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Text
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<a href="http://doi.org/10.1111/j.1471-4159.2006.04141.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1471-4159.2006.04141.x</a>
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Pages
1033-1048
Issue
4
Volume
99
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Title
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Multifunctional drugs with different CNS targets for neuropsychiatric disorders
Publisher
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Journal of Neurochemistry
Date
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2006
2006-11
Subject
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alzheimers-disease; alzheimers-disease; amyotrophic lateral sclerosis; Biochemistry & Molecular Biology; depressive illness; designed multiple ligands; hetero-cage compounds; iron chelator; Lewy body disease; monoamine oxidase inhibitor; mptp-induced neurotoxicity; neurodegenerative diseases; Neurosciences & Neurology; nicotinic acetylcholine-receptors; nonsteroidal antiinflammatory drugs; parkinsons-disease; parkinsons-disease; schizophrenia
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Van der Schyf C J; Geldenhuys W J; Youdim M B H
Description
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The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia, depressive illness and stroke, offer significant challenges to drug discovery efforts aimed at preventing or even reversing the progression of these disorders. Transcriptomic tools and proteomic profiling have clearly indicated that such diseases are multifactorial in origin. Further, they are thought to be initiated by a cascade of molecular events that involve several neurotransmitter systems. In response to this complexity, a new paradigm has recently emerged that challenges the widely held assumption that 'silver bullet' agents are superior to 'dirty drugs' in therapeutic approaches aimed at the prevention or treatment of neuropsychiatric diseases. A similar pattern of drug development has occurred in strategies for the treatment of cancer, AIDS and cardiovascular diseases. In this review, we offer an overview of therapeutic strategies and novel investigative drugs discovered or developed in our own and other laboratories, that address multiple CNS etiological targets associated with an array of neuropsychiatric disorders.
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<a href="http://doi.org/10.1111/j.1471-4159.2006.04141.x" target="_blank" rel="noreferrer noopener">10.1111/j.1471-4159.2006.04141.x</a>
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Journal Article
2006
alzheimers-disease
amyotrophic lateral sclerosis
Biochemistry & Molecular Biology
depressive illness
designed multiple ligands
Geldenhuys W J
hetero-cage compounds
iron chelator
Journal Article
Journal of neurochemistry
Lewy body disease
monoamine oxidase inhibitor
mptp-induced neurotoxicity
Neurodegenerative Diseases
Neurosciences & Neurology
nicotinic acetylcholine-receptors
nonsteroidal antiinflammatory drugs
parkinsons-disease
Schizophrenia
Van der Schyf C J
Youdim M B H