Duration And Cessation Of Antimicrobial Treatment
acinetobacter-baumannii; antibiotic-therapy; antimicrobial resistance; case studies; catheter-related bloodstream; clinical-practice guidelines; clinical-practice guidelines; community-acquired pneumonia; complicated intra-abdominal; course; General & Internal Medicine; healthcare-associated pneumonia; hospital-acquired pneumonia; infection; infectious-diseases-society; intensive-care units; pseudomonas-aeruginosa; resistant; short-course therapy; staphylococcus-aureus bacteremia; streptococcus-pneumoniae; ventilator-acquired pneumonia; ventilator-associated pneumonia
File T M
Journal of Hospital Medicine
2012
2012-01
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/jhm.988" target="_blank" rel="noreferrer noopener">10.1002/jhm.988</a>
Serum procalcitonin in the diagnosis and management of intra-abdominal infections
acute; anti-thymocyte globulin; antibiotic-therapy; antibiotic-therapy; appendicitis; c-reactive protein; critically-ill patients; intensive-care units; international multicenter; liver-transplantation; liver-transplantation; major abdominal-surgery; pancreatitis; peritonitis; Pharmacology & Pharmacy; procalcitonin; sepsis; spontaneous bacterial
The biomarker procalcitonin (PCT) has been used to diagnose and monitor a number of clinically significant infections. Serum levels of PCT are often increased in the presence of bacterial and fungal infections but not viral infections or noninfectious inflammation. Intra-abdominal infections (IAIs) are serious conditions that pose difficult challenges to physicians and the healthcare system. Researchers have evaluated PCT in the management of IAIs, both for diagnosis and for guiding antibiotic therapy. The studies have produced mixed results, leading to controversy on the utility of PCT in IAIs. PCT appears to be most useful in diagnosing postoperative infections and necrotizing pancreatitis. This review aims to summarize these data, explore the pathophysiology of PCT in sepsis from IAIs, discuss the strengths and weaknesses of PCT monitoring in IAIs, and provide guidance for the interpretation of PCT levels.
Watkins R R; Lemonovich T L
Expert Review of Anti-Infective Therapy
2012
2012-02
Journal Article
<a href="http://doi.org/10.1586/eri.11.164" target="_blank" rel="noreferrer noopener">10.1586/eri.11.164</a>