1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.freeradbiomed.2009.06.017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.freeradbiomed.2009.06.017</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 767-778 Issue 6 Volume 47 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress Publisher An entity responsible for making the resource available Free Radical Biology and Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2009 2009-09 Subject The topic of the resource Aldehyde dehydrogenase; Biochemistry & Molecular Biology; differential expression; dismutase; Endocrinology & Metabolism; Fasting; fatty-acid oxidation; glutathione-s-transferase; hepatic steatosis; Lipid peroxidation; Lipid peroxidation; liver; manganese-superoxide-dismutase; mitochondrial aldehyde dehydrogenase; nitric-oxide; Null mice; oxidative stress; PPAR-alpha; PPAR-alpha; Protein nitration; Protein oxidation; rat-liver; Steatosis; Superoxide Creator An entity primarily responsible for making the resource Abdelmegeed M A; Moon K H; Hardwick J P; Gonzalez F J; Song B J Description An account of the resource The peroxisome proliferator-activated receptor-alpha (PPAR alpha) regulates lipid homeostasis, particularly in the liver. This study was aimed at elucidating the relationship between hepatosteatosis and oxidative stress during fasting. Fasted Ppara-null mice exhibited marked hepatosteatosis, which was associated with elevated levels of lipid peroxidation, nitric oxide synthase activity, and hydrogen peroxide accumulation. Total glutathione (GSH), mitochondrial GSH, and the activities of major antioxidant enzymes were also lower in the fasted Ppara-null mice. Consequently, the number and extent of nitrated proteins were markedly increased in the fasted Ppara-null mice, although high levels of protein nitration were still detected in the fed Ppara-null mice while many oxidatively modified proteins were only found in the fasted Ppara-null mice. However, the role of inflammation in increased oxidative stress in the fasted Ppara-null mice was minimal based on the similar levels of tumor necrosis factor-alpha change in all groups. These results with increased oxidative stress observed in the fasted Ppara-null mice compared with other groups demonstrate a role for PPAR alpha in fasting-mediated oxidative stress and that inhibition of PPAR alpha functions may increase the susceptibility to oxidative damage in the presence of another toxic agent. Published by Elsevier Inc. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.freeradbiomed.2009.06.017" target="_blank" rel="noreferrer noopener">10.1016/j.freeradbiomed.2009.06.017</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 2009 Abdelmegeed M A Aldehyde Dehydrogenase Biochemistry & Molecular Biology differential expression dismutase Endocrinology & Metabolism Fasting fatty-acid oxidation Free Radical Biology and Medicine glutathione-s-transferase Gonzalez F J Hardwick J P hepatic steatosis Journal Article or Conference Abstract Publication Lipid Peroxidation Liver manganese-superoxide-dismutase mitochondrial aldehyde dehydrogenase Moon K H nitric-oxide Null mice Oxidative Stress PPAR-alpha Protein nitration Protein oxidation rat-liver Song B J Steatosis superoxide