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Text
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URL Address
<a href="http://doi.org/10.1152/japplphysiol.00429.2003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/japplphysiol.00429.2003</a>
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Pages
2134-2141
Issue
5
Volume
95
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Title
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Invited review: Role of mechanophysiology in aging of ECM: effects of changes in mechanochemical transduction
Publisher
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Journal of Applied Physiology
Date
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2003
2003-11
Subject
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age; apoptosis; collagen; connective tissue; dermal fibroblasts; expansion; extracellular-matrix; gene-expression; growth-factor responsiveness; guinea-pig; human articular chondrocytes; mechanical forces; mechanical strain; phosphorelay system; Physiology; silicone implant; skin; Sport Sciences; tissue
Creator
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Silver F H; DeVore D; Siperko L M
Description
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Mechanical forces play a role in the development and evolution of extracellular matrices (ECMs) found in connective tissue. Gravitational forces acting on mammalian tissues increase the net muscle forces required for movement of vertebrates. As body mass increases during development, musculoskeletal tissues and other ECMs are able to adapt their size to meet the increased mechanical requirements. However, the control mechanisms that allow for rapid growth in tissue size during development are altered during maturation and aging. The purpose of this mini-review is to examine the relationship between mechanical loading and cellular events that are associated with downregulation of mechanochemical transduction, which appears to contribute to aging of connective tissue. These changes result from decreases in growth factor and hormone levels, as well as decreased activation of the phosphorelay system that controls cell division, gene expression, and protein synthesis. Studies pertaining to the interactions among mechanical forces, growth factors, hormones, and their receptors will better define the relationship between mechanochemical transduction processes and cellular behavior in aging tissues.
Identifier
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<a href="http://doi.org/10.1152/japplphysiol.00429.2003" target="_blank" rel="noreferrer noopener">10.1152/japplphysiol.00429.2003</a>
Format
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Journal Article
2003
Age
Apoptosis
Collagen
connective tissue
dermal fibroblasts
DeVore D
expansion
extracellular-matrix
gene-expression
growth-factor responsiveness
guinea-pig
human articular chondrocytes
Journal Article
Journal of Applied Physiology
mechanical forces
mechanical strain
phosphorelay system
Physiology
silicone implant
Silver F H
Siperko L M
Skin
Sport Sciences
tissue