1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2217/bmm.13.150" target="_blank" rel="noreferrer noopener">http://doi.org/10.2217/bmm.13.150</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
147-159
Issue
2
Volume
8
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Targeted Liquid Chromatography-mass Spectrometry Analysis Of Serum Acylcarnitines In Acetaminophen Toxicity In Children
Publisher
An entity responsible for making the resource available
Biomarkers in Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-02
Subject
The topic of the resource
-oxidation; acetaminophen; acute liver-failure; acylcarnitine; biomarker; clinical; clofibrate; hepatic; hepatotoxicity; induced; induced hepatic-necrosis; metabolism; metabolomics; mice; multicenter; overdose; protein adducts; Research & Experimental Medicine; toxicity
Creator
An entity primarily responsible for making the resource
Bhattacharyya S; Yan K; Pence L; Simpson P M; Gill P; Letzig L G; Beger R D; Sullivan J E; Kearns G L; Reed M D; Marshall J D; Van Den Anker J N; James L P
Description
An account of the resource
Aim: Long-chain acylcarnitines have been postulated to be sensitive biomarkers of acetaminophen (APAP)-induced hepatotoxicity in mouse models. In the following study, the relationship of acylcarnitines with other known indicators of APAP toxicity was examined in children receiving low-dose (therapeutic) and high-dose (overdose' or toxic ingestion) exposure to APAP. Materials & methods: The study included three subject groups: group A (therapeutic dose, n = 187); group B (healthy controls, n = 23); and group C (overdose, n = 62). Demographic, clinical and laboratory data were collected for each subject. Serum samples were used for measurement of APAP protein adducts, a biomarker of the oxidative metabolism of APAP and for targeted metabolomics analysis of serum acylcarnitines using ultra performance liquid chromatography-triple-quadrupole mass spectrometry. Results: Significant increases in oleoyl- and palmitoyl-carnitines were observed with APAP exposure (low dose and overdose) compared with controls. Significant increases in serum ALT, APAP protein adducts and acylcarnitines were observed in overdose children that received delayed treatment (time to treatment from overdose >24 h) with the antidote N-acetylcysteine. Time to peak APAP protein adducts in serum was shorter than that of the acylcarnitines and serum ALT. Conclusion: Perturbations in long-chain acylcarnitines in children with APAP toxicity suggest that mitochrondrial injury and associated impairment in the -oxidation of fatty acids are clinically relevant as biomarkers of APAP toxicity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2217/bmm.13.150" target="_blank" rel="noreferrer noopener">10.2217/bmm.13.150</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
-oxidation
2014
ACETAMINOPHEN
acute liver-failure
acylcarnitine
Beger R D
Bhattacharyya S
Biomarker
Biomarkers in Medicine
Clinical
Clofibrate
Gill P
hepatic
hepatotoxicity
Induced
induced hepatic-necrosis
James L P
Journal Article or Conference Abstract Publication
Kearns G L
Letzig L G
Marshall J D
Metabolism
Metabolomics
Mice
multicenter
Overdose
Pence L
protein adducts
Reed M D
Research & Experimental Medicine
Simpson P M
Sullivan J E
toxicity
Van Den Anker J N
Yan K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2217/bmm.13.150" target="_blank" rel="noreferrer noopener">http://doi.org/10.2217/bmm.13.150</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
147-159
Issue
2
Volume
8
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Targeted Liquid Chromatography-mass Spectrometry Analysis Of Serum Acylcarnitines In Acetaminophen Toxicity In Children
Publisher
An entity responsible for making the resource available
Biomarkers in Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-02
Subject
The topic of the resource
-oxidation; acetaminophen; acute liver-failure; acylcarnitine; biomarker; clinical; clofibrate; hepatic; hepatotoxicity; induced; induced hepatic-necrosis; metabolism; metabolomics; mice; multicenter; overdose; protein adducts; Research & Experimental Medicine; toxicity
Creator
An entity primarily responsible for making the resource
Bhattacharyya S; Yan K; Pence L; Simpson P M; Gill P; Letzig L G; Beger R D; Sullivan J E; Kearns G L; Reed M D; Marshall J D; Van Den Anker J N; James L P
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2217/bmm.13.150" target="_blank" rel="noreferrer noopener">10.2217/bmm.13.150</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
-oxidation
2014
ACETAMINOPHEN
acute liver-failure
acylcarnitine
Beger R D
Bhattacharyya S
Biomarker
Biomarkers in Medicine
Clinical
Clofibrate
Gill P
hepatic
hepatotoxicity
Induced
induced hepatic-necrosis
James L P
Kearns G L
Letzig L G
Marshall J D
Metabolism
Metabolomics
Mice
multicenter
Overdose
Pence L
protein adducts
Reed M D
Research & Experimental Medicine
Simpson P M
Sullivan J E
toxicity
Van Den Anker J N
Yan K