GEOGRAPHIC-DISTRIBUTION OF RHEUMATOID-ARTHRITIS IN ANCIENT NORTH-AMERICA - IMPLICATIONS FOR PATHOGENESIS
american indians; antiquity; defleshed bones; erosive arthritis; indians; new-world; paleopathology; rheumatoid-arthritis; Rheumatology; spondyloarthropathy
Rothschild B M; Woods R J; Rothschild C; Sebes J I
Seminars in Arthritis and Rheumatism
1992
1992-12
Journal Article
<a href="http://doi.org/10.1016/0049-0172(92)90018-9" target="_blank" rel="noreferrer noopener">10.1016/0049-0172(92)90018-9</a>
TREPONEMAL DISEASE REVISITED - SKELETAL DISCRIMINATORS FOR YAWS, BEJEL, AND VENEREAL SYPHILIS
defleshed bones; erosive arthritis; Immunology; indians; Infectious Diseases; Microbiology; origin; polymerase chain-reaction; rheumatoid-arthritis; spondyloarthropathy; world
Assigning responsibility for the origins of treponemal disease has been complicated because of the (diagnostic) impreciseness of the historical written record and the inability to microbiologically distinguish among the treponematoses. Bedouin skeletal remains of individuals from the Negev area of Israel who had bejel, skeletons from the Todd human skeleton collection of individuals in whom syphilis was diagnosed, and skeletal remains from Guam of individuals who had yaws were analyzed to quantitatively assess their skeletal damage, The osseous reactions, although reproducible for each variety of treponemal disease, are not uniform among these skeletons. Examination of population frequency, demographics, character, and skeletal distribution of osseous treponemal damage in these skeletal sites provides clear, reproducible clues to the identity of the underlying treponematosis: bejel and yaws are common (>20% according to skeletal findings) in the population. Syphilis and bejel usually spare the hands and feet. Yaws tends to be more polyostotic. Analysis of these parameters as population phenomena in pre-Columbian archeological sites should afford the opportunity to define the origins of the various treponemal disorders.
Rothschild B M; Rothschild C
Clinical Infectious Diseases
1995
1995-05
Journal Article
<a href="http://doi.org/10.1093/clinids/20.5.1402" target="_blank" rel="noreferrer noopener">10.1093/clinids/20.5.1402</a>
CALCIUM PYROPHOSPHATE DEPOSITION DISEASE - DESCRIPTION IN DEFLESHED SKELETONS
arthritis; bones; calcium pyrophosphate; chondrocalcinosis articularis; deposition disease; destructive arthropathy; disease; erosive arthritis; indians; paleopathology; Pathology; pseudogout; rheumatoid-arthritis; Rheumatology
The osseous appearance, skeletal distribution, and distinguishing features of calcium pyrophosphate deposition disease (CPPD) were delineated in a population of 2906 contemporary defleshed skeletons. The limitations of routine x-ray and clinical examination were transcended in this study of defleshed bones. The nature of the disease was clearly identified and preconceived notions (based on the ''shades of black and white'' of the conventional x-rav technique) were examined on the basis of the actual osseous impact. Epidemiologic assessment of this disease allowed it to be distinguished from rheumatoid and other erosive forms of arthritis. Analysis of the ''pseudo-rheumatoid'' subgroup of CPPD provided clear criteria for distinguishing the disease from rheumatoid arthritis. Characterization of the nature and epidemiology of osseous alterations in a contemporary skeletal population permitted the development of a standard for recognition of CPPD in skeletal populations and for clarification of the nature of associated pseudo-erosions.
Rothschild B M; Woods R J; Rothschild C
Clinical and Experimental Rheumatology
1992
1992-11
Journal Article
n/a
CHARACTER OF PRE-COLUMBIAN NORTH-AMERICAN SPONDYLOARTHROPATHY
ankylosing spondylitis; defleshed bones; enthesopathy; erosive arthritis; indians; joint fusion; new-world; paleopathology; polyarthritis; population; psoriatic-arthritis; reactive arthritis; rheumatoid-arthritis; Rheumatology; spondyloarthropathy
Shared characteristics and concurrent occurrence of rheumatoid arthritis (RA) and spondyloarthropathy in contemporary populations have compromised development of clear diagnostic criteria for distinguishing them. Although modern populations contain individuals with both RA and spondyloarthropathy, ancient populations often manifest only one. The presence of spondyloarthropathy as the sole erosive disease in selected ancient populations allows further clarification of its nature. The tendency towards pauciarticular, asymmetrical involvement, axial involvement and peripheral joint fusion in these populations clarifies diagnosis and distinguishes this phenomenon from RA. The significance of peripheral joint fusion appears to be unequivocally established on the basis of these findings.
Rothschild B M; Woods R J
Journal of Rheumatology
1992
1992-08
Journal Article
n/a
PALEOPATHOLOGY, ITS CHARACTER AND CONTRIBUTION TO UNDERSTANDING AND DISTINGUISHING AMONG RHEUMATOLOGIC DISEASES - PERSPECTIVES ON RHEUMATOID-ARTHRITIS AND SPONDYLOARTHROPATHY
ankylosis; defleshed bones; erosive arthritis; indians; new-world; nonhuman primates; paleopathology; polyarthritis; rheumatoid-arthritis; Rheumatology; spondyloarthropathy
Rothschild B M
Clinical and Experimental Rheumatology
1995
1995-09
Journal Article
n/a