1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fnins.2017.00146" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnins.2017.00146</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
19-19
Volume
11
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma
Publisher
An entity responsible for making the resource available
Frontiers in Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
amyotrophic-lateral-sclerosis; axon; axonopathy; glucose-transporter glut3; glycogen-synthase kinase-3; lactate; Mitochondria; monocarboxylate transporters; mouse white-matter; neuron lactate-shuttle; neuropathy; Neurosciences & Neurology; optic; optic-nerve head; retinal ganglion-cells; self-destruction; slow wallerian degeneration; Wallerian degeneration
Creator
An entity primarily responsible for making the resource
Inman D M; Harun-Or-Rashid M
Description
An account of the resource
Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even seemingly subtle modifications of metabolism can result in functional deficits and degeneration. Axons require a great deal of energy, up to 70% of all energy used by a neuron, just to maintain the resting membrane potential. Axonal energy, in the form of ATP, is generated primarily through oxidative phosphorylation in the mitochondria. In addition, glial cells contribute metabolic intermediates to axons at moments of high activity or according to need. Recent evidence suggests energy disruption is an early contributor to pathology in a wide variety of neurodegenerative disorders characterized by axonopathy. However, the degree to which the energy disruption is intrinsic to the axon vs. associated glia is not clear. This paper will review the role of energy availability and utilization in axon degeneration in glaucoma, a chronic axonopathy of the retinal projection.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fnins.2017.00146" target="_blank" rel="noreferrer noopener">10.3389/fnins.2017.00146</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
amyotrophic-lateral-sclerosis
axon
Axonopathy
Department of Pharmaceutical Sciences
Frontiers in neuroscience
glucose-transporter glut3
glycogen-synthase kinase-3
Harun-Or-Rashid M
Inman D M
Journal Article or Conference Abstract Publication
lactate
Mitochondria
monocarboxylate transporters
mouse white-matter
NEOMED College of Pharmacy
neuron lactate-shuttle
Neuropathy
Neurosciences & Neurology
optic
optic-nerve head
retinal ganglion-cells
self-destruction
slow wallerian degeneration
Wallerian degeneration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.109.3.756" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.109.3.756</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
756-760
Issue
3
Volume
109
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopexamine Hydrochloride In Septic Shock
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
consumption; dobutamine; dopexamine hydrochloride; endotoxic dogs; General & Internal Medicine; heart failure; infusion; inotropic support; lactate; muscle; O-2 transport; O-2 uptake; optimal values; oxygen delivery; Respiratory System; respiratory-distress syndrome; sepsis; septic shock; tissue oxygenation; volume support
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Meierhellmann A; Wallenfang G; Bredle D L
Description
An account of the resource
Objective: To test whether dopexamine hydrochloride, by its beta(2)-adrenoceptor and dopaminergic 1 (DA(1)) and dopaminergic 2 (DA(2)) agonistic properties, can improve oxygen consumption (V over dot O-2) in hyperdynamic patients with septic shock. Design: Prospective, single-cohort study. Setting: ICU, university hospital. Patients: Twenty-nine postoperative, hemodynamically stabilized, hyperdynamic patients with septic shock. Interventions: Short-term application (30 min) of dopexamine hydrochloride at a dose of 2 mu g/kg/min. Measurements: Complete hemodynamic profile with O-2 transport-related variables at baseline, 30 min after starting the dopexamine infusion, and 30 min after stopping the infusion. Main results: The dopexamine infusion resulted in significant increases in cardiac index (17%) (p<0.001) and O-2 delivery (DO2) (16%) (p<0.001), V over dot O-2 increased slightly but significantly about 4% (p<0.01) by respiratory gas exchange measurements and 9% (p<0.01) by cardiovascular Fick calculations. The O-2 extraction ratio decreased about 8% (0.001). Conclusions: The addition of dopexamine hydrochloride at a dose of 2 mu g/kg/min resulted in significant increases of DO2 and to a lesser extent V over dot O-2. Much of the global DO2 increase was not utilized, because O-2 extraction ratio decreased. Direct calorigenic effects of dopexamine and an increase in myocardial V over dot O-2 likely account for a large portion of the increase in global V over dot O-2. Whether any of the V over dot O-2 increase reflects improvement in regions of jeopardized tissue oxygenation remains to be clarified before the definite value of this lug in septic shock can be established.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.109.3.756" target="_blank" rel="noreferrer noopener">10.1378/chest.109.3.756</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bredle D L
Chest
consumption
dobutamine
dopexamine hydrochloride
endotoxic dogs
General & Internal Medicine
Hannemann L
Heart failure
infusion
inotropic support
Journal Article or Conference Abstract Publication
lactate
Meierhellmann A
Muscle
O-2 transport
O-2 uptake
optimal values
oxygen delivery
Reinhart K
Respiratory System
respiratory-distress syndrome
sepsis
Septic shock
tissue oxygenation
volume support
Wallenfang G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.105.5.1504" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.105.5.1504</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1504-1510
Issue
5
Volume
105
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prostacyclin In Septic Shock
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-05
Subject
The topic of the resource
critically; delivery; failure; General & Internal Medicine; ill patients; increases oxygen-consumption; infusion; lactate; norepinephrine therapy; Respiratory System; respiratory-distress syndrome; sepsis; tissue oxygenation
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Meierhellmann A; Bredle D L
Description
An account of the resource
Objective: Investigation of the hypothesis that the infusion of 10 ng/kg/min prostacyclin (epoprostenol) (PGI(2)) improves O-2 uptake in patients with hyperdynamic septic shock. Design: Prospective, single cohort design. Setting: ICU, university hospital. Patients: Fifteen postoperative patients with septic shock. Interventions: Infusion of 10 ng/kg/min of PGI(2) for 60 min. Measurements: Complete hemodynamic profile with O-2 transport-related variables (simultaneous measurements of Vo(2) from the respiratory gases and by cardiovascular Fick) and blood lactate levels before start of the PGI(2)-infusion and 60 min thereafter. Main results: Oxygen delivery increased significantly (14 percent) from its already high value, 750+/-238 to 852+/-214 ml/min/m(2). The O-2 extraction ratio remained unchanged. When Vo(2) was measured from the respiratory gases, it was unchanged. When Vo(2) was measured by cardiovascular Fick, it increased slightly (p<0.05). Conclusions: We conclude that in this O-2 challenge test with PGI(2) in patients with septic shock, an increase in O-2 delivery was not matched by an increase in Vo(2). We believe that the adequate conventional support of these patients may have prevented the PGI(2) from revealing a ''covert'' O-2 debt. The PGI(2) test did not predict mortality by O-2 supply dependency. The small increase in Vo(2) as calculated indirectly suggests a degree of mathematical coupling of O-2 delivery and uptake.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.105.5.1504" target="_blank" rel="noreferrer noopener">10.1378/chest.105.5.1504</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Bredle D L
Chest
critically
Delivery
failure
General & Internal Medicine
Hannemann L
ill patients
increases oxygen-consumption
infusion
Journal Article or Conference Abstract Publication
lactate
Meierhellmann A
norepinephrine therapy
Reinhart K
Respiratory System
respiratory-distress syndrome
sepsis
tissue oxygenation