Mechanisms Of Metabolic Coronary Flow Regulation
Adenosine; arteriolar; Carbon dioxide; Cardiovascular System & Cardiology; Cell Biology; Coronary blood flow; dilation; guinea-pig heart; heterogeneity; hydrogen-peroxide; hypercapnic acidosis; Ion channels; k-atp channels; microvascular dilation; myocardial blood-flow; nitric-oxide; nitric-oxide; Oxygen; Prostaglandins; Reactive oxygen species; sensitive potassium channels; spatial
Deussen A; Ohanyan V; Jannasch A; Yin L Y; Chilian W
Journal of Molecular and Cellular Cardiology
2012
2012-04
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.yjmcc.2011.10.001" target="_blank" rel="noreferrer noopener">10.1016/j.yjmcc.2011.10.001</a>
Relapsed Perinatal Neuroblastoma After Expectant Observation
age; Hematology; heterogeneity; infants; neuro-blastoma; neuro-blastoma; neuroblastoma biology; Oncology; Pediatrics; regression; relapse
The Children's Oncology Group (COG) study ANBL00P2 showed that expectant observation of patients younger than six months of age with perinatal neuroblastoma presenting as a small adrenal mass yields excellent overall survival and spares surgical resection to the majority of patients. We report a 5-year-old female who was initially diagnosed with a perinatal neuroblastoma. The patient was observed on COG study ANBL00P2. By nine months of age she had no ultrasonographic or biochemical evidence of disease. She presented four years later with abdominal pain and was found to have high-risk stage 4 MYCN amplified neuroblastoma. Pediatr Blood Cancer 2015;62:160-162. (c) 2014 Wiley Periodicals, Inc.
Salloum R; Garrison A; von Allmen D; Sheridan R; Towbin A J; Adams D; Weiss B
Pediatric Blood & Cancer
2015
2015-01
Journal Article
<a href="http://doi.org/10.1002/pbc.25218" target="_blank" rel="noreferrer noopener">10.1002/pbc.25218</a>
SELECTIVE SUBREGIONAL DOPAMINE DEPLETIONS IN THE RAT CAUDATE-PUTAMEN FOLLOWING NIGROSTRIATAL LESIONS
heterogeneity; innervation; Neurosciences & Neurology; nucleus-accumbens; projection; striatum; substantia-nigra
Previous work has demonstrated a complex neurochemical and neuroanatomical heterogeneity of the striatum in normal brains. The present research investigated whether the heterogeneous distribution of dopamine would be altered following unilateral injections of the neurotoxin 6-hydroxydopamine into the substantia nigra of the rat. Four weeks following injection, the nucleus accumbens and subregions of the caudate-putamen and substantia nigra were dissected and analyzed by HPLC with electrochemical detection for dopamine, 5-hydroxytryptamine, and their respective metabolites. Levels of dopamine and its metabolites in the anterodorsolateral caudate-putamen were depleted more than medial, posterior, and ventral, striatal areas in partially lesioned animals (< 90% dopamine depletion). This resulted in an alteration of striatal heterogeneity such that a mediolateral gradient of dopamine tissue content was now superimposed on the normal rostrocaudal gradient observed in controls. Paralleling these findings, dopamine was more depleted in the lateral, as opposed to the medial, substantia nigra. These results indicate that the nigrostriatal dopamine system degenerates in a heterogeneous fashion following 6-hydroxydopamine administration. It is speculated that the differential loss of dopamine neurons observed in the nigra of Parkinson's patients may be due to a differential sensitivity to toxins within the nigra.
Pehek E A; Crock R; Yamamoto B K
Synapse
1992
1992-04
Journal Article
<a href="http://doi.org/10.1002/syn.890100406" target="_blank" rel="noreferrer noopener">10.1002/syn.890100406</a>