1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M039347</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2754-2762
Issue
10
Volume
54
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
apolipoprotein-b secretion; Biochemistry & Molecular Biology; cells; diabetes; extracellular signal-regulated kinase; fatty liver; function; induced insulin-resistance; ldl; lipid metabolism; liver; mitogen-activated protein kinase; obesity; overproduction; oxidative stress; ubiquitination; vascular; vldl production
Creator
An entity primarily responsible for making the resource
Bi L P; Chiang J Y L; Ding W X; Dunn W; Roberts B; Li T G
Description
An account of the resource
Hepatic VLDL overproduction is a characteristic feature of diabetes and an important contributor to diabetic dyslipidemia. Hepatic sortilin 1 (Sort1), a cellular trafficking receptor, is a novel regulator of plasma lipid metabolism and reduces plasma cholesterol and triglycerides by inhibiting hepatic apolipoprotein B production. Elevated circulating free fatty acids play key roles in hepatic VLDL overproduction and the development of dyslipidemia. This study investigated the regulation of hepatic Sort1 in obesity and diabetes and the potential implications in diabetic dyslipidemia. Results showed that hepatic Sort1 protein was markedly decreased in mouse models of type I and type II diabetes and in human individuals with obesity and liver steatosis, whereas increasing hepatic Sort1 expression reduced plasma cholesterol and triglycerides in mice. Mechanistic studies showed that the saturated fatty acid palmitate activated extracellular signal-regulated kinase (ERK) and inhibited Sort1 protein by mechanisms involving Sort1 protein ubiquitination and degradation. Consistently, hepatic ERK signaling was activated in diabetic mice, whereas blocking ERK signaling by an ERK inhibitor increased hepatic Sort1 protein in mice. These results suggest that increased saturated fatty acids downregulate liver Sort1 protein, which may contribute to the development of dyslipidemia in obesity and diabetes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">10.1194/jlr.M039347</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
apolipoprotein-b secretion
Bi L P
Biochemistry & Molecular Biology
Cells
Chiang J Y L
Diabetes
Ding W X
Dunn W
extracellular signal-regulated kinase
Fatty Liver
Function
induced insulin-resistance
Journal Article or Conference Abstract Publication
Journal of lipid research
LDL
Li T G
Lipid Metabolism
Liver
mitogen-activated protein kinase
Obesity
overproduction
Oxidative Stress
Roberts B
ubiquitination
Vascular
vldl production
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M039347</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2754-2762
Issue
10
Volume
54
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
apolipoprotein-b secretion; Biochemistry & Molecular Biology; cells; diabetes; extracellular signal-regulated kinase; fatty liver; function; induced insulin-resistance; ldl; lipid metabolism; liver; mitogen-activated protein kinase; Obesity; overproduction; oxidative stress; ubiquitination; vascular; vldl production
Creator
An entity primarily responsible for making the resource
Bi L P; Chiang J Y L; Ding W X; Dunn W; Roberts B; Li T G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">10.1194/jlr.M039347</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
apolipoprotein-b secretion
Bi L P
Biochemistry & Molecular Biology
Cells
Chiang J Y L
Diabetes
Ding W X
Dunn W
extracellular signal-regulated kinase
Fatty Liver
Function
induced insulin-resistance
Journal of lipid research
LDL
Li T G
Lipid Metabolism
Liver
mitogen-activated protein kinase
Obesity
overproduction
Oxidative Stress
Roberts B
ubiquitination
Vascular
vldl production
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00421.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00421.2002</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
H176-H184
Issue
1
Volume
284
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Heart and Circulatory Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-01
Subject
The topic of the resource
angiotensin-ii; Cardiovascular System & Cardiology; differentiation; fibrosis; gene-expression; Heart failure; identification; induction; Kirsten Ras; mineralocorticoid; mitogen-activated protein kinase; myofibroblast; na+ reabsorption; Physiology; receptor; spironolactone; transcription
Creator
An entity primarily responsible for making the resource
Stockand J D; Meszaros J G
Description
An account of the resource
Aldosterone plays a pathological role in cardiac fibrosis by directly affecting cardiac fibroblasts. Understanding of the cellular mechanisms of aldosterone action in cardiac fibroblasts, however, is rudimentary. One possibility is that aldosterone promotes proliferation of cardiac fibroblasts by activating specific cellular signaling cascades. The current study tests whether aldosterone stimulates proliferation of isolated adult rat cardiac myofibroblasts (RCF) by activating Kirsten Ras (Ki-RasA) and its effector, the MAPK1/2 cascade. Aldosterone (10 nM) significantly increased RCF proliferation. This action was sensitive to the mineralocorticoid receptor (MR) antagonist spironolactone. Expression of MR in RCF and the whole rat heart was confirmed by immunoblotting. Aldosterone significantly increased absolute and active (GTP bound) Ki-RasA levels in RCF. Aldosterone, in addition, significantly increased phospho-c-Raf and phospho-MAPK1/2. The effects of aldosterone on Ki-RasA and phospho-c-Raf proteins were inhibited by spironolactone but not RU-486, suggesting that aldosterone acts via MR. Inhibitors of MEK1/2 and c-Raf prevented aldosterone-induced activation of MAPK1/2 and proliferation. These results show that aldosterone directly increases RCF proliferation through MR-dependent activation of Ki-RasA and its effector, the MAPK1/2 cascade. Activation of cardiac fibroblasts through such a cascade may play a role in the pathological actions exerted by aldosterone on the heart.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00421.2002" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00421.2002</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
American Journal of Physiology-Heart and Circulatory Physiology
angiotensin-ii
Cardiovascular System & Cardiology
differentiation
Fibrosis
gene-expression
Heart failure
identification
induction
Journal Article
Kirsten Ras
Meszaros J G
mineralocorticoid
mitogen-activated protein kinase
myofibroblast
na+ reabsorption
Physiology
Receptor
spironolactone
Stockand J D
Transcription