1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1021/acs.jmedchem.1c00656">http://doi.org/10.1021/acs.jmedchem.1c00656</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus.
Creator
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Wang Z; Li J; Benin BM;Yu B; Bunge Scott D; Abeydeera N; Huang SD; Kim M-H
Publisher
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Journal Of Medicinal Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-06-17
Description
An account of the resource
Antibiotic resistance (AR) necessitates the discovery of new antimicrobials with alternative mechanisms of action to those employed by conventional antibiotics. One such strategy utilizes Ga3+ to target iron metabolism, a critical process for survival. Still, Ga-based therapies are generally ineffective against Gram-positive bacteria and promote Ga resistance. In response to these drawbacks, we report a lipophilic Ga complex, [Ga2L3(bpy)2] (L = 2,2′-bis(3-hydroxy-1,4-naphthoquinone; bpy = 2,2′-bipyridine)), effective against drug-resistant Pseudomonas aeruginosa (DRPA; minimum inhibitory concentration, MIC = 10 μM = 14.8 μg/mL) and methicillin-resistant Staphylococcus aureus (MRSA, MIC = 100 μM = 148 μg/mL) without iron-limited conditions. Importantly, [Ga2L3(bpy)2] shows noticeably delayed and decreased resistance in both MRSA and DRPA, with only 8× MIC in DRPA and none in MRSA after 30 passages. This is likely due to the dual mode of action afforded by Ga (disruption of iron metabolism) and the ligand (reactive oxygen species production). Overall, [Ga2L3(bpy)2] demonstrates the utility of lipophilic metal complexes with multiple modes of action in combatting AR in Gram-positive and Gram-negative bacteria.
Subject
The topic of the resource
In recent years, drug-resistant pathogenic bacteria have spread faster than the discovery of new antibiotics. (1,2) It is estimated that more than 30% of clinical isolates of Pseudomonas aeruginosa (P. aeruginosa) from patients in any given intensive care unit or nursing home are now resistant to three or more antibiotic drugs. (3) This situation is very similar for other pathogenic organisms as well. (4) Currently, very few new antibiotics are in an advanced development stage as a result of fewer large, pharmaceutical companies engaging in antibiotic research and the fact that the successful use of soil-derived antibiotics has, after over 70 years of intensive screening, often resulted in repeated isolation of known compounds. (5) This dire situation has resulted in an increased rate of morbidity and mortality stemming from bacterial infections. (6) In the era of antibiotic resistance, a paradigm shift from the development of new antibiotics via structural modifications to nonconventional antimicrobial alternatives is warranted.
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1021/acs.jmedchem.1c00656">http://doi.org/10.1021/acs.jmedchem.1c00656</a></td>
</tr></tbody></table>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2021
Antimicrobial agents and chemotherapy
Bacteria
Gallium
ions
iron
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejmg.2015.05.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejmg.2015.05.009</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
381-386
Issue
8
Volume
58
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Title
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Exome Sequencing Reveals A Novel Wdr45 Frameshift Mutation And Inherited Polr3a Heterozygous Variants In A Female With A Complex Phenotype And Mixed Brain Mri Findings
Publisher
An entity responsible for making the resource available
European Journal of Medical Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-08
Subject
The topic of the resource
4H syndrome; accumulation; atp13a2 mutations; clinical spectrum; Demyelinating disease; diabetes-mellitus; gene; Genetics & Heredity; hallervorden-spatz-syndrome; hypogonadism; iron; Leukodystrophy; Leukodystrophy; NBIA; neurodegeneration; POLR3A; spastic paraplegia spg35; WDR45; Whole exome sequencing
Creator
An entity primarily responsible for making the resource
Khalifa M; Naffaa L
Description
An account of the resource
WDR45 and POLR3A are newly recognized genes; each is associated with a distinct neurodegenerative disease. WDR45 is an X-linked gene associated with a dominant form of Neurodegeneration with Brain Iron Accumulation (NBIA), manifested by progressive disabilities, dystonia, cognitive decline, spastic paraplegia, neuropsychiatric abnormalities and iron deposition in the basal ganglia on brain imaging. POLR3A, on the other hand, is an autosomal gene, and its mutations cause a recessive form of a hypomyelination with leukodystrophy disease, also known as 4H syndrome, characterized by congenital Hypomyelination with thinning of the corpus callosum, Hypodontia and Hypogonadotropic Hypogonadism. We report on a female child with severe intellectual disability, aphasia, short stature, ataxia, failure to thrive and structural brain abnormalities. Brain MRI obtained in late infancy showed hypomyelination involving the central periventricular white matter and thinning of the corpus callosum with no evidence of iron accumulation. Brain MRI obtained in childhood showed stable hypomyelination, with progressive iron accumulation in the basal ganglia, in particular in the globus pallidus and substantia nigra. Whole Exome Sequencing (WES) identified a novel WDR45 frameshift deleterious mutation in Exon 9 (c.587-588del) and also revealed three POLR3A missense heterozygous variants. The first is a maternally inherited novel missense variant in exon 4 (c.346A > G). Exon 13 carried two heterozygous missense variants, a maternally inherited variant (c.1724A > T) and a paternally inherited variant (1745G > A). These variants are considered likely damaging. The patient's complex clinical phenotype and mixed brain MRI findings might be attributed to the confounding effects of the expression of these two mutant genes. (C) 2015 Elsevier Masson SAS. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejmg.2015.05.009" target="_blank" rel="noreferrer noopener">10.1016/j.ejmg.2015.05.009</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2015
4H syndrome
accumulation
atp13a2 mutations
clinical spectrum
Demyelinating disease
diabetes-mellitus
European journal of medical genetics
gene
Genetics & Heredity
hallervorden-spatz-syndrome
hypogonadism
iron
Journal Article or Conference Abstract Publication
Khalifa M
Leukodystrophy
Naffaa L
NBIA
Neurodegeneration
POLR3A
spastic paraplegia spg35
WDR45
Whole Exome Sequencing
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s10534-014-9790-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10534-014-9790-z</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1291-1301
Issue
6
Volume
27
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Abnormal Metal Levels In The Primary Visual Pathway Of The Dba/2j Mouse Model Of Glaucoma
Publisher
An entity responsible for making the resource available
Biometals
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-12
Subject
The topic of the resource
alzheimers-disease; amyloid-beta; aqueous-humor; Biochemistry & Molecular Biology; ganglion-cell degeneration; gene-expression; Glaucoma; ICP-MS; iron; microarray analysis; neurodegeneration; neurodegeneration; Retina; Retina; Superior colliculus; synapse
Creator
An entity primarily responsible for making the resource
DeToma A S; Dengler-Crish C M; Deb A; Braymer J J; Penner-Hahn J E; Van der Schyf C J; Lim M H; Crish S D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s10534-014-9790-z" target="_blank" rel="noreferrer noopener">10.1007/s10534-014-9790-z</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2014
alzheimers-disease
amyloid-beta
aqueous-humor
Biochemistry & Molecular Biology
Biometals
Braymer J J
Crish S D
Deb A
Dengler-Crish C M
Department of Pharmaceutical Sciences
DeToma A S
ganglion-cell degeneration
gene-expression
Glaucoma
ICP-MS
iron
Lim M H
Microarray Analysis
NEOMED College of Pharmacy
Neurodegeneration
Penner-Hahn J E
retina
superior colliculus
synapse
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/nrd2330" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/nrd2330</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4-4
Issue
6
Volume
6
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Magic bullets or novel multimodal drugs with various CNS targets for Parkinson's disease?
Publisher
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Nature Reviews Drug Discovery
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-06
Subject
The topic of the resource
Biotechnology & Applied Microbiology; disorders; iron; monoamine-oxidase inhibition; neurodegenerative diseases; neurorescue; Pharmacology & Pharmacy; rasagiline
Creator
An entity primarily responsible for making the resource
Youdim M B H; Van der Schyf C J
Identifier
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<a href="http://doi.org/10.1038/nrd2330" target="_blank" rel="noreferrer noopener">10.1038/nrd2330</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2007
Biotechnology & Applied Microbiology
disorders
iron
Journal Article
monoamine-oxidase inhibition
Nature Reviews Drug Discovery
Neurodegenerative Diseases
neurorescue
Pharmacology & Pharmacy
rasagiline
Van der Schyf C J
Youdim M B H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00019048-199307000-00007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00019048-199307000-00007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
273-274
Issue
4
Volume
2
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
VIBRIO-VULNIFICUS SEPTICEMIA SHOULD PROMPT THE SEARCH FOR LIVER-DISEASE
Publisher
An entity responsible for making the resource available
Infectious Diseases in Clinical Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-07
Subject
The topic of the resource
haptoglobin; Immunology; infections; Infectious Diseases; iron
Creator
An entity primarily responsible for making the resource
Raza H; Cutrona A F
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00019048-199307000-00007" target="_blank" rel="noreferrer noopener">10.1097/00019048-199307000-00007</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1993
Cutrona A F
haptoglobin
Immunology
Infections
Infectious Diseases
Infectious Diseases in Clinical Practice
iron
Journal Article
Raza H