Zhong D S; Kotian P; Wyrick C D; Seltzman H H; Kepler J A; Boja J W; Kuhar M J; Carroll F I
Publisher
Journal of Labelled Compounds & Radiopharmaceuticals
Date
1999
1999-03
Description
A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carboxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier-free sodium iodide-125 as the isotope source. Purification by reversed-phase HPLC gives [I-125]RTI-229 in good yield (89.4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/mu mol, 78.6 GBq/mu mol, based on the specific activity of the (NaI)-I-125 used).