1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00315994" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00315994</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
381-390
Issue
5
Volume
96
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aggregation Of Myonuclei And The Spread Of Slow-tonic Myosin Immunoreactivity In Developing Muscle-spindles
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
Cell Biology; expression; fibers; heavy-chain isoforms; innervation; motor; rat; skeletal-muscle
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
The pattern of regional expression of a slowtonic myosin heavy chain (MHC) isoform was studied in developing rat soleus intrafusal muscle fibers. Binding of the slow-tonic antibody (ATO) began at the equator of prenatal intrafusal fibers where sensory nerve endings are located, and spread into the polar regions of nuclear bag2 and bag1 fibers but not nuclear chain fibers during ontogeny. The onset of the ATO reactivity coincided with the appearance of equatorial clusters of myonuclei (nuclear bag formations) in bag1 and bag2 fibers. Moreover, the intensity of the ATO reaction was strongest in the region of equatorial myonuclei and decreased with increasing distance from the equator of bag1 and bag2 fibers at all stages of prenatal and postnatal development. The polar expansion of ATO reactivity continued throughout the postnatal development of bag1 fibers, but ceased shortly after birth in bag2 fiber coincident with innervation by motor axons. Thus, afferents that innervate the equator might induce the slow-tonic MHC isoform in bag2 and bag1 fibers by regulating the myosin gene expression by equatorial myonuclei, and efferents or twitch contractile activity might inhibit the spread of the slow-tonic MHC isoform into the poles of bag2 but not bag1 fibers. Absence of ATO binding in chain fibers suggests that chain myotubes may not be as susceptible to the effect of afferents as are myotubes that develop into bag2 and bag1 fibers. The different patterns of slow-tonic MHC expression in the three types of intrafusal fiber may therefore result from the interaction of three elements: sensory neurons, motor neurons, and intrafusal myotubes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00315994" target="_blank" rel="noreferrer noopener">10.1007/bf00315994</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Cell Biology
expression
fibers
heavy-chain isoforms
Histochemistry
innervation
Journal Article or Conference Abstract Publication
Kucera J
motor
rat
skeletal-muscle
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00266761" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00266761</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
51-57
Issue
1
Volume
96
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Slow-tonic Mhc Expression In Paralyzed Hindlimbs Of Fetal Rats
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
Cell Biology; heavy-chain isoforms; innervation; intrafusal muscle-fibers; numbers; spindles
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
Whether nerve activity and active contraction of myotubes are essential for the assembly and initial differentiation of muscle spindles was investigated by paralyzing fetal rats with tetrodotoxin (TTX) from embryonic day 16 (E16) to E21, prior to and during the period when spindles typically form. TTX-treated soleus muscles were examined by light and electron microscopy for the presence of spindles and expression of myosin heavy chain (MHC) isoforms by the intrafusal fibers. Treatment with TTX did not inhibit the formation of a spindle capsule or the expression of a slow-tonic MHC isoform characteristic of intrafusal fibers, but did retard development of spindles. Spindles of TTX-treated E21 muscles usually consisted of one intrafusal fiber (bag2) only rather than two fibers (bag1 and bag2) typically present in untreated (control) E21 spindles. Intrafusal fibers of TTX-treated spindles also had only one sensory region supplied by multiple afferents, and were devoid of motor innervation. These features are characteristic of spindles in normal E18-E19 muscles. Thus, nerve and/or muscle activity is not essential for the assembly of muscle spindles, formation of a spindle capsule, and transformation of undifferentiated myotubes into the intrafusal fibers containing spindle-specific myosin isoforms. However, activity may promote the maturation of intrafusal bundles, as well as the maturation of afferent and efferent nerve supplies to intrafusal fibers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00266761" target="_blank" rel="noreferrer noopener">10.1007/bf00266761</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Cell Biology
heavy-chain isoforms
Histochemistry
innervation
intrafusal muscle-fibers
Journal Article or Conference Abstract Publication
Kucera J
numbers
spindles
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00185898" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00185898</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
397-408
Issue
4
Volume
187
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential-effects Of Neonatal Denervation On Intrafusal Muscle-fibers In The Rat
Publisher
An entity responsible for making the resource available
Anatomy and Embryology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-04
Subject
The topic of the resource
afferents; Anatomy & Morphology; denervation; Developmental Biology; expression; heavy-chain isoforms; innervation; intrafusal muscle fiber; motor denervation; muscle spindles; myosin heavy chains; neonatal rat; nerve dependence; nerve growth-factor; spindle development; spindles
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M; Reichler J
Description
An account of the resource
The response of developing muscle spindles to denervation was studied by sectioning the nerve to the medial gastrocnemius muscle of rats at birth. The denervated spindles were examined daily throughout the first postnatal week for changes in ultrastructure and expression of several isoforms of myosin heavy chain (MHC). Each of the three different types of intrafusal muscle fiber exhibited a different response to denervation. Within 5 days after the nerve section nuclear bag, fibers degenerated completely; nuclear bag1 fibers persisted, but ceased to express the 'spindle-specific' slow-tonic MHC isoform and thereby could not be differentiated from extrafusal fibers; nuclear chain fibers did not form. The capsules of spindles disassembled, hence spindles or their remnants could no longer be identified 1 week after denervation. Neonatal deefferentation has little effect on these features of developing spindles, so removal of afferent innervation is presumably the factor that induces the loss of spindles in denervated muscles. Degeneration of the bag2 fiber, but not bag1 or extrafusal fibers, reflects a greater dependence of the bag2 fiber than the bag1 fiber on afferent innervation for maintenance of its structural integrity. This difference in response of the two types of immature bag fiber to denervation might reflect an origin of the bag2 fibers from a lineage of myogenic cells distinct from that giving rise to bag1 or extrafusal fibers, or a difference in the length of contact with afferents between the two types of bag fiber prior to nerve section.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00185898" target="_blank" rel="noreferrer noopener">10.1007/bf00185898</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
afferents
Anatomy & Morphology
Anatomy and embryology
Denervation
Developmental Biology
expression
heavy-chain isoforms
innervation
intrafusal muscle fiber
Journal Article or Conference Abstract Publication
Kucera J
motor denervation
muscle spindles
myosin heavy chains
neonatal rat
nerve dependence
nerve growth-factor
Reichler J
spindle development
spindles
Walro J M