1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a></td>
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NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Update Year & Number
Jan to Aug list 2021
Dublin Core
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Title
A name given to the resource
Chapter 20 - Molecular insights into anatomy and physiology
Creator
An entity primarily responsible for making the resource
Cooper LN; Gorbunova V
Publisher
An entity responsible for making the resource available
The Bowhead Whale
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
Description
An account of the resource
Bowhead whales are some of the largest animals that occupy the Arctic Circle. Despite the challenges of living and giving birth in icy waters, having huge blubber stores, eating a fat-rich diet, and undergoing arduous migrations, bowheads achieved the longest known life span of mammals of 268 years. Their longevity is extended by fixed mutations that prevent DNA damage and cancer and through evolutionary modifications to their metabolism that compensate for an oxygen-poor environment. Recently, the bowhead genome and transcriptome libraries were made publicly available for study. Analyses suggest that their life span has been extended by evolutionary changes that result in the upregulation of DNA repair pathways. Molecular biologists are now undertaking laboratory experiments with whale samples that are informed by the bowhead genome and transcriptome to tackle questions that were inaccessible using classical model organisms such as rodents or fish. Biomedical researchers are also applying insights gained from research on bowheads into investigations of potential therapies for aging, senescence, and cancer. Moreover, researchers are using these results to inform our understanding of the evolutionary history of these traits. This chapter reviews the molecular basis for bowhead whale longevity and survival in their unique habitat and offers insights for further exploration into the molecular mechanisms that shape the extraordinary lives of these animals.
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a></td>
</tr></tbody></table>
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2021
Balaena mysticetus
Blubber
bowhead whale
DNA
lipid
longevity
molecular evolution
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a>
Pages
299-307
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/B978-0-12-818969-6.00020-0</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chapter 20 - Molecular insights into anatomy and physiology
Publisher
An entity responsible for making the resource available
The Bowhead Whale
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-01-01
Subject
The topic of the resource
DNA; lipid; blubber; Bowhead whale; Balaena mysticetus; molecular evolution; longevity
Creator
An entity primarily responsible for making the resource
Cooper LN; Gorbunova V
Description
An account of the resource
Bowhead whales are some of the largest animals that occupy the Arctic Circle. Despite the challenges of living and giving birth in icy waters, having huge blubber stores, eating a fat-rich diet, and undergoing arduous migrations, bowheads achieved the longest known life span of mammals of 268 years. Their longevity is extended by fixed mutations that prevent DNA damage and cancer and through evolutionary modifications to their metabolism that compensate for an oxygen-poor environment. Recently, the bowhead genome and transcriptome libraries were made publicly available for study. Analyses suggest that their life span has been extended by evolutionary changes that result in the upregulation of DNA repair pathways. Molecular biologists are now undertaking laboratory experiments with whale samples that are informed by the bowhead genome and transcriptome to tackle questions that were inaccessible using classical model organisms such as rodents or fish. Biomedical researchers are also applying insights gained from research on bowheads into investigations of potential therapies for aging, senescence, and cancer. Moreover, researchers are using these results to inform our understanding of the evolutionary history of these traits. This chapter reviews the molecular basis for bowhead whale longevity and survival in their unique habitat and offers insights for further exploration into the molecular mechanisms that shape the extraordinary lives of these animals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener"></a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2021
Balaena mysticetus
Blubber
bowhead whale
Cooper LN
Department of Anatomy & Neurobiology
DNA
Gorbunova V
January 2021 List
journalArticle
lipid
longevity
molecular evolution
NEOEMD College of Medicine
The Bowhead Whale
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0009-3084(96)02574-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0009-3084(96)02574-1</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
147-162
Issue
2
Volume
82
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of 1-palmitoyl lysophosphatidylcholine on phase properties of 1,2-dipalmitoyl phosphatidylethanolamine: A thermodynamic and NMR study
Publisher
An entity responsible for making the resource available
Chemistry and Physics of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-08
Subject
The topic of the resource
Biophysics; Biochemistry & Molecular Biology; cholesterol; fusion; lysolecithin; lipid; membranes; bilayer; H-2-NMR; transition; nuclear-magnetic-resonance; phosphatidylcholine vesicles; lecithin; bilayers; DSC; mixtures; P-31-NMR; phosphatidylethanolamine
Creator
An entity primarily responsible for making the resource
Checchetti A; Golemme A; Chidichimo G; LaRosa C; Grasso D; Westerman P W
Description
An account of the resource
The effect of 1-palmitoyl lysophosphatidylcholine (PLPC) on the phase behaviour of 1,2-dipalmitoyl phosphatidylethanolamine (DPPE) in excess water (34 wt%) has been examined by differential scanning calorimetry, scanning dilatometry and isothermal compressibility measurements. Mole percentages of PLPC in DPPE between 14 and 62% have been studied over the temperature range 30-75 degrees C. The temperature dependence of orientational ordering at selected sites in H-2-labelled PLPC and 2H(2)O has been determined from measurement of time-averaged chemical shift anisotropies and quadrupole splittings in the P-31- and H-2-NMR spectra. These data have been used to further characterize phase behaviour. At less than equimolar contents of PLPC, when a single phase transition with a reduced transition temperature is observed, spectral and calorimetric data indicate complete miscibility of the two lipid components. An equimolar mixture of PLPC and DPPE shows a sharp first order transition at 47.3 degrees C and a second order transition at 62.5 degrees C. NMR data are consistent with the existence of a defective bilayer at intermediary temperatures. In this range it is proposed that PLPC molecules prefer regions with high curvature in the vicinity of the defects, while DPPE molecules are mostly confined to flatter regions of the bilayer. A possible molecular model is described, At temperatures above 62.5 degrees C, PLPC and DPPE are completely miscible and exist as lamellae. At higher PLPC content (> 50 mol%), thermodynamic and spectral data are indicative of phase separation of the two components over the temperature range examined.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0009-3084(96)02574-1" target="_blank" rel="noreferrer noopener">10.1016/0009-3084(96)02574-1</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
bilayer
bilayers
Biochemistry & Molecular Biology
Biophysics
Checchetti A
Chemistry and Physics of Lipids
Chidichimo G
Cholesterol
DSC
fusion
Golemme A
Grasso D
H-2-NMR
Journal Article or Conference Abstract Publication
LaRosa C
LECITHIN
lipid
lysolecithin
membranes
mixtures
nuclear-magnetic-resonance
P-31-NMR
phosphatidylcholine vesicles
phosphatidylethanolamine
transition
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0005-2736(93)90401-k" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0005-2736(93)90401-k</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
163-169
Issue
2
Volume
1153
Search for Full-text
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Dublin Core
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Title
A name given to the resource
AMINO-ACID SUBSTITUTIONS IN THE MEMBRANE-BINDING DOMAIN OF CYTOCHROME B(5) ALTER ITS MEMBRANE-BINDING PROPERTIES
Publisher
An entity responsible for making the resource available
Biochimica Et Biophysica Acta
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-12
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biophysics; cytochrome b(5); fluorescence; hydrophobicity; lipid; mechanism; membrane binding; phosphatidylcholine vesicles; site-directed mutagenesis; topography; transform infrared-spectroscopy; vesicle
Creator
An entity primarily responsible for making the resource
Tretyachenkoladokhina V G; Ladokhin A S; Wang L M; Steggles A W; Holloway P W
Description
An account of the resource
The structure-function relationships of the 43-amino-acid membrane-binding domain of cytochrome b(5) have been examined in two mutant forms of the protein. In one mutant, two tryptophans in the membrane-binding domain, at positions 108 and 112, were replaced by leucines, and in the second mutant, in addition, aspartic acid 103 was also replaced by leucine. The fluorescence emission spectra of the three proteins and their degree of quenching by brominated lipids indicate that the mutations are not producing major conformational changes or allowing a deeper degree of penetration of the domain into the bilayer. The hydrophobicities of the three proteins were compared, by determining strengths of self-association and membrane affinities, and it was found that the protein with two additional leucines was much less hydrophobic and the one with three additional leucines was much more hydrophobic than the native cytochrome. It appears that small changes in amino acid composition, which produce no gross changes in the structure of the membrane-binding domain, will nevertheless produce very large changes in the strengths of self- and membrane-association. These differences in self-association had profound effects on the times required for membrane-association to reach equilibrium.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0005-2736(93)90401-k" target="_blank" rel="noreferrer noopener">10.1016/0005-2736(93)90401-k</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1993
Biochemistry & Molecular Biology
Biochimica et biophysica acta
Biophysics
cytochrome b(5)
Fluorescence
Holloway P W
hydrophobicity
Journal Article
Ladokhin A S
lipid
mechanism
membrane binding
phosphatidylcholine vesicles
site-directed mutagenesis
Steggles A W
topography
transform infrared-spectroscopy
Tretyachenkoladokhina V G
vesicle
Wang L M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0009-3084(96)02590-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0009-3084(96)02590-x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
25-37
Issue
1
Volume
83
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Title
A name given to the resource
Disposition of chloroform in phosphatidylcholine membranes: A H-2- and P-31-NMR study
Publisher
An entity responsible for making the resource available
Chemistry and Physics of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-09
Subject
The topic of the resource
anesthesia; bilayer; Biochemistry & Molecular Biology; Biophysics; chloroform-membrane interaction; choline head group; deuterium; general-anesthetics; H-2-NMR; headgroup region; inhalation anesthetics; lipid; membrane; model membranes; nuclear magnetic-resonance; phase-transition; phospholipid; phospholipid-membranes
Creator
An entity primarily responsible for making the resource
Phonphok N; Chidichimo G; Westerman P W
Description
An account of the resource
The interaction of chloroform with bilayers of dimyristoylphosphatidylcholine (DMPC) has been studied by deuterium and phosphorus-31 nuclear magnetic resonance (NMR). Orientational order has been measured as a function of temperature at many sites in DMPC, water and chloroform for aqueous multilamellar dispersions of the lipid. At equivalent temperatures above the main phase transition temperature for a molar ratio of DMPC to chloroform of approximately 10 to 1, disordering at several sites in the head group of DMPC is observed, unlike the acyl chains where no disordering is observed. With higher concentrations of chloroform (DMPC/chloroform approximate to 4:1) greater disordering occurs at the same head group sites and is accompanied by disordering of the acyl chains. The pattern of solvent-induced changes in DMPC is similar to that produced by benzyl alcohol and n-alkanols. With H-2-labelled chloroform. the H-2-NMR spectra show two components, one isotropic and the other ordered (Delta v approximate to 1.5 kHz) arising from solute intercalated in the bilayer. In DMPC/water systems at low hydration the ordering of the (H2O)-H-2 in the L(alpha) phase is little affected by chloroform at comparable temperatures whereas at temperatures below the main phase temperature a large disordering of the water is observed. A model of the mode of interaction between chloroform and DMPC is proposed, in which the chloroform is localized principally in an ordered environment in the vicinity of the choline head group at lower temperatures and solute concentrations. Increasing either of these parameters favors the penetration of the chloroform into the center of the bilayer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0009-3084(96)02590-x" target="_blank" rel="noreferrer noopener">10.1016/0009-3084(96)02590-x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1996
Anesthesia
bilayer
Biochemistry & Molecular Biology
Biophysics
Chemistry and Physics of Lipids
Chidichimo G
chloroform-membrane interaction
choline head group
Deuterium
general-anesthetics
H-2-NMR
headgroup region
inhalation anesthetics
Journal Article
lipid
membrane
model membranes
nuclear magnetic-resonance
phase-transition
Phonphok N
phospholipid
phospholipid-membranes
Westerman P W