Early postoperative complications in lung transplant recipients
Lung transplantation has become an established therapy for end-stage lung diseases. Early postoperative complications can impact immediate, mid-term, and long-term outcomes. Appropriate management, prevention, and early detection of these early postoperative complications can improve the overall transplant course. In this review, we highlight the incidence, detection, and management of these early postoperative complications in lung transplant recipients.
Vanessa Soetanto
Udhayvir Singh Grewal
Atul C Mehta
Parth Shah
Manu Varma
Delyse Garg
Tilottama Majumdar
Neha S Dangayach
Harpreet Singh Grewal
Indian J Thorac Cardiovasc Surg
. 2022 Jul;38(Suppl 2):260-270. doi: 10.1007/s12055-021-01178-1. Epub 2021 Jun 9.
2022
English
Early postoperative complications in lung transplant recipients.
Lung transplantation has become an established therapy for progressive end-stage lung diseases refractory to maximal medical management. The immediate post-transplantation phase is crucial in determining short- and long-term survival and, ultimately, the quality of life of a lung transplant recipient. We continue to learn the risk factors and strategies to mitigate postoperative complications. Here, we present a concise review on the diagnosis and management of medical and surgical complications in the postoperative period, with major complications summarized in Table 1.
Lung transplantation has become an established therapy for end-stage lung diseases. Early postoperative complications can impact immediate, mid-term, and long-term outcomes. Appropriate management, prevention, and early detection of these early postoperative complications can improve the overall transplant course. In this review, we highlight the incidence, detection, and management of these early postoperative complications in lung transplant recipients.
Soetanto V; Grewal US; Mehta AC; Shah P; Varma M; Garg D; Majumdar T; Dangayach NS; Grewal HS
Indian Journal Of Thoracic And Cardiovascular Surgery
2021
2021-06-09
Journal Article
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Early postoperative complications in lung transplant recipients.
Complications; Lung transplantation; Postoperative
Lung transplantation has become an established therapy for end-stage lung diseases. Early postoperative complications can impact immediate, mid-term, and long-term outcomes. Appropriate management, prevention, and early detection of these early postoperative complications can improve the overall transplant course. In this review, we highlight the incidence, detection, and management of these early postoperative complications in lung transplant recipients.
Soetanto V; Grewal US; Mehta AC; Shah P; Varma M; Garg D; Majumdar T; Dangayach NS; Grewal HS
Indian Journal Of Thoracic And Cardiovascular Surgery
2021
2021-06-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1007/s12055-021-01178-1" target="_blank" rel="noreferrer noopener">10.1007/s12055-021-01178-1</a>
Cystic Fibrosis Patients With And Without Central Nervous System Complications Following Lung Transplantation
CNS complications; convulsions; cyclosporin neurotoxicity; cyclosporine; cystic fibrosis; heart-transplantation; hyponatremia; liver; lung transplantation; methylprednisolone; neurologic complications; Pediatrics; receiving; recipients; Respiratory System; seizures; stroke; toxicity
Goldstein A B; Goldstein L S; Perl M K; Haug M T; Arroliga A C; Stillwell P C
Pediatric Pulmonology
2000
2000-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/1099-0496(200009)30:3%3C203::aid-ppul4%3E3.3.co;2-x" target="_blank" rel="noreferrer noopener">10.1002/1099-0496(200009)30:3%3C203::aid-ppul4%3E3.3.co;2-x</a>
Innervation of ectopic endometrium in a rat model of endometriosis
pain; neuronal responses; Science & Technology - Other Topics; gene-related peptide; female rats; stimulation; spinal-cord; neuropeptides; lung transplantation; afferent reinnervation; fertility; nerve-endings; transplant; uterus
Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain. Mechanisms that maintain the ectopic growths and evoke symptoms are poorly understood. One factor not yet considered is that the ectopic growths develop their own innervation. Here, we tested the hypothesis that the growths develop both an autonomic and a sensory innervation. We used a rat model of surgically induced ENDO whose growths mimic those in women. Furthermore, similar to women with ENDO, such rats exhibit reduced fertility and increased pelvic nociception. The ENDO was induced by autotransplanting, on mesenteric cascade arteries, small pieces of uterus that formed vascularized cysts. The cysts and healthy uterus were harvested from proestrous rats and immunostained using the pan-neuronal marker PGP9.5 and specific markers for calcitonin gene-related peptide (CGRP) (sensory C and AS fibers), substance P (SIP) (sensory C and AS fibers) and vesicular monoamine transporter (sympathetic fibers). Cysts (like the uterus) were robustly innervated, with many PGP9.5-stained neurites accompanying blood vessels and extending into nearby luminal epithelial layers. CGRP-, SP-, and vesicular monoamine transporter-immunostained neurites also were observed, with CGRP and SP neurites extending the furthest into the cyst lining. These results demonstrate that ectopic endometrial growths develop an autonomic and sensory innervation. This innervation could contribute not only to symptoms associated with ENDO but also to maintenance of the ectopic growths.
Berkley K J; Dmitrieva N; Curtis K S; Papka R E
Proceedings of the National Academy of Sciences of the United States of America
2004
2004-07
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1073/pnas.0403663101" target="_blank" rel="noreferrer noopener">10.1073/pnas.0403663101</a>
Immune response to CMV in solid organ transplant recipients: current concepts and future directions
adaptive immunity; antibody; cd4(+) t-cells; cell-mediated-immunity; CMV; human cytomegalovirus-infection; Immunology; innate immunity; kidney-transplantation; liver-transplantation; long-term; lung transplantation; preemptive therapy; receptor repertoire; recipient; renal-transplant; Toll-like receptor; transplantation; vaccine
Despite advances in immunosuppression and antiviral therapy, CMV continues to be a significant opportunistic pathogen adversely affecting the outcome of solid organ transplantation (SOT) recipients. While a significant proportion of CMV disease is caused by reactivation of latent virus, the risk is highest among CMV donor+ and recipient- SOT patients. CMV is responsible for both direct (e.g., pneumonitis, colitis) and indirect (e.g., rejection, atherosclerosis) morbidity and mortality. Healthy CMV-seropositive individuals have a high frequency of CMV-specific CD4(+) and CD8(+) T cells that provide immune protection by limiting CMV reactivation and replication. Changes to the innate and adaptive immune system from immunosuppressive therapy following SOT contribute to CMV disease pathogenesis. CMV disease after SOT is associated with poorer outcomes, thus novel strategies to prevent it are an area of active research. In this article, we review the current state of knowledge on the immune response to CMV following SOT.
Watkins R R; Lemonovich T L; Razonable R R
Expert Review of Clinical Immunology
2012
2012-05
Journal Article
<a href="http://doi.org/10.1586/eci.12.25" target="_blank" rel="noreferrer noopener">10.1586/eci.12.25</a>