1
40
2
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Text
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<a href="https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-43-257.pdf" target="_blank" rel="noreferrer noopener">http://doi.org/10.4093/dmj.2019.0043</a>
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Pages
257-272
Issue
3
Volume
43
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Title
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Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Publisher
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Diabetes & Metabolism Journal
Date
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2019
2019-06
Subject
The topic of the resource
BILE acids; Bile acids and salts; cholesterol 7-alpha-hydroxylase; Cytoplasmic and Nuclear; Endocrinology & Metabolism; FARNESOID X receptor; farnesoid-x-receptor; FATTY liver; fatty liver-disease; G protein coupled receptors; G-protein-coupled; Gastrointestinal microbiome; growth-factor 19; gut microbiota; hepatic steatosis; improves insulin sensitivity; liver disease; metabolic; Non-alcoholic fatty; Non-alcoholic Fatty Liver Disease; nuclear; receptor; Receptors; serum fgf21 levels; syndrome
Creator
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Ferrell Jessica M; Chiang John Y L
Description
An account of the resource
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and nonalcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.4093/dmj.2019.0043" target="_blank" rel="noreferrer noopener">10.4093/dmj.2019.0043</a>
2019
BILE acids
Bile Acids and Salts
Chiang John Y L
cholesterol 7-alpha-hydroxylase
Cytoplasmic and Nuclear
Department of Integrative Medical Sciences
Diabetes & Metabolism Journal
Endocrinology & Metabolism
Farnesoid X receptor
farnesoid-x-receptor
Fatty Liver
fatty liver-disease
Ferrell Jessica M
G protein coupled receptors
G-protein-coupled
Gastrointestinal Microbiome
growth-factor 19
gut microbiota
hepatic steatosis
improves insulin sensitivity
Liver disease
Metabolic
NEOMED College of Medicine
Non-alcoholic fatty
Non-alcoholic Fatty Liver Disease
nuclear
Receptor
Receptors
September 2019 Update
serum fgf21 levels
Syndrome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">http://doi.org/10.21037/hbsn.2019.09.03</a>
Pages
152-169
Issue
2
Volume
9
ISSN
2304-3881 2304-3881
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.21037/hbsn.2019.09.03</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.
Publisher
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Hepatobiliary surgery and nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
alcoholic liver disease (ALD); bacterial translocation; Bile acid; binding protein; farnesoid X receptor (FXR); farnesoid-x-receptor; fatty liver; glucagon-like peptide-1; growth-factor 19; gut microbiota; microbiota; molecular-cloning; non-alcoholic steatohepatitis (NASH); non-alcoholic steatohepatitis (NASH); nuclear receptor; solute transporter-alpha
Creator
An entity primarily responsible for making the resource
Li Tiangang; Chiang John Y L
Description
An account of the resource
Bile acids are synthesized from cholesterol only in hepatocytes. Bile acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins in small intestine. Bile acids are signaling molecules that activate nuclear receptor farnesoid X receptor (FXR) and cell surface G protein-coupled receptor TGR5. FXR critically regulates bile acid homeostasis by mediating bile acid feedback inhibition of hepatic bile acid synthesis. In addition, bile acid-activated cellular signaling pathways regulate metabolic homeostasis, immunity, and cell proliferation in various metabolically active organs. In the small and large intestine, gut bacterial enzymes modify primary bile acids to generate secondary bile acids to help shape the bile acid pool composition and subsequent biological effects. In turn, bile acids exhibit anti-microbial properties and modulate gut microbiota to influence host metabolism and immunity. Currently, bile acid-based therapies including systemic and intestine-restricted FXR agonists, TGR5 agonists, fibroblast growth factor 19 analogue, intestine FXR antagonists, and intestine apical sodium-bile acid transporter (ASBT) inhibitors have been developed as promising treatments for non-alcoholic steatohepatitis (NASH). These pharmacological agents improved metabolic and inflammatory disorders via distinct mechanisms of action that are subjects of extensive research interest. More recently, human and experimental alcoholic liver disease (ALD) has been associated with disrupted bile acid homeostasis. In additional, new findings showed that targeting bile acid metabolism and signaling may be promising therapeutic approaches for treating ALD.
Identifier
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<a href="http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">10.21037/hbsn.2019.09.03</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
alcoholic liver disease (ALD)
Bacterial Translocation
bile acid
binding protein
Chiang John Y L
Department of Integrative Medical Sciences
farnesoid X receptor (FXR)
farnesoid-x-receptor
Fatty Liver
glucagon-like peptide-1
growth-factor 19
gut microbiota
Hepatobiliary surgery and nutrition
Journal Article
journalArticle
June 2020 Update I
Li Tiangang
Microbiota
molecular-cloning
NEOMED College of Medicine
non-alcoholic steatohepatitis (NASH)
Nuclear Receptor
solute transporter-alpha