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Text
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URL Address
<a href="http://doi.org/10.1002/adem.201500282" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/adem.201500282</a>
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Pages
518-531
Issue
4
Volume
18
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Title
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A Novel Hybrid-Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S-epidermidis Biofilm Accumulation
Publisher
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Advanced Engineering Materials
Date
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2016
2016-04
Subject
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differentiation; energy; hydrophilicity; implants; in-vitro; Materials Science; nanotopography; osseointegration; osteoactivin; osteoblast lineage cells; responses
Creator
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Park B W; Krieger J; Sondag G R; Moussa F M; Rankenberg J; Safadi F F; Gatsonis N A; McGimpsey W G; Lambert C R; Malcuit C
Description
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We provide a comparative analysis of protein adsorption, primary human cell behavior, and biofilm formation on modified titanium substrates of either micro-, nano-, or hybrid micro/nano-scale feature sizes. While studies revealed that nano-scale structures initially decreased the attachment and spreading of both human fibroblasts (hDFs) and mesenchymal stem cells (hMSCs), hMSC differentiation studies revealed that hybrid structures promoted the highest levels of osteogenic gene expression and attenuated biofilm formation by Staphylococcus epidermidis. Taken together, this novel approach of generating a hybrid topographical feature results in a potential implant material capable of enhanced dermal cell adhesion and osteogenic differentiation while limiting biofilm accumulation.
Identifier
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<a href="http://doi.org/10.1002/adem.201500282" target="_blank" rel="noreferrer noopener">10.1002/adem.201500282</a>
Format
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Journal Article
2016
Advanced Engineering Materials
differentiation
energy
Gatsonis N A
hydrophilicity
Implants
in-vitro
Journal Article
Krieger J
Lambert C R
Malcuit C
Materials Science
McGimpsey W G
Moussa F M
nanotopography
osseointegration
OSTEOACTIVIN
osteoblast lineage cells
Park B W
Rankenberg J
responses
Safadi F F
Sondag G R