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40
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Text
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URL Address
<a href="http://doi.org/10.3389/fnana.2014.00017" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnana.2014.00017</a>
Pages
17–17
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Distribution of GABAergic cells in the inferior colliculus that project to the thalamus.
Publisher
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Frontiers in neuroanatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
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inhibition; auditory system; GAD; medial geniculate; tectothalamic
Creator
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Mellott Jeffrey G; Foster Nichole L; Nakamoto Kyle T; Motts Susan D; Schofield Brett R
Description
An account of the resource
A GABAergic component has been identified in the projection from the inferior colliculus (IC) to the medial geniculate body (MG) in cats and rats. We sought to determine if this GABAergic pathway exists in guinea pig, a species widely used in auditory research. The guinea pig IC contains GABAergic cells, but their relative abundance in the IC and their relative contributions to tectothalamic projections are unknown. We identified GABAergic cells with immunochemistry for glutamic acid decarboxylase (GAD) and determined that \textasciitilde21% of IC neurons are GABAergic. We then combined retrograde tracing with GAD immunohistochemistry to identify the GABAergic tectothalamic projection. Large injections of Fast Blue, red fluorescent beads or FluoroGold were deposited to include all subdivisions of the MG. The results demonstrate a GABAergic pathway from each IC subdivision to the ipsilateral MG. GABAergic cells constitute \textasciitilde22% of this ipsilateral pathway. In addition, each subdivision of the IC had a GABAergic projection to the contralateral MG. Measured by number of tectothalamic cells, the contralateral projection is about 10% of the size of the ipsilateral projection. GABAergic cells constitute about 20% of the contralateral projection. In summary, the results demonstrate a tectothalamic projection in guinea pigs that originates in part from GABAergic cells that project ipsilaterally or contralaterally to the MG. The results show similarities to both rats and cats, and carry implications for the role of GABAergic tectothalamic projections vis-a-vis the presence (in cats) or near absence (in rats and guinea pigs) of GABAergic interneurons in the MG.
Identifier
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<a href="http://doi.org/10.3389/fnana.2014.00017" target="_blank" rel="noreferrer noopener">10.3389/fnana.2014.00017</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Auditory system
Department of Anatomy & Neurobiology
Foster Nichole L
Frontiers in neuroanatomy
GAD
inhibition
medial geniculate
Mellott Jeffrey G
Motts Susan D
Nakamoto Kyle T
NEOMED College of Medicine
Schofield Brett R
tectothalamic
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fnana.2014.00124" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnana.2014.00124</a>
Pages
124–124
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus.
Publisher
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Frontiers in neuroanatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
GABA; auditory system; GAD; lemniscal; medial geniculate; non-lemniscal; tectothalamic
Creator
An entity primarily responsible for making the resource
Mellott Jeffrey G; Foster Nichole L; Ohl Andrew P; Schofield Brett R
Description
An account of the resource
Individual subdivisions of the medial geniculate body (MG) receive a majority of their ascending inputs from 1 or 2 subdivisions of the inferior colliculus (IC). This establishes parallel pathways that provide a model for understanding auditory projections from the IC through the MG and on to auditory cortex. A striking discovery about the tectothalamic circuit was identification of a substantial GABAergic component. Whether GABAergic projections match the parallel pathway organization has not been examined. We asked whether the parallel pathway concept is reflected in guinea pig tectothalamic pathways and to what degree GABAergic cells contribute to each pathway. We deposited retrograde tracers into individual MG subdivisions (ventral, MGv; medial, MGm; dorsal, MGd; suprageniculate, MGsg) to label tectothalamic cells and used immunochemistry to identify GABAergic cells. The MGv receives most of its IC input (\textasciitilde75%) from the IC central nucleus (ICc); MGd and MGsg receive most of their input (\textasciitilde70%) from IC dorsal cortex (ICd); and MGm receives substantial input from both ICc (\textasciitilde40%) and IC lateral cortex (\textasciitilde40%). Each MG subdivision receives additional input (up to 32%) from non-dominant IC subdivisions, suggesting cross-talk between the pathways. The proportion of GABAergic cells in each pathway depended on the MG subdivision. GABAergic cells formed \textasciitilde20% of IC inputs to MGv or MGm, \textasciitilde11% of inputs to MGd, and 4% of inputs to MGsg. Thus, non-GABAergic (i.e., glutamatergic) cells are most numerous in each pathway with GABAergic cells contributing to different extents. Despite smaller numbers of GABAergic cells, their distributions across IC subdivisions mimicked the parallel pathways. Projections outside the dominant pathways suggest opportunities for excitatory and inhibitory crosstalk. The results demonstrate parallel tectothalamic pathways in guinea pigs and suggest numerous opportunities for excitatory and inhibitory interactions within and between pathways.
Identifier
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<a href="http://doi.org/10.3389/fnana.2014.00124" target="_blank" rel="noreferrer noopener">10.3389/fnana.2014.00124</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Auditory system
Department of Anatomy & Neurobiology
Foster Nichole L
Frontiers in neuroanatomy
GABA
GAD
lemniscal
medial geniculate
Mellott Jeffrey G
NEOMED College of Medicine
non-lemniscal
Ohl Andrew P
Schofield Brett R
tectothalamic
-
Hyperlink
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URL
https://doi.org/10.1016/j.jchemneu.2022.102189
Dublin Core
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Title
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Neurotransmitter phenotype and axonal projection patterns of VIP-expressing neurons in the inferior colliculus
Creator
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Nichole L Beebe
Marina A Silveira
David Goyer
William A Noftz
Michael T Roberts
Brett R Schofield
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Description
An account of the resource
Neurons in the inferior colliculus (IC), the midbrain hub of the central auditory pathway, send ascending and descending projections to other auditory brain regions, as well as projections to other sensory and non-sensory brain regions. However, the axonal projection patterns of individual classes of IC neurons remain largely unknown. Vasoactive intestinal polypeptide (VIP) is a neuropeptide expressed by subsets of neurons in many brain regions. We recently identified a class of IC stellate neurons that we called VIP neurons because they are labeled by tdTomato (tdT) expression in VIP-IRES-Cre x Ai14 mice. Here, using fluorescence in situ hybridization, we found that tdT+ neurons in VIP-IRES-Cre x Ai14 mice express Vglut2, a marker of glutamatergic neurons, and VIP, suggesting that VIP neurons use both glutamatergic and VIPergic signaling to influence their postsynaptic targets. Next, using viral transfections with a Cre-dependent eGFP construct, we labeled the axonal projections of VIP neurons. As a group, VIP neurons project intrinsically, within the ipsilateral and contralateral IC, and extrinsically to all the major targets of the IC. Within the auditory system, VIP neurons sent axons and formed axonal boutons in higher centers, including the medial geniculate nucleus and the nucleus of the brachium of the IC. Less dense projections terminated in lower centers, including the nuclei of the lateral lemniscus, superior olivary complex, and dorsal cochlear nucleus. VIP neurons also project to several non-auditory brain regions, including the superior colliculus, periaqueductal gray, and cuneiform nucleus. The diversity of VIP projections compared to the homogeneity of VIP neuron intrinsic properties suggests that VIP neurons play a conserved role at the microcircuit level, likely involving neuromodulation through glutamatergic and VIPergic signaling, but support diverse functions at the systems level through their participation in different projection pathways.
Source
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J Chem Neuroanat
. 2022 Dec;126:102189. doi: 10.1016/j.jchemneu.2022.102189. Epub 2022 Nov 12.
Language
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English
2022
Defensive behavior
medial geniculate
modulation
Orienting
periaqueductal gray
Superior colliculus.