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Text
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URL Address
<a href="http://doi.org/10.1016/s0006-8993(01)03113-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(01)03113-4</a>
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Pages
160-164
Issue
1
Volume
921
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Dublin Core
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Title
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Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice
Publisher
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Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-12
Subject
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brain; catecholamine; dopaminergic activity; exercise; fatigue; left ventricle; mechanisms; metabolism; Neurosciences & Neurology; nigrostriatal; performance; physical exercise; rats; responses; serotonin
Creator
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Kalinski M I; Dluzen D E; Stadulis R
Description
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Treatment with methamphetamine (MA - 20 mg/kgx4 i.p. at 2-h intervals) or its vehicle at 7 days prior to tests of running time to exhaustion were evaluated in 60-day-old CD-1 male mice. Pre-treatment running times were not significantly different between the two groups. MA resulted in significantly decreased running times to exhaustion compared to vehicle-treated controls and a significant reduction in corpus striatal dopamine and DOPAC but not norepinephrine. No statistically significant differences in catecholamines were obtained within the hypothalamus, or left ventricle of the heart, nor were body weights significantly different between these groups. The data show that a regimen of MA, which results in an approximate 90% depletion of striatal DA. produces a reduction in running time to exhaustion. (C) 2001 Elsevier Science B.V. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/s0006-8993(01)03113-4" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(01)03113-4</a>
Format
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Journal Article or Conference Abstract Publication
2001
Brain
Brain research
catecholamine
Dluzen D E
dopaminergic activity
Exercise
fatigue
Journal Article or Conference Abstract Publication
Kalinski M I
left ventricle
mechanisms
Metabolism
Neurosciences & Neurology
nigrostriatal
Performance
physical exercise
Rats
responses
serotonin
Stadulis R