1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.M112.375907" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.M112.375907</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
25123-25138
Issue
30
Volume
287
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activation Of The Farnesoid X Receptor Induces Hepatic Expression And Secretion Of Fibroblast Growth Factor 21
Publisher
An entity responsible for making the resource available
Journal of Biological Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-07
Subject
The topic of the resource
bile-acids; Biochemistry & Molecular Biology; fatty-acid synthesis; gene-expression; glucagon-like peptide-1; glucose-homeostasis; insulin-resistance; metabolic regulator; nuclear receptor; ppar-alpha; primary rat hepatocytes
Creator
An entity primarily responsible for making the resource
Cyphert H A; Ge X M; Kohan A B; Salati L M; Zhang Y Q; Hillgartner F B
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.M112.375907" target="_blank" rel="noreferrer noopener">10.1074/jbc.M112.375907</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
bile-acids
Biochemistry & Molecular Biology
Cyphert H A
fatty-acid synthesis
Ge X M
gene-expression
glucagon-like peptide-1
glucose-homeostasis
Hillgartner F B
insulin-resistance
Journal of Biological Chemistry
Kohan A B
metabolic regulator
Nuclear Receptor
PPAR-alpha
primary rat hepatocytes
Salati L M
Zhang Y Q
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">http://doi.org/10.21037/hbsn.2019.09.03</a>
Pages
152-169
Issue
2
Volume
9
ISSN
2304-3881 2304-3881
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.21037/hbsn.2019.09.03</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.
Publisher
An entity responsible for making the resource available
Hepatobiliary surgery and nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
alcoholic liver disease (ALD); bacterial translocation; Bile acid; binding protein; farnesoid X receptor (FXR); farnesoid-x-receptor; fatty liver; glucagon-like peptide-1; growth-factor 19; gut microbiota; microbiota; molecular-cloning; non-alcoholic steatohepatitis (NASH); non-alcoholic steatohepatitis (NASH); nuclear receptor; solute transporter-alpha
Creator
An entity primarily responsible for making the resource
Li Tiangang; Chiang John Y L
Description
An account of the resource
Bile acids are synthesized from cholesterol only in hepatocytes. Bile acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins in small intestine. Bile acids are signaling molecules that activate nuclear receptor farnesoid X receptor (FXR) and cell surface G protein-coupled receptor TGR5. FXR critically regulates bile acid homeostasis by mediating bile acid feedback inhibition of hepatic bile acid synthesis. In addition, bile acid-activated cellular signaling pathways regulate metabolic homeostasis, immunity, and cell proliferation in various metabolically active organs. In the small and large intestine, gut bacterial enzymes modify primary bile acids to generate secondary bile acids to help shape the bile acid pool composition and subsequent biological effects. In turn, bile acids exhibit anti-microbial properties and modulate gut microbiota to influence host metabolism and immunity. Currently, bile acid-based therapies including systemic and intestine-restricted FXR agonists, TGR5 agonists, fibroblast growth factor 19 analogue, intestine FXR antagonists, and intestine apical sodium-bile acid transporter (ASBT) inhibitors have been developed as promising treatments for non-alcoholic steatohepatitis (NASH). These pharmacological agents improved metabolic and inflammatory disorders via distinct mechanisms of action that are subjects of extensive research interest. More recently, human and experimental alcoholic liver disease (ALD) has been associated with disrupted bile acid homeostasis. In additional, new findings showed that targeting bile acid metabolism and signaling may be promising therapeutic approaches for treating ALD.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">10.21037/hbsn.2019.09.03</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
alcoholic liver disease (ALD)
Bacterial Translocation
bile acid
binding protein
Chiang John Y L
Department of Integrative Medical Sciences
farnesoid X receptor (FXR)
farnesoid-x-receptor
Fatty Liver
glucagon-like peptide-1
growth-factor 19
gut microbiota
Hepatobiliary surgery and nutrition
Journal Article
journalArticle
June 2020 Update I
Li Tiangang
Microbiota
molecular-cloning
NEOMED College of Medicine
non-alcoholic steatohepatitis (NASH)
Nuclear Receptor
solute transporter-alpha