1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00185950" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00185950</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
409-418
Issue
4
Volume
188
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transient Expression Of A Slow-tonic Mhc Isoform By Extrafusal Fibers In The Developing Rat
Publisher
An entity responsible for making the resource available
Anatomy and Embryology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-10
Subject
The topic of the resource
Anatomy & Morphology; denervation; Developmental Biology; diversity; extrafusal fibers; intrafusal fibers; intrafusal muscle-fibers; monoclonal-antibody; motor innervation; muscle; myosin heavy-chain; neonatal rats; skeletal-muscle; slow-tonic myosin; spindles
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
ALD 19, a monoclonal antibody that recognizes the slow-tonic myosin heavy chain (MHC) isoform, has been used extensively as a marker for nuclear bag intrafusal fibers of muscle spindles in developing and adult rats. Extrafusal fibers of adult rat hindlimb muscles do not express slow-tonic MHC. However, while using ALD 19 to trace the fate of intrafusal fibers following neonatal denervation, we noted that some extrafusal fibers of neonates also bound this antibody. The immunolabeled extrafusal fibers were a subset of slow fibers located in the deep axial regions of crural muscles. The same fiber subset transiently displayed a weak affinity for ALD 19 during the first postnatal week in normal muscles. Denervation at birth increased the intensity of ALD 19 immunolabelling by these extrafusal fibers and extended the duration of the slow-tonic immunoreactivity into the 2nd postnatal week, after which expression diminished or ceased. Demonstration that some developing extrafusal fibers have a nerve-independent capacity for transiently expressing slow-tonic MHC, an MHC previously thought to be expressed only by intrafusal fibers, raises the possibility that both types of fiber originate from a subset of bipotential slow primary myotubes in rat hindlimbs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00185950" target="_blank" rel="noreferrer noopener">10.1007/bf00185950</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
Anatomy & Morphology
Anatomy and embryology
Denervation
Developmental Biology
diversity
extrafusal fibers
intrafusal fibers
intrafusal muscle-fibers
Journal Article or Conference Abstract Publication
Kucera J
monoclonal-antibody
motor innervation
Muscle
myosin heavy-chain
neonatal rats
skeletal-muscle
slow-tonic myosin
spindles
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00234305" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00234305</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
273-286
Issue
3
Volume
190
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sequences Of Intrafusal Fiber Formation Are Muscle-dependent In Rat Hindlimbs
Publisher
An entity responsible for making the resource available
Anatomy and Embryology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-09
Subject
The topic of the resource
Anatomy & Morphology; cat; development; Developmental Biology; embryonic-development; expression; innervation; intrafusal fibers; motor; muscle; muscle spindles; myosin heavy chains; myosin heavy-chain; neonatal rats; skeletal-muscle; slow myosin; spindles; tenuissimus muscles
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
A rat muscle spindle typically contains four intrafusal fibers - one nuclear bag(2), one nuclear bag, and two nuclear chain fibers. We compared the sequence of formation of the three intrafusal fiber types among the tibialis anterior (TA), soleus (SOL) and medial gastrocnemius (RIG) muscles using immunocytochemistry of spindle-specific myosin heavy chain isoforms. Spindles of the TA began to differentiate earlier and acquired the full complement of intrafusal fibers sooner than spindles of the SOL or MG muscles. At the onset of spindle assembly, the intrafusal myotubes expressed myosin heavy chains similar to those expressed by extrafusal myotubes. The first intrafusal myotube then differentiated into the bag, fiber regardless of the muscle. However, the fate of the second-forming intrafusal myotube varied among the muscles studied. It usually differentiated into a chain fiber in the TA, into a bag(1) fiber in the SOL, and into either a bag(1) or a chain in the MG. The fate of the third-forminge was reciprocal to that of the second; i.e. in those spindles in which the bag(1) fiber was second to form, a chain was third, and vice versa. The fourth and last intrafusal myotube gave rise to a chain fiber. The inter- and intramuscular variability in the fate of intrafusal myotubes of the second and third generation argues against the existence of a program intrinsic to the myotubes that would mandate their differentiation along specific paths. Rather, an extrinsic regulatory factor, probably associated with the primary afferent neuron, may govern differentiation of pluripotential myotubes into particular types of intrafusal fiber. The fate of the intrafusal myotubes might then depend on the timing of the regulatory effect of afferents relative to the stage of development of the intrafusal bundle.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00234305" target="_blank" rel="noreferrer noopener">10.1007/bf00234305</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Anatomy & Morphology
Anatomy and embryology
cat
development
Developmental Biology
embryonic-development
expression
innervation
intrafusal fibers
Journal Article or Conference Abstract Publication
Kucera J
motor
Muscle
muscle spindles
myosin heavy chains
myosin heavy-chain
neonatal rats
skeletal-muscle
slow myosin
spindles
tenuissimus muscles
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00186003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00186003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
149-158
Issue
2
Volume
192
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Origin Of Intrafusal Fibers From A Subset Of Primary Myotubes In The Rat
Publisher
An entity responsible for making the resource available
Anatomy and Embryology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-08
Subject
The topic of the resource
afferents; Anatomy & Morphology; development; Developmental Biology; developmental myosins; expression; intrafusal fibers; isoforms; muscle; muscle spindles; muscle spindles; myosin heavy chains; myosin heavy-chain
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
S46, a monoclonal antibody (mAb) specific for the SM-1 and SM-2 isoforms of avian slow myosin heavy chains (MHC), was used to study the earliest stages of development of intrafusal fibers in muscle spindles of the rat hindlimb. Spindles formed only in the regions of fetal muscles that contained primary myotubes reactive to mAb S46, such as the axial region of the tibialis anterior muscle. The first intrafusal fiber to form, the nuclear bag, fiber, originated from within the population of S46-reactive primary myotubes. Binding of mAb S46 by myotubes giving rise to the bag, fibers preceded the appearance of encapsulated spindles in the muscles by electron microscopy. However, reactivity to S46 intensified in the myotubes transforming into bag, fibers after the innervation of the fibers by afferents, and dissipated in myotubes differentiating into slow-twitch (type I) extrafusal fibers. Thus, afferents may enhance intrafusal expression of the MHC isoform reactive to mAb S46. The pattern of S46 binding to nuclear bag and chain intrafusal fibers in both developing and adult spindles was the same as that reported for the mAb ALD19, suggesting that both antibodies bind to the same MHC isoform. This isoform is probably a developmental form of slow myosin, because it was transiently expressed during the development of type I extrafusal fibers. The origin of bag, intrafusal and type I extrafusal fibers from a bipotential subpopulation of primary myotubes reactive to mAb S46 correlates with the location of muscle spindles in the slow regions of muscles in adult rat hindlimbs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00186003" target="_blank" rel="noreferrer noopener">10.1007/bf00186003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
afferents
Anatomy & Morphology
Anatomy and embryology
development
Developmental Biology
developmental myosins
expression
intrafusal fibers
isoforms
Journal Article or Conference Abstract Publication
Kucera J
Muscle
muscle spindles
myosin heavy chains
myosin heavy-chain
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/aja.1001900107" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/aja.1001900107</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
74-88
Issue
1
Volume
190
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neural Organization Of Spindles In 3 Hindlimb Muscles Of The Rat
Publisher
An entity responsible for making the resource available
American Journal of Anatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Anatomy & Morphology; cat tenuissimus muscle; expression; fusimotor innervation; intrafusal fibers; lumbrical muscles; motor innervation; muscle; nuclear chain fibers; skeletofusimotor; soleus; ultrastructure
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M; Reichler J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/aja.1001900107" target="_blank" rel="noreferrer noopener">10.1002/aja.1001900107</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
American Journal of Anatomy
Anatomy & Morphology
cat tenuissimus muscle
expression
fusimotor innervation
intrafusal fibers
Journal Article or Conference Abstract Publication
Kucera J
lumbrical muscles
motor innervation
Muscle
nuclear chain fibers
Reichler J
skeletofusimotor
soleus
ultrastructure
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
173-190
Issue
3
Volume
41
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MORPHOMETRIC ANALYSIS OF COATED VESICLES IN DEVELOPING RAT MUSCLE-SPINDLES
Publisher
An entity responsible for making the resource available
Physiological Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992
Subject
The topic of the resource
acetylcholine-receptors; cells; coated vesicles; development; innervation; intrafusal fibers; membrane; morphometry; motor; muscle spindle; Physiology; rat
Creator
An entity primarily responsible for making the resource
Stephens H; Walro J M; Kucera J
Description
An account of the resource
The incidence of coated vesicles under sarcolemmal surfaces of equatorial, juxtaequatorial and polar regions in developing and adult spindles of the rat soleus muscle was examined by quantitative morphometry of transverse ultrathin sections. Coated vesicles were more numerous: 1) under primary sensory endings than under other types of neuromuscular contacts; 2) under the appositional sarcolemma between neighbouring intrafusal fibres than under free surfaces of the sarcolemma; and 3) in developing than in mature spindles. Factors such as location and age of the animal often interacted to produce an additive effect on the incidence of coated vesicles. Although there was a high incidence of coated vesicles at the postsynaptic surface under sensory terminals of bag2 fibres in 18 and 19 day gestational embryonic rats, it peaked in 4 day postnatal animals. The high incidence of coated vesicles at sensory endings supports the view that coated vesicles mediate neurotrophic interactions between afferents and intrafusal fibres during the critical late gestation and early postnatal time period, as sensory axons first contact their target fibres and exert a maximal directing influence on the differentiation of intrafusal fibre types. In addition, the preferential localization of coated vesicles under appositional rather than free surfaces of developing intrafusal fibres in 0-4 day rats suggests that they play a role in the transport of active substances among intrafusal fibres exhibiting different stages of maturity.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1992
acetylcholine-receptors
Cells
coated vesicles
development
innervation
intrafusal fibers
Journal Article
Kucera J
membrane
morphometry
motor
muscle spindle
Physiological Research
Physiology
rat
Stephens H
Walro J M