1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/40.2.1552171" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/40.2.1552171</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
293-307
Issue
2
Volume
40
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Expression Of Type-specific Mhc Isoforms In Rat Intrafusal Muscle-fibers
Publisher
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Journal of Histochemistry & Cytochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
cat; Cell Biology; differentiation; fiber types; histochemistry; identification; immunocytochemistry; innervation; intrafusal; monoclonal antimyosin antibodies; monoclonal-antibody; motor; muscle fiber typing; muscle spindles; myosin heavy-chain; rat skeletal muscle; skeletal-muscle; spindles
Creator
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Kucera J; Walro J M; Gorza L
Description
An account of the resource
Myosin heavy chain (MHC) expression by intrafusal fibers was studied by immunocytochemistry to determine how closely it parallels MHC expression by extrafusal fibers in the soleus and tibialis anterior muscles of the rat. Among the MHC isoforms expressed in extrafusal fibers, only the slow-twitch MHC of Type 1 extrafusal fibers was expressed along much of the fibers. Monoclonal antibodies (MAb) specific for this MHC bound to the entire length of bag2 fibers and the extracapsular region of bag1 fibers. The fast-twitch MHC isoform strongly expressed by bag2 and chain fibers had an epitope not recognized by MAb to the MHC isoforms characteristic of developing muscle fibers or the three subtypes (2A, 2B, 2X) of Type 2 extrafusal fibers. Therefore, intrafusal fibers may express a fast-twitch MHC that is not expressed by extrafusal fibers. Unlike extrafusal fibers, all three intrafusal fiber types bound MAb generated against mammalian heart and chicken limb muscles. The similarity of the fast-twitch MHC of bag2 and chain fibers and the slow-tonic MHC of bag1 and bag2 fibers to the MHC isoforms expressed in avian extrafusal fibers suggests that phylogenetically primitive MHCs might persist in intrafusal fibers. Data are discussed relative to the origin and regional regulation of MHC isoforms in intrafusal and extrafusal fibers of rat hindlimb muscles.
Identifier
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<a href="http://doi.org/10.1177/40.2.1552171" target="_blank" rel="noreferrer noopener">10.1177/40.2.1552171</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
cat
Cell Biology
differentiation
fiber types
Gorza L
Histochemistry
identification
immunocytochemistry
innervation
intrafusal
Journal Article or Conference Abstract Publication
Journal of Histochemistry & Cytochemistry
Kucera J
monoclonal antimyosin antibodies
monoclonal-antibody
motor
muscle fiber typing
muscle spindles
myosin heavy-chain
rat skeletal muscle
skeletal-muscle
spindles
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(92)90052-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(92)90052-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
216-218
Issue
2
Volume
136
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Axotomy Induces Fusimotor-free Muscle-spindles In Neonatal Rats
Publisher
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Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-03
Subject
The topic of the resource
fibers; fusimotor system; intrafusal; intrafusal muscle fiber; nerve; Neurosciences & Neurology; spindle development
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J
Description
An account of the resource
Crushing the nerve to the medial gastrocnemius (MG) muscle at birth and administering nerve growth factor to rats afterwards results in a reinnervated muscle with supernumerary muscle spindles, some of which must have formed de novo. Structure and innervation of spindles in the reinnervated MG muscles were studied in serial 1-mu-m transverse sections. Two types of spindle-like encapsulations were observed. The prevalent type consisted of one to three small diameter intrafusal fibers with features of nuclear chain fibers or infrequently a nuclear bag fiber. The second type of encapsulation consisted of the small-diameter fibers located in a compartment which abutted a compartment containing a large diameter extrafusal fiber. All intrafusal fibers in spindles of the experimental muscles were innervated by afferents, but most of them (85%) were devoid of efferent innervation. Thus, immature fusimotor neurons may be more susceptible than spindle afferents to cell death after axotomy at birth.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(92)90052-9" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(92)90052-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
fibers
fusimotor system
intrafusal
intrafusal muscle fiber
Journal Article or Conference Abstract Publication
Kucera J
nerve
Neuroscience letters
Neurosciences & Neurology
spindle development
Walro J