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Text
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URL Address
<a href="http://doi.org/10.1097/00000372-199808000-00019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00000372-199808000-00019</a>
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Pages
422-424
Issue
4
Volume
20
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Title
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Syringocystadenoma papilliferum of the male breast
Publisher
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American Journal of Dermatopathology
Date
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1998
1998-08
Subject
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apocrine; Breast; Dermatology; differentiation; eccrine differentiation; GCDFP-15; lysozyme; male; plasma cell infiltrate; syringocystadenoma papilliferum; tumors
Creator
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Nowak M; Pathan A; Fatteh S; Lopez J
Description
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A 39-year-old man presented with a 2-cm, mildly tender mass in the right breast of many years' duration. Microscopic examination showed a syringocystadenoma papilliferum. Because of its location in the breast, we studied the lesion for immunohistochemical markers for apocrine differentiation. Gross cystic disease fluid protein-15 (GCDFP-15) staining yielded negative results in the cystic luminal epithelial cells, whereas GCDFP-15 and lysozyme staining yielded strongly positive results in the epithelial cells of adjacent tubular apocrine glands. Focal strong lysozyme positivity was seen in the cystic luminal epithelial cells. These findings do not support apocrine differentiation in this case, despite its location in the breast, an organ rich in specialized apocrine (lactiferous) elands. To our knowledge, this represents the first reported case of syringocystadenoma papilliferum of the male breast. We present the clinical and pathologic features of this unusual case and a review of the literature.
Identifier
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<a href="http://doi.org/10.1097/00000372-199808000-00019" target="_blank" rel="noreferrer noopener">10.1097/00000372-199808000-00019</a>
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Journal Article
1998
American Journal of Dermatopathology
apocrine
breast
Dermatology
differentiation
eccrine differentiation
Fatteh S
GCDFP-15
Journal Article
Lopez J
lysozyme
Male
Nowak M
Pathan A
plasma cell infiltrate
syringocystadenoma papilliferum
tumors