1
40
5
-
Text
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URL Address
<a href="http://doi.org/10.12688/f1000research.12449.1" target="_blank" rel="noreferrer noopener">http://doi.org/10.12688/f1000research.12449.1</a>
Pages
2029–2029
Volume
6
Dublin Core
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Title
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Recent advances in understanding bile acid homeostasis.
Publisher
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F1000Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-07
Subject
The topic of the resource
Bile acid synthesis; gut microbiota; metabolic regulation
Creator
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Chiang John Y L
Description
An account of the resource
Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, also known as TGR5) to maintain metabolic homeostasis and protect liver and other tissues and cells from bile acid toxicity. Bile acid homeostasis is regulated by a complex mechanism of feedback and feedforward regulation that is not completely understood. This review will cover recent advances in bile acid signaling and emerging concepts about the classic and alternative bile acid synthesis pathway, bile acid composition and bile acid pool size, and intestinal bile acid signaling and gut microbiome in regulation of bile acid homeostasis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.12688/f1000research.12449.1" target="_blank" rel="noreferrer noopener">10.12688/f1000research.12449.1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Bile acid synthesis
Chiang John Y L
Department of Integrative Medical Sciences
F1000Research
gut microbiota
metabolic regulation
NEOMED College of Medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3920/BM2016.0225" target="_blank" rel="noreferrer noopener">http://doi.org/10.3920/BM2016.0225</a>
Pages
71–86
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of antibiotic, probiotic, and human rotavirus infection on colonisation dynamics of defined commensal microbiota in a gnotobiotic pig model.
Publisher
An entity responsible for making the resource available
Beneficial microbes
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
Animals; Severity of Illness Index; gut microbiota; *Germ-Free Life; Anti-Bacterial Agents/administration & dosage; Bifidobacterium longum/drug effects; Biodiversity; ciprofloxacin; Ciprofloxacin/administration & dosage/*pharmacology; Diarrhea/microbiology/physiopathology; Escherichia coli Nissle; Escherichia coli/*growth & development; Feces/microbiology; gnotobiotic pigs; Intestines/*drug effects/microbiology/pathology/physiopathology; Microbiota/*drug effects/physiology; Probiotics/administration & dosage/*pharmacology; rotavirus; Rotavirus Infections/*microbiology/physiopathology/virology; Swine; Virus Shedding/drug effects; Biological; Models; Microbial; Colony Count
Creator
An entity primarily responsible for making the resource
Huang H-C; Vlasova A N; Kumar A; Kandasamy S; Fischer D D; Deblais L; Paim F C; Langel S N; Alhamo M A; Rauf A; Shao L; Saif L J; Rajashekara G
Description
An account of the resource
We developed a gnotobiotic (Gn) pig model colonised with defined commensal microbiota (DMF) to provide a simplified and controlled system to study the interactions between intestinal commensals, antibiotics (ciprofloxacin, CIP), probiotics (Escherichia coli Nissle 1917, EcN) and virulent human rotavirus (VirHRV). The DMF included seven gut commensal species of porcine origin that mimic the predominant species in the infant gut. Gn piglets were divided into four groups: DMF control (non-treated), DMF+CIP (CIP treated), DMF+CIP+EcN (CIP/EcN treated), DMF+EcN (EcN treated) and inoculated orally with 10(5) cfu of each DMF strain. The pig gut was successfully colonised by all DMF species and established a simplified bacterial community by post-bacteria colonisation day (PBCD) 14/post-VirHRV challenge day (PCD) 0. Overall, Bifidobacterium adolescentis was commonly observed in faeces in all groups and time points. At PCD0, after six days of CIP treatment (DMF+CIP), we observed significantly decreased aerobic and anaerobic bacteria counts especially in jejunum (P\textless0.001), where no DMF species were detected in jejunum by T-RFLP. Following HRV challenge, 100% of pigs in DMF+CIP group developed diarrhoea with higher diarrhoea scores and duration as compared to all other groups. However, only 33% of pigs treated with EcN plus CIP developed diarrhoea. EcN treatment also enhanced the bacterial diversity and all seven DMF species were detected with a higher proportion of Bifidobacterium longum in jejunum in the DMF+CIP+EcN group on PBCD14/PCD0. Our results suggest that EcN increased the proportion of B. longum especially in jejunum and mitigated adverse impacts of antibiotic use during acute-infectious diarrhoea. The DMF model with a simplified gut commensal community can further our knowledge of how commensals and probiotics promote intestinal homeostasis and contribute to host health.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3920/BM2016.0225" target="_blank" rel="noreferrer noopener">10.3920/BM2016.0225</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Germ-Free Life
2018
Alhamo M A
Animals
Anti-Bacterial Agents/administration & dosage
Beneficial microbes
Bifidobacterium longum/drug effects
Biodiversity
Biological
ciprofloxacin
Ciprofloxacin/administration & dosage/*pharmacology
Colony Count
Deblais L
Diarrhea/microbiology/physiopathology
Escherichia coli Nissle
Escherichia coli/*growth & development
Feces/microbiology
Fischer D D
gnotobiotic pigs
gut microbiota
Huang H-C
Intestines/*drug effects/microbiology/pathology/physiopathology
Kandasamy S
Kumar A
Langel S N
Microbial
Microbiota/*drug effects/physiology
Models
Paim F C
Probiotics/administration & dosage/*pharmacology
Rajashekara G
Rauf A
rotavirus
Rotavirus Infections/*microbiology/physiopathology/virology
Saif L J
Severity of Illness Index
Shao L
Swine
Virus Shedding/drug effects
Vlasova A N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-43-257.pdf" target="_blank" rel="noreferrer noopener">http://doi.org/10.4093/dmj.2019.0043</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
257-272
Issue
3
Volume
43
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Publisher
An entity responsible for making the resource available
Diabetes & Metabolism Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
BILE acids; Bile acids and salts; cholesterol 7-alpha-hydroxylase; Cytoplasmic and Nuclear; Endocrinology & Metabolism; FARNESOID X receptor; farnesoid-x-receptor; FATTY liver; fatty liver-disease; G protein coupled receptors; G-protein-coupled; Gastrointestinal microbiome; growth-factor 19; gut microbiota; hepatic steatosis; improves insulin sensitivity; liver disease; metabolic; Non-alcoholic fatty; Non-alcoholic Fatty Liver Disease; nuclear; receptor; Receptors; serum fgf21 levels; syndrome
Creator
An entity primarily responsible for making the resource
Ferrell Jessica M; Chiang John Y L
Description
An account of the resource
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and nonalcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.4093/dmj.2019.0043" target="_blank" rel="noreferrer noopener">10.4093/dmj.2019.0043</a>
2019
BILE acids
Bile Acids and Salts
Chiang John Y L
cholesterol 7-alpha-hydroxylase
Cytoplasmic and Nuclear
Department of Integrative Medical Sciences
Diabetes & Metabolism Journal
Endocrinology & Metabolism
Farnesoid X receptor
farnesoid-x-receptor
Fatty Liver
fatty liver-disease
Ferrell Jessica M
G protein coupled receptors
G-protein-coupled
Gastrointestinal Microbiome
growth-factor 19
gut microbiota
hepatic steatosis
improves insulin sensitivity
Liver disease
Metabolic
NEOMED College of Medicine
Non-alcoholic fatty
Non-alcoholic Fatty Liver Disease
nuclear
Receptor
Receptors
September 2019 Update
serum fgf21 levels
Syndrome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">http://doi.org/10.21037/hbsn.2019.09.03</a>
Pages
152-169
Issue
2
Volume
9
ISSN
2304-3881 2304-3881
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.21037/hbsn.2019.09.03</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.
Publisher
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Hepatobiliary surgery and nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
alcoholic liver disease (ALD); bacterial translocation; Bile acid; binding protein; farnesoid X receptor (FXR); farnesoid-x-receptor; fatty liver; glucagon-like peptide-1; growth-factor 19; gut microbiota; microbiota; molecular-cloning; non-alcoholic steatohepatitis (NASH); non-alcoholic steatohepatitis (NASH); nuclear receptor; solute transporter-alpha
Creator
An entity primarily responsible for making the resource
Li Tiangang; Chiang John Y L
Description
An account of the resource
Bile acids are synthesized from cholesterol only in hepatocytes. Bile acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins in small intestine. Bile acids are signaling molecules that activate nuclear receptor farnesoid X receptor (FXR) and cell surface G protein-coupled receptor TGR5. FXR critically regulates bile acid homeostasis by mediating bile acid feedback inhibition of hepatic bile acid synthesis. In addition, bile acid-activated cellular signaling pathways regulate metabolic homeostasis, immunity, and cell proliferation in various metabolically active organs. In the small and large intestine, gut bacterial enzymes modify primary bile acids to generate secondary bile acids to help shape the bile acid pool composition and subsequent biological effects. In turn, bile acids exhibit anti-microbial properties and modulate gut microbiota to influence host metabolism and immunity. Currently, bile acid-based therapies including systemic and intestine-restricted FXR agonists, TGR5 agonists, fibroblast growth factor 19 analogue, intestine FXR antagonists, and intestine apical sodium-bile acid transporter (ASBT) inhibitors have been developed as promising treatments for non-alcoholic steatohepatitis (NASH). These pharmacological agents improved metabolic and inflammatory disorders via distinct mechanisms of action that are subjects of extensive research interest. More recently, human and experimental alcoholic liver disease (ALD) has been associated with disrupted bile acid homeostasis. In additional, new findings showed that targeting bile acid metabolism and signaling may be promising therapeutic approaches for treating ALD.
Identifier
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<a href="http://doi.org/10.21037/hbsn.2019.09.03" target="_blank" rel="noreferrer noopener">10.21037/hbsn.2019.09.03</a>
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journalArticle
2020
alcoholic liver disease (ALD)
Bacterial Translocation
bile acid
binding protein
Chiang John Y L
Department of Integrative Medical Sciences
farnesoid X receptor (FXR)
farnesoid-x-receptor
Fatty Liver
glucagon-like peptide-1
growth-factor 19
gut microbiota
Hepatobiliary surgery and nutrition
Journal Article
journalArticle
June 2020 Update I
Li Tiangang
Microbiota
molecular-cloning
NEOMED College of Medicine
non-alcoholic steatohepatitis (NASH)
Nuclear Receptor
solute transporter-alpha
-
Hyperlink
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URL
https://doi.org/10.1016/j.pharmthera.2022.108238
Dublin Core
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Title
A name given to the resource
Bile acid metabolism and signaling, the microbiota, and metabolic disease
Creator
An entity primarily responsible for making the resource
Jingwei Cai
Bipin Rimal
Changtao Jiang
John Y L Chiang
Andrew D Patterson
Description
An account of the resource
The diversity, composition, and function of the bacterial community inhabiting the human gastrointestinal tract contributes to host health through its role in producing energy or signaling molecules that regulate metabolic and immunologic functions. Bile acids are potent metabolic and immune signaling molecules synthesized from cholesterol in the liver and then transported to the intestine where they can undergo metabolism by gut bacteria. The combination of host- and microbiota-derived enzymatic activities contribute to the composition of the bile acid pool and thus there can be great diversity in bile acid composition that depends in part on the differences in the gut bacteria species. Bile acids can profoundly impact host metabolic and immunological functions by activating different bile acid receptors to regulate signaling pathways that control a broad range of complex symbiotic metabolic networks, including glucose, lipid, steroid and xenobiotic metabolism, and modulation of energy homeostasis. Disruption of bile acid signaling due to perturbation of the gut microbiota or dysregulation of the gut microbiota-host interaction is associated with the pathogenesis and progression of metabolic disorders. The metabolic and immunological roles of bile acids in human health have led to novel therapeutic approaches to manipulate the bile acid pool size, composition, and function by targeting one or multiple components of the microbiota-bile acid-bile acid receptor axis.
Source
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Pharmacol Ther
. 2022 Sep;237:108238. doi: 10.1016/j.pharmthera.2022.108238. Epub 2022 Jul 2.
Language
A language of the resource
English
2022
bile acid
Bile acid biotransformation
Bile acid-activated receptor
gut microbiota
Metabolic disease.