1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1097/00024382-199602000-00008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00024382-199602000-00008</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 130-134 Issue 2 Volume 5 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hypertonic Saline In Stabilized Hyperdynamic Sepsis Publisher An entity responsible for making the resource available Shock Date A point or period of time associated with an event in the lifecycle of the resource 1996 1996-02 Subject The topic of the resource & Cardiology; cardiac-output; Cardiovascular System; delivery; dogs; fluid resuscitation; General & Internal Medicine; Hematology; hyperosmotic nacl; osmolality; oxygen consumption; respiratory-distress syndrome; septic shock; severe hemorrhagic-shock; Surgery Creator An entity primarily responsible for making the resource Hannemann L; Reinhart K; Korell R; Spies C; Bredle D L Description An account of the resource Hypertonic saline with or without colloidal solution has been successfully used for treating hemorrhagic shock in animal experiments and clinical studies. Due to its various effects at systemic, organ, and microcirculatory levels, the substance appears to be a promising candidate for improving tissue oxygenation in sepsis. We therefore investigated the hypothesis that infusion of hypertonic saline would further improve O-2 delivery, O-2 extraction, and O-2 uptake in hyperdynamic septic shock patients already stabilized by adequate volume and catecholamine infusion. Twenty-one patients received 2-4 mL/kg body weight of hypertonic saline in hydroxyethyl starch within 15 min. This hypertonic saline infusion caused a rapid significant increase in O-2 delivery by 14% but only a marginal increase in O-2 consumption (7% by cardiovascular Fick [p < .05], 4% by respiratory gases [n.s.]). Hypertonic saline increased the already elevated cardiac output by 24%. The pulmonary capillary wedge pressure increased from 14 +/- 3 to 23 +/- 3 mmHg and pulmonary shunt fraction increased 15%, but arterial PO2 did not fall. Except for the increase in pulmonary capillary wedge pressure, none of the cardiovascular changes lasted longer than 60 min. Plasma sodium levels increased from 138 +/- 25 to 163 +/- 38 mmol/L and normalized within 24 h. In these hyperdynamic septic patients, hypertonic saline infusion produced a transient increase in circulation, but no evidence of a substantial increase in O-2 consumption. Either there was no significant O-2 debt due to the already elevated O-2 delivery levels at baseline (700 mL/min/m(2)) or the global O-2 measurements we used were not able to detect discrete regional hypoxia. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/00024382-199602000-00008" target="_blank" rel="noreferrer noopener">10.1097/00024382-199602000-00008</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication & Cardiology 1996 Bredle D L cardiac-output Cardiovascular System Delivery Dogs fluid resuscitation General & Internal Medicine Hannemann L Hematology hyperosmotic nacl Journal Article or Conference Abstract Publication Korell R osmolality Oxygen Consumption Reinhart K respiratory-distress syndrome Septic shock severe hemorrhagic-shock Shock Spies C Surgery