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Text
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URL Address
<a href="http://doi.org/10.1046/j.1525-1438.2003.13317.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1525-1438.2003.13317.x</a>
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Pages
405-412
Issue
4
Volume
13
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Title
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Rodent models for ovarian cancer research
Publisher
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International Journal of Gynecological Cancer
Date
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2003
2003-07
Subject
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animal models; carcinoma cell-line; epithelial; gene-therapy; immunodeficient mice; luteinizing-hormone; lysophosphatidic acid; metastasis in-vivo; mouse models; neoplasms; nude-mice; Obstetrics & Gynecology; Oncology; ovarian-cancer; p53; review; tumor-associated antigens
Creator
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Stakleff K D S; Von Gruenigen V E
Description
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Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.
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<a href="http://doi.org/10.1046/j.1525-1438.2003.13317.x" target="_blank" rel="noreferrer noopener">10.1046/j.1525-1438.2003.13317.x</a>
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Journal Article
2003
Animal models
carcinoma cell-line
epithelial
gene-therapy
immunodeficient mice
International Journal of Gynecological Cancer
Journal Article
luteinizing-hormone
lysophosphatidic acid
metastasis in-vivo
mouse models
Neoplasms
nude-mice
Obstetrics & Gynecology
oncology
ovarian-cancer
p53
review
Stakleff K D S
tumor-associated antigens
von Gruenigen V E