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Text
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URL Address
<a href="http://doi.org/10.1111/j.1471-4159.1992.tb10048.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1471-4159.1992.tb10048.x</a>
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Pages
1736-1742
Issue
5
Volume
58
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Title
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DOPAMINERGIC MODULATION OF GLUTAMATE RELEASE IN STRIATUM AS MEASURED BY MICRODIALYSIS
Publisher
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Journal of Neurochemistry
Date
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1992
1992-05
Subject
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afferents; amino-acid neurotransmitters; aspartate; Biochemistry & Molecular Biology; brain-tissue; corticostriatal path; d2 receptors; dopamine; endogenous glutamate; glutamate; in-vivo; lesion; microdialysis; nerve-terminals; Neurosciences & Neurology; pathway; rat caudate-putamen
Creator
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Yamamoto B K; Davy S
Description
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Glutamate and aspartate are the primary neurotransmitters of projections from motor and premotor cortices to the striatum. Release of glutamate may be modulated by dopamine receptors located on corticostriatal terminals. The present study used microdialysis to investigate the dopaminergic modulation of in vivo striatal glutamate and aspartate release in the striatum of awake-behaving rats. Local perfusion with a depolarizing concentration of K+ through a dialysis probe into the rat striatum produced a significant increase in the release of glutamate, aspartate, and taurine. The D2 agonist LY171555 blocked the K+-induced release of glutamate and aspartate, but not taurine, in a concentration-dependent manner. The D1 agonist SKF 38393 did not alter K+-induced release of glutamate and taurine, but did significantly decrease aspartate release. Neither agonist had any effect on basal amino acid release. The D2 antagonist (-)-sulpiride reversed the inhibitory effects of LY 171555 on K+-induced glutamate release. These results provide in vivo evidence for a functional interaction between dopamine, the D2 receptor, and striatal glutamate release.
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<a href="http://doi.org/10.1111/j.1471-4159.1992.tb10048.x" target="_blank" rel="noreferrer noopener">10.1111/j.1471-4159.1992.tb10048.x</a>
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Journal Article
1992
afferents
amino-acid neurotransmitters
aspartate
Biochemistry & Molecular Biology
brain-tissue
corticostriatal path
d2 receptors
Davy S
Dopamine
endogenous glutamate
glutamate
in-vivo
Journal Article
Journal of neurochemistry
lesion
Microdialysis
nerve-terminals
Neurosciences & Neurology
pathway
rat caudate-putamen
Yamamoto B K