noopener">10.18632/genesandcancer.62</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Bhatia Deepak
Bishayee Anupam
CArG elements
Egr-1
GADD45a
Geldenhuys Werner
gene therapy
Genes & cancer
Patel Isha
Resveratrol
Shi Qiwen
Sutariya Vijaykumar
synthetic promoters