1
40
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Text
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URL Address
<a href="http://doi.org/10.3389/fnana.2014.00070" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnana.2014.00070</a>
Pages
70–70
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Subcollicular projections to the auditory thalamus and collateral projections to the inferior colliculus.
Publisher
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Frontiers in neuroanatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-7
Subject
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superior olive; medial geniculate nucleus; binaural; brain evolution; lateral lemniscus; paralemniscal area; parallel pathways; reticular formation
Creator
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Schofield Brett R; Mellott Jeffrey G; Motts Susan D
Description
An account of the resource
Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the inferior colliculus (IC) (Schofield et al., 2014). We conducted three experiments to characterize projections to the MG from the superior olivary and the lateral lemniscal regions in guinea pigs. For experiment 1, we made large injections of retrograde tracer into the MG. Labeled cells were most numerous in the superior paraolivary nucleus, ventral nucleus of the trapezoid body, lateral superior olivary nucleus, ventral nucleus of the lateral lemniscus, ventrolateral tegmental nucleus, paralemniscal region and sagulum. Additional sources include other periolivary nuclei and the medial superior olivary nucleus. The projections are bilateral with an ipsilateral dominance (66%). For experiment 2, we injected tracer into individual MG subdivisions. The results show that the subcollicular projections terminate primarily in the medial MG, with the dorsal MG a secondary target. The variety of projecting nuclei suggest a range of functions, including monaural and binaural aspects of hearing. These direct projections could provide the thalamus with some of the earliest (i.e., fastest) information regarding acoustic stimuli. For experiment 3, we made large injections of different retrograde tracers into one MG and the homolateral IC to identify cells that project to both targets. Such cells were numerous and distributed across many of the nuclei listed above, mostly ipsilateral to the injections. The prominence of the collateral projections suggests that the same information is delivered to both the IC and the MG, or perhaps that a common signal is being delivered as a preparatory indicator or temporal reference point. The results are discussed from functional and evolutionary perspectives.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fnana.2014.00070" target="_blank" rel="noreferrer noopener">10.3389/fnana.2014.00070</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
binaural
brain evolution
Department of Anatomy & Neurobiology
Frontiers in neuroanatomy
lateral lemniscus
medial geniculate nucleus
Mellott Jeffrey G
Motts Susan D
NEOMED College of Medicine
paralemniscal area
parallel pathways
reticular formation
Schofield Brett R
superior olive
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fnsys.2014.00188" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnsys.2014.00188</a>
Pages
188–188
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.
Publisher
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Frontiers in systems neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
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GABA; ascending; corticofugal; medial geniculate nucleus; modulation
Creator
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Mellott Jeffrey G; Bickford Martha E; Schofield Brett R
Description
An account of the resource
Descending projections from the auditory cortex (AC) terminate in subcortical auditory centers from the medial geniculate nucleus (MG) to the cochlear nucleus, allowing the AC to modulate the processing of acoustic information at many levels of the auditory system. The nucleus of the brachium of the inferior colliculus (NBIC) is a large midbrain auditory nucleus that is a target of these descending cortical projections. The NBIC is a source of several auditory projections, including an ascending projection to the MG. This ascending projection appears to originate from both excitatory and inhibitory NBIC cells, but whether the cortical projections contact either of these cell groups is unknown. In this study, we first combined retrograde tracing and immunochemistry for glutamic acid decarboxylase (GAD, a marker of GABAergic cells) to identify GABAergic and non-GABAergic NBIC projections to the MG. Our first result is that
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fnsys.2014.00188" target="_blank" rel="noreferrer noopener">10.3389/fnsys.2014.00188</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
ascending
Bickford Martha E
corticofugal
Department of Anatomy & Neurobiology
Frontiers in systems neuroscience
GABA
medial geniculate nucleus
Mellott Jeffrey G
modulation
NEOMED College of Medicine
Schofield Brett R