1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address n/a Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 117-122 Issue 2 Volume 10 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SYNOVITIS EQUIVALENT TO EROSIONS IN RHEUMATOID-ARTHRITIS - IMPLICATIONS OF SKELETAL ANALYSIS FOR THE CLINICAL MANAGEMENT OF CONTEMPORARY RHEUMATOID-ARTHRITIS Publisher An entity responsible for making the resource available Clinical and Experimental Rheumatology Date A point or period of time associated with an event in the lifecycle of the resource 1992 1992-03 Subject The topic of the resource erosions; hand; joint disease; lesions; mortality; radiographs; radiologic assessment; rats; rheumatoid-arthritis; Rheumatology; skeletal radiology; synoviocytes; therapy; wrist Creator An entity primarily responsible for making the resource Rothschild B M; Woods R J Description An account of the resource Examination of a contemporary skeletal collection revealed a rheumatoid subgroup with parameters mirroring those of contemporary clinical populations. This rheumatoid population was also indistinguishable from contemporary (live) clinical populations, on the basis of the actual distribution of radiologically detectable erosions, thus validating its representativeness. Gross examination of these defleshed skeletons allowed assessment of the significance of erosive disease in rheumatoid arthritis. As anticipated, the frequency of visibly detectable erosions exceeded that detectable radiologically. The frequency of visibly detectable erosions, however, was indistinguishable from the frequency of synovitis in clinical populations. The excellent correlation of the gross and clinical distribution of disease suggests that some degree of erosive disease is integral to all lesions of rheumatoid arthritis and that only the relative insensitivity of radiologic techniques precludes universal recognition of those erosions. This work suggests that any therapeutic intervention which settles for only partial synovitis control will not prevent the progression of erosive disease; and perhaps explains the difficulty of demonstrating alterations in erosion progression in studies of disease modifying agents. Identifier An unambiguous reference to the resource within a given context n/a Format The file format, physical medium, or dimensions of the resource Journal Article 1992 Clinical and experimental rheumatology erosions Hand joint disease Journal Article lesions Mortality Radiographs radiologic assessment Rats rheumatoid-arthritis Rheumatology Rothschild B M skeletal radiology synoviocytes therapy Woods R J wrist