1 40 3 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.intimp.2020.106612</a> Pages 106612 Volume 85 ISSN 1878-1705 1567-5769 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.intimp.2020.106612</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number June 2020 Update II NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting Publisher An entity responsible for making the resource available International immunopharmacology Date A point or period of time associated with an event in the lifecycle of the resource 2020 2020-05-22 Subject The topic of the resource Imperatorin; inflammation; iNOS; Osteoarthritis; Oxidative-stress; Plant-derived-polyphenol Creator An entity primarily responsible for making the resource Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M Description An account of the resource Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways. We pretreated chondrocytes or explants with Imperatorin (50 muM) followed by Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">10.1016/j.intimp.2020.106612</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2020 Ahmad Nashrah Ansari Mohammad Y Bano Shabana Department of Anatomy & Neurobiology Haqqi Tariq M Imperatorin Inflammation iNOS International Immunopharmacology journalArticle June 2020 Update II NEOMED College of Medicine Osteoarthritis Oxidative-stress Plant-derived-polyphenol Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/jcp.29607" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.29607</a> Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1002/jcp.29607" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/jcp.29607</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number March 2020 Update NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Role of iNOS in osteoarthritis: Pathological and therapeutic aspects. Publisher An entity responsible for making the resource available Journal of cellular physiology Date A point or period of time associated with an event in the lifecycle of the resource 2020 2020-02 Subject The topic of the resource chondrocytes; osteoarthritis; iNOS; oxidative stress; inflammation; nitric oxide; iNOS inhibitor Creator An entity primarily responsible for making the resource Ahmad Nashrah; Ansari Mohammad Y; Haqqi Tariq M Description An account of the resource Accumulating evidence suggests that inflammation has a key role in the pathogenesis of osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory mediators in OA and drives many pathological changes during the development and progression of OA. Excessive production of NO in chondrocytes promotes cartilage destruction and cellular injury. The synthesis of NO in chondrocytes is catalyzed by inducible NO synthase (iNOS), which is thereby an attractive therapeutic target for the treatment of OA. A number of direct and indirect iNOS inhibitors, bioactive compounds, and plant-derived small molecules have been shown to exhibit chondroprotective effects by suppressing the expression of iNOS. Many of these iNOS inhibitors hold promise for the development of new, disease-modifying therapies for OA; however, attempts to demonstrate their success in clinical trials are not yet successful. Many plant extracts and plant-derived small molecules have also shown promise in animal models of OA, though further studies are needed in human clinical trials to confirm their therapeutic potential. In this review, we discuss the role of iNOS in OA pathology and the effects of various iNOS inhibitors in OA. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/jcp.29607" target="_blank" rel="noreferrer noopener">10.1002/jcp.29607</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource Journal Article 2020 Ahmad Nashrah Ansari Mohammad Y Chondrocytes Department of Anatomy & Neurobiology Haqqi Tariq M Inflammation iNOS iNOS inhibitor Journal of cellular physiology NEOMED College of Medicine NITRIC oxide Osteoarthritis Oxidative Stress Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.3389/fphar.2015.00292" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fphar.2015.00292</a> Pages 292–292 Volume 6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inducible Nitric Oxide Inhibitors Block NMDA Antagonist-Stimulated Motoric Behaviors and Medial Prefrontal Cortical Glutamate Efflux. Publisher An entity responsible for making the resource available Frontiers in pharmacology Date A point or period of time associated with an event in the lifecycle of the resource 2015 1905-07 Subject The topic of the resource schizophrenia; ataxia; green tea; iNOS; microdialysis; nNOS; phencyclidine; stereotypy Creator An entity primarily responsible for making the resource Bergstrom Hadley C; Darvesh Altaf S; Berger S P Description An account of the resource Nitric oxide (NO) plays a critical role in the motoric and glutamate releasing action of N-methyl-D-aspartate (NMDA)-antagonist stimulants. Earlier studies utilized neuronal nitric oxide synthase inhibitors (nNOS) for studying the neurobehavioral effects of non-competitive NMDA-antagonist stimulants such as dizocilpine (MK-801) and phencyclidine (PCP). This study explores the role of the inducible nitric oxide synthase inhibitors (iNOS) aminoguanidine (AG) and (-)-epigallocatechin-3-gallate (EGCG) in NMDA-antagonist induced motoric behavior and prefrontal cortical glutamate e ffl ux. Adult male rats were administered a dose range of AG, EGCG, or vehicle prior to receiving NMDA antagonists MK-801, PCP, or a conventional psychostimulant (cocaine) and tested for motoric behavior in an open arena. Glutamate in the medial prefrontal cortex (mPFC) was measured using in vivo microdialysis after a combination of AG or EGCG prior to MK-801. Acute administration of AG or EGCG dose-dependently attenuated the locomotor and ataxic properties of MK-801 and PCP. Both AG and EGCG were unable to block the motoric effects of cocaine, indicating the acute pharmacologic action of AG and EGCG is specific to NMDA antagonism and not generalizable to all stimulant class drugs. AG and EGCG normalized MK-801-stimulated mPFC glutamate e ffl ux. These data demonstrate that AG and EGCG attenuates NMDA antagonist-stimulated motoric behavior and cortical glutamate e ffl ux. Our results suggest that EGCG-like polyphenol nutraceuticals (contained in "green tea" and chocolate) may be clinically useful in protecting against the adverse behavioral dissociative and cortical glutamate stimulating effects of NMDA antagonists. Medications that interfere with NMDA antagonists such as MK-801 and PCP have been proposed as treatments for schizophrenia. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.3389/fphar.2015.00292" target="_blank" rel="noreferrer noopener">10.3389/fphar.2015.00292</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2015 ataxia Berger S P Bergstrom Hadley C Darvesh Altaf S Department of Pharmaceutical Sciences Frontiers in pharmacology green tea iNOS Microdialysis NEOMED College of Pharmacy nNOS Phencyclidine Schizophrenia stereotypy