1
40
4
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.2001.90.4.1489" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.2001.90.4.1489</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1489-1496
Issue
4
Volume
90
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats
Publisher
An entity responsible for making the resource available
Journal of Applied Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-04
Subject
The topic of the resource
anesthetized sheep; cation channels; channels; conductance; cyclic nucleotide-gated cation channels; dibutyryl-guanosine-3'5'-cyclic monophosphate; distal lung; epithelial na+ channel; epithelial sodium ion; guinea-pigs; isoproterenol; l-cis-diltiazem; lung liquid clearance; Physiology; protein clearance; sodium transport; Sport Sciences; terbutaline
Creator
An entity primarily responsible for making the resource
Norlin A; Lu L N; Guggino S E; Matthay M A; Folkesson H G
Description
An account of the resource
The contributions of amiloride-sensitive and -insensitive fractions of alveolar fluid clearance in adult ventilated rats were studied under control conditions and after beta -adrenergic stimulation. Rats were instilled with a 5% albumin solution containing terbutaline (10(-4) M) or dibutyryl-cGMP (DBcGMP; 10-4 M) with or without the cyclic nucleotide-gated cation channel inhibitor l-cis-diltiazem (10(-3) M) and/or amiloride (10-3 M). Alveolar fluid clearance over 1 h was 18 +/- 2% in controls. In controls, amiloride inhibited 46 +/- 15% of alveolar fluid clearance, whereas l-cis-diltiazem had no inhibitory effect. Terbutaline and DBcGMP stimulated alveolar fluid clearance by 85 +/- 3 and 36 +/- 5%, respectively. Amiloride and l-cis-diltiazem inhibited nearly equal fractions of terbutaline-stimulated alveolar fluid clearance when given alone. Amiloride and l-cis-diltiazem given together inhibited a significantly larger fraction of alveolar fluid clearance in terbutaline-stimulated rats and in DBcGMP-stimulated rats. Based on these data, tertbutaline stimulation recruited both amiloride-sensitive and E-cis-diltiazem-sensitive pathways. In contrast, DBcGMP mainly recruited l-cis-diltiazem-sensitive pathways. Therefore, the amiloride-insensitive fraction of Nat-driven alveolar fluid clearance may be partly mediated through cyclic nucleotide-gated cation channels and activated by an increase in intracellular cGMP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.2001.90.4.1489" target="_blank" rel="noreferrer noopener">10.1152/jappl.2001.90.4.1489</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
anesthetized sheep
cation channels
channels
conductance
cyclic nucleotide-gated cation channels
dibutyryl-guanosine-3'5'-cyclic monophosphate
distal lung
epithelial na+ channel
epithelial sodium ion
Folkesson H G
Guggino S E
guinea-pigs
isoproterenol
Journal Article
Journal of Applied Physiology
l-cis-diltiazem
Lu L N
lung liquid clearance
Matthay M A
Norlin A
Physiology
protein clearance
sodium transport
Sport Sciences
terbutaline
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.2001.280.4.l606" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.2001.280.4.l606</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L606-L616
Issue
4
Volume
280
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alveolar fluid clearance in late-gestational guinea pigs after labor induction: mechanisms and regulation
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-04
Subject
The topic of the resource
absorption; adrenaline; alveolar epithelium; beta-adrenergic stimulation; birth; catecholamines; developmental-changes; distress syndrome; epinephrine; fetal sheep; infant respiratory; lung liquid clearance; newborn rabbits; Physiology; prenatal development; Respiratory System; sodium transport; transport; ventilated rats
Creator
An entity primarily responsible for making the resource
Norlin A; Folkesson H G
Description
An account of the resource
We tested the hypothesis that labor-induced epinephrine release would stimulate alveolar fluid clearance in preterm fetuses. Preterm fetuses were obtained by cesarean section from timed-pregnant guinea pigs at 61-69 days postconception. Fetal guinea pigs were euthanized and placed on continuous positive airway pressure oxygenation, and an isosmolar 5% albumin solution was instilled. Alveolar fluid clearance was measured over 1 h. The fetal lung began to absorb fluid at 64-66 days postconception, and at birth, alveolar fluid clearance quadrupled. Baseline alveolar fluid clearance when present was sensitive to propranolol inhibition and depended on beta -adrenergic stimulation. Measurements of plasma epinephrine in fetal animals confirmed high epinephrine levels in 66- to 69-day postconception fetuses. Prenatal alveolar fluid clearance when present was highly amiloride sensitive, suggesting that amiloride-sensitive Na+ channels were critical. Oxytocin-induced labor initiated an amiloride- and propranolol-sensitive net alveolar fluid clearance in 61-day-gestation animals. Moreover, oxytocin induced significant epinephrine release in all fetuses. These results have clinical implications for infants delivered by cesarean section before the onset of labor. Use of pharmacological agents to induce labor may reduce the occurrence and severity of perinatal respiratory distress.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.2001.280.4.l606" target="_blank" rel="noreferrer noopener">10.1152/ajplung.2001.280.4.l606</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
Absorption
adrenaline
alveolar epithelium
American Journal of Physiology-Lung Cellular and Molecular Physiology
beta-adrenergic stimulation
birth
catecholamines
developmental-changes
distress syndrome
Epinephrine
fetal sheep
Folkesson H G
infant respiratory
Journal Article
lung liquid clearance
newborn rabbits
Norlin A
Physiology
prenatal development
Respiratory System
sodium transport
transport
ventilated rats
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00445.2010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00445.2010</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L804-L811
Issue
5
Volume
301
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Phosphatidylinositol 4,5-bisphosphate Stimulates Alveolar Epithelial Fluid Clearance In Male And Female Adult Rats
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
5-bisphosphate; absorption; acute lung injury; alpha; alveolar epithelial barrier; amiloride; beta; beta-adrenoceptor agonists; catecholamines; female advantage; in alveolar fluid clearance; lung liquid clearance; na+ channel enac; permeability; phosphatidylinositol-4; Physiology; pulmonary edema; Respiratory System; rna interference; sodium transport; sodium-channel; transport; water
Creator
An entity primarily responsible for making the resource
Kooijman E E; Kuzenko S R; Gong D H; Best M D; Folkesson H G
Description
An account of the resource
Kooijman EE, Kuzenko SR, Gong D, Best MD, Folkesson HG. Phosphatidylinositol 4,5-bisphosphate stimulates alveolar epithelial fluid clearance in male and female adult rats. Am J Physiol Lung Cell Mol Physiol 301: L804-L811, 2011. First published August 26, 2011; doi:10.1152/ajplung.00445.2010.-Cell membrane phospholipids, like phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2], can regulate epithelial Na channel (ENaC) activity. Gender differences in lung ENaC expression have also been demonstrated. However, the effects in vivo on alveolar fluid clearance are uncertain. Thus PI(4,5)P-2 effects on alveolar fluid clearance were studied in male and female rats. An isosmolar 5% albumin solution was intrapulmonary instilled; alveolar fluid clearance was studied for 1 h. Female rats had a 37 +/- 19% higher baseline alveolar fluid clearance than male rats. Bilateral ovariectomy attenuated this gender difference. Compared with controls, PI(4,5)P-2 instillation (300 mu M) increased alveolar fluid clearance by similar to 93% in both genders. Amiloride or the specific alpha ENaC small-interfering RNA inhibited baseline and PI(4,5)P-2-stimulated alveolar fluid clearance in both genders, indicating a dependence on amiloride-sensitive pathways. The fraction of amiloride inhibition was greater in PI(4,5)P-2-instilled rats (male: 64 +/- 10%; female: 70 +/- 11%) than in controls (male: 30 +/- 6%; female: 44 +/- 8%). PI(4,5)P-2 instillation lacked additional alveolar fluid clearance stimulation above that of terbutaline, nor did propranolol inhibit alveolar fluid clearance after PI(4,5)P-2 instillation, indicating that PI(4,5)P-2 stimulation was not secondary to endogenous beta-adrenoceptor activation. PI(4,5)P-2 amine instillation resulted in an intermediate alveolar fluid clearance stimulation, suggesting that, to reach maximal alveolar fluid clearance stimulation, PI(4,5)P-2 must reside in cell membranes. In summary, PI(4,5)P-2 instillation upregulated in vivo alveolar fluid clearance similar to short-term beta-adrenoceptor upregulation of alveolar fluid clearance. PI(4,5)P-2 stimulation was mediated partly by increased amiloride-sensitive Na transport. There exist important gender-related effects suggesting a female advantage that may have clinical implications for resolution of acute lung injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00445.2010" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00445.2010</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
5-bisphosphate
Absorption
acute lung injury
alpha
alveolar epithelial barrier
American Journal of Physiology-Lung Cellular and Molecular Physiology
amiloride
Best M D
beta
beta-adrenoceptor agonists
catecholamines
female advantage
Folkesson H G
Gong D H
in alveolar fluid clearance
Journal Article or Conference Abstract Publication
Kooijman E E
Kuzenko S R
lung liquid clearance
na+ channel enac
Permeability
phosphatidylinositol-4
Physiology
pulmonary edema
Respiratory System
RNA Interference
sodium transport
sodium-channel
transport
Water
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/hh2201.100204" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/hh2201.100204</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
907-914
Issue
10
Volume
89
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta(2)-adrenergic Receptor Overexpression Increases Alveolar Fluid Clearance And Responsiveness To Endogenous Catecholamines In Rats
Publisher
An entity responsible for making the resource available
Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-11
Subject
The topic of the resource
a549 cells; adenovirus; alveolar solute transport; beta(2)-adrenergic receptor; Cardiovascular System & Cardiology; epithelium; expression; gene transfer; Hematology; inhibitor; lung liquid clearance; mediated gene-transfer; pulmonary edema; stimulation; therapy; transport; ventricular myocytes
Creator
An entity primarily responsible for making the resource
Dumasius V; Sznajder J I; Azzam Z S; Boja J; Mutlu G M; Maron M B; Factor P
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/hh2201.100204" target="_blank" rel="noreferrer noopener">10.1161/hh2201.100204</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2001
a549 cells
adenovirus
alveolar solute transport
Azzam Z S
beta(2)-adrenergic receptor
Boja J
Cardiovascular System & Cardiology
Circulation research
Dumasius V
Epithelium
expression
Factor P
gene transfer
Hematology
inhibitor
lung liquid clearance
Maron M B
mediated gene-transfer
Mutlu G M
pulmonary edema
Stimulation
Sznajder J I
therapy
transport
ventricular myocytes