1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0014-2999(98)00008-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(98)00008-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
207-211
Issue
2
Volume
345
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition Of Striatal Dopamine Transporter Activity By 17 Beta-estradiol
Publisher
An entity responsible for making the resource available
European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
brain; dopamine transporter; estradiol; estrous-cycle; gonadal steroid hormone; h-3 gbr-12935 binding; mptp-induced neurotoxicity; nigrostriatal; nucleus-accumbens; Pharmacology & Pharmacy; progesterone; protein-kinase-c; release; sex-differences; striatal; synaptosome; uptake inhibition; uptake sites
Creator
An entity primarily responsible for making the resource
Disshon K A; Boja J W; Dluzen D E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0014-2999(98)00008-9" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(98)00008-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Boja J W
Brain
Disshon K A
Dluzen D E
Dopamine transporter
estradiol
estrous-cycle
European journal of pharmacology
gonadal steroid hormone
h-3 gbr-12935 binding
mptp-induced neurotoxicity
nigrostriatal
nucleus-accumbens
Pharmacology & Pharmacy
progesterone
protein-kinase-c
release
sex-differences
striatal
synaptosome
uptake inhibition
uptake sites
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
9-17
Issue
1
Volume
30
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Multiple binding sites for I-125 RTI-121 and other cocaine analogs in rat frontal cerebral cortex
Publisher
An entity responsible for making the resource available
Synapse
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
Neurosciences & Neurology; localization; h-3 gbr-12935 binding; transporter; membranes; dopamine transporter; cocaine; nucleus-accumbens; norepinephrine transporter; medial prefrontal cortex; brain synaptosomes; glycosylation; human dopamine; reinforcing properties; RTI-121; self-stimulation; serotonin transporter; striatal
Creator
An entity primarily responsible for making the resource
Boja J W; Carroll F I; Vaughan R A; Kopajtic T; Kuhar M J
Description
An account of the resource
In an effort to identify novel binding sites for cocaine and its analogs, we carried out binding studies with the high-affinity and selective ligand [I-125]RTI-121 in rat frontal cortical tissue. Very low densities of binding sites were found. Saturation analysis revealed that the binding was to both high- and low-affinity sites. Pharmacological competition studies were carried out with inhibitors of the dopamine, norepinephrine, and serotonin transporters. The various transporter inhibitors inhibited the binding of 15 pM [I-125]RTI-121 in a biphasic fashion following a two-site binding model. The resultant data were complex and did not suggest a simple association with any single transporter. Correlational analysis supported the following hypothesis: [I-125] RTI-121 binds to known transporters and not to novel sites; these include dopamine, norepinephrine, and serotonin transporters. Immunoprecipitation of transporters photoaffinity labeled with [(125)] RTI-82 and subsequent analysis of SDS-page gels revealed the presence of authentic dopamine transporters in these samples; displacement of the photoaffinity label occurred with a typical dopamine transporter pharmacology. These data are compatible with the binding properties of RTI-181 and the presence of several known transporters in the tissue studied. Synapse 30:9-17, 1998. (C) 1998 Wiley-Liss, Inc.dagger
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p" target="_blank" rel="noreferrer noopener">10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Boja J W
brain synaptosomes
Carroll F I
Cocaine
Dopamine transporter
Glycosylation
h-3 gbr-12935 binding
human dopamine
Journal Article or Conference Abstract Publication
Kopajtic T
Kuhar M J
localization
medial prefrontal cortex
membranes
Neurosciences & Neurology
norepinephrine transporter
nucleus-accumbens
reinforcing properties
RTI-121
self-stimulation
serotonin transporter
striatal
synapse
transporter
Vaughan R A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1096-9861(19960304)366:2%3C244::aid-cne5%3E3.3.co;2-i" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1096-9861(19960304)366:2%3C244::aid-cne5%3E3.3.co;2-i</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
244-258
Issue
2
Volume
366
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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Title
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Regional distribution of cytochrome P450 2D1 in the rat central nervous system
Publisher
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Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
4-hydroxylation; catecholamine metabolism; debrisoquine sparteine-type; dopamine; drug-metabolism; h-3 gbr-12935 binding; human-brain; immunohistochemical localization; multiple forms; Neurosciences & Neurology; neurotoxin; parkinsons-disease; parkinsons-disease; polymorphism; striatal membranes; transporter; xenobiotics; Zoology
Creator
An entity primarily responsible for making the resource
Norris P J; Hardwick J P; Emson P C
Description
An account of the resource
Cytochrome P450s are enzymes involved in the oxidative metabolism of numerous endogenous and exogenous molecules. The enzyme cytochrome debrisoquine/sparteine-type monoxygenase is a specific form of cytochrome P450 and is found in the liver and the brain (in the rat the enzyme is known as CYP2D1). CYP2D1 has no established role in the brain; however, it has been shown to share substrate and inhibitor specificities with the dopamine transporter and the enzyme monoamine oxygenase B. Using CYP2D-specific deoxyoligonucleotide probes and a polyclonal antibody to CYP2D1, we have mapped the distribution of CYP2D mRNA and CYP2D1-like immunoreactivity in the rat central nervous system. CYP2D1 immunoreactivity and the CYP2D mRNA signal were heterogenously distributed between brain areas. There were moderate to high levels of immunoreactivity and mRNA signal in the olfactory bulb, olfactory tubercle, cerebral cortex, hippocampus, dentate gyrus, piriform cortex, caudate putamen, supraoptic nucleus, medial habenula, hypothalamus, thalamus, medial mamilliary nucleus and superior colliculus. In the brainstem, strong CYP2D1 immuno-reactivity and CYP2D mRNA signal were observed in the substantia nigra compacta, red nucleus, interpeduncular nucleus, pontine grey, locus coeruleus, cerebellum, and the ventral horn of the spinal cord. This study indicates that CYP2D1 is widely and constitutively expressed in neuronal and some glial populations in the rat brain. The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines. (C) 1996 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1096-9861(19960304)366:2%3C244::aid-cne5%3E3.3.co;2-i" target="_blank" rel="noreferrer noopener">10.1002/(sici)1096-9861(19960304)366:2%3C244::aid-cne5%3E3.3.co;2-i</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1996
4-hydroxylation
catecholamine metabolism
debrisoquine sparteine-type
Dopamine
drug-metabolism
Emson P C
h-3 gbr-12935 binding
Hardwick J P
human-brain
immunohistochemical localization
Journal Article
Journal of Comparative Neurology
multiple forms
Neurosciences & Neurology
neurotoxin
Norris P J
parkinsons-disease
Polymorphism
striatal membranes
transporter
xenobiotics
Zoology