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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1152/ajpheart.00888.2020">http://doi.org/10.1152/ajpheart.00888.2020</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.
Creator
An entity primarily responsible for making the resource
Tan PPS; Hall D; Chilian WM; Chia YC; Mohd ZS; Lim HM; Kumar DN; Ching SM; Low TY; Noh MFM; Pung Y-F
Publisher
An entity responsible for making the resource available
American Journal Of Physiology. Heart And Circulatory Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-04-01
Description
An account of the resource
MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy.
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1152/ajpheart.00888.2020">http://doi.org/10.1152/ajpheart.00888.2020</a></td>
</tr></tbody></table>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2021
clinical biomarker
extracellular vesicles
high blood pressure
microvesicles
small non-coding RNA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00888.2020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00888.2020</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1522-1539 0363-6135
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1152/ajpheart.00888.2020" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1152/ajpheart.00888.2020</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
March 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.
Publisher
An entity responsible for making the resource available
American Journal Of Physiology. Heart And Circulatory Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-02-12
Subject
The topic of the resource
extracellular vesicles; small non-coding RNA; clinical biomarker; high blood pressure; microvesicles
Creator
An entity primarily responsible for making the resource
Tan PPS; Hall D; Chilian WM; Chia YC; Mohd ZS; Lim HM; Kumar DN; Ching SM; Low TY; Noh MFM; Pung Y-F
Description
An account of the resource
MicroRNAs (miRNAs) are small regulatory molecules that are involved in post-transcriptional modifications. These non-coding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potentials as non-invasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension; and the potentials of exosomal miRNAs as biomarkers in comparison to other free circulating miRNAs. Finally challenges and future research surrounding exosomal miRNAs will also be discussed. The information synthesized in this review summarizes current knowledge of non-invasive biomarkers for early hypertension diagnosis and for probing therapeutic efficacy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00888.2020" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00888.2020</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2021
American journal of physiology. Heart and circulatory physiology
Chia YC
Chilian WM
Ching SM
clinical biomarker
Department of Integrative Medical Sciences
extracellular vesicles
Hall D
high blood pressure
journalArticle
Kumar DN
Lim HM
Low TY
March 2021 List
microvesicles
Mohd ZS
NEOMED College of Medicine
Noh MFM
Pung Y-F
small non-coding RNA
Tan PPS