1
40
1
-
Text
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n/a
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Pages
32-35
Issue
1
Volume
10
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Title
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SEROLOGIC REACTIVITY AGAINST MYCOBACTERIUM-PARATUBERCULOSIS ANTIGENS IN PATIENTS WITH SARCOIDOSIS
Publisher
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Sarcoidosis
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-03
Subject
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antibodies; crohns-disease; crohns-disease; elisa; elisa assay; inflammatory bowel disease; linked immunosorbent-assay; mycobacterium-paratuberculosis; Respiratory System; tuberculosis
Creator
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Reid J D; Chiodini R J
Description
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Although sarcoidosis has clinical and histopathologic similarities to some forms of tuberculosis and other mycobacterial infections, attempts to establish a mycobacterial etiology have not been successful. Using cytoplasmic antigens derived from a wild strain of Mycobacterium paratuberculosis in an enzyme-linked immunosorbent assay, patients with sarcoidosis were found to have immunoglobulin levels significantly higher than those found in a control population in the IgG, but not in IgA or IgM antibody classes. Results were comparable to those reported from patients with Crohn's disease, where M. paratuberculosis has been intensively studied as a possible etiologic agent. To elucidate these relationships, examination of DNA from sarcoid tissues for possible homology with DNA from M. paratuberculosis and closely related organisms, as well as cultural attempts with techniques and media appropriate for M. paratuberculosis may be warranted.
Identifier
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n/a
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Journal Article
1993
Antibodies
Chiodini R J
crohns-disease
elisa
elisa assay
inflammatory bowel disease
Journal Article
linked immunosorbent-assay
mycobacterium-paratuberculosis
Reid J D
Respiratory System
Sarcoidosis
Tuberculosis