1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0022379" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0022379</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
10-10
Issue
7
Volume
6
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Overexpression of the Lung Cancer-Prognostic miR-146b MicroRNAs Has a Minimal and Negative Effect on the Malignant Phenotype of A549 Lung Cancer Cells
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-07
Subject
The topic of the resource
breast-cancer; diseases; expression profiles; glioma; inhibition; invasion; migration; Science & Technology - Other Topics; strand selection; target; tumors
Creator
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Patnaik S K; Kannisto E; Mallick R; Yendamuri S
Description
An account of the resource
Introduction: Expression levels of miR-146b-5p and -3p microRNAs in human non-small cell lung cancer (NSCLC) are associated with recurrence of the disease after surgery. To understand this, the effect of miR-146b overexpression was studied in A549 human lung cancer cells. Methods: A549 cells, engineered with lentiviruses to overexpress the human pre-miR-146b precursor microRNA, were examined for proliferation, colony formation on plastic surface and in soft agar, migration and invasiveness in cell culture and in vivo in mice, chemosensitivity to cisplatin and doxorubicin, and global gene expression. miR-146b expressions were assessed in microdissected stroma and epithelia of human NSCLC tumors. Association of miR-146b-5p and -3p expression in early stage NSCLC with recurrence was analyzed. Principal Findings: A549 pre-miR-146b-overexpressors had 3-8-fold higher levels of both miR-146b microRNAs than control cells. Overexpression did not alter cellular proliferation, chemosensitivity, migration, or invasiveness; affected only 0.3% of the mRNA transcriptome; and, reduced the ability to form colonies in vitro by 25%. In human NSCLC tumors, expression of both miR-146b microRNAs was 7-10-fold higher in stroma than in cancerous epithelia, and higher miR-146b-5p but lower 3p levels were predictive of recurrence. Conclusions: Only a minimal effect of pre-miR-146b overexpression on the malignant phenotype was seen in A549 cells. This could be because of opposing effects of miR-146b-5p and -3p overexpression as suggested by the conflicting recurrence-predictive values of the two microRNAs, or because miR-146b expression changes in non-cancerous stroma and not cancerous epithelia of tumors are responsible for the prognostic value of miR-146b.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0022379" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0022379</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2011
breast-cancer
DISEASES
expression profiles
Glioma
inhibition
invasion
Journal Article
Kannisto E
Mallick R
migration
Patnaik S K
PloS one
Science & Technology - Other Topics
strand selection
target
tumors
Yendamuri S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
692-697
Issue
8
Volume
61
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Suppression Of Pulmonary Metastases Of Rat Mammary-cancer By Recombinant Urokinase Plasminogen-activator Inhibitor
Publisher
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American Surgeon
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-08
Subject
The topic of the resource
adenocarcinomas; breast; cells; colon; extracellular-matrix degradation; invasion; membrane; model; monocytes; receptor-bound urokinase; Surgery
Creator
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Evans D M; Lin P L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
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Journal Article or Conference Abstract Publication
1995
adenocarcinomas
American Surgeon
breast
Cells
colon
Department of Family & Community Medicine
Evans D M
extracellular-matrix degradation
invasion
Lin P L
membrane
model
monocytes
NEOMED College of Medicine
receptor-bound urokinase
Surgery