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Text
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URL Address
<a href="http://doi.org/10.1016/s0006-8993(98)00034-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(98)00034-1</a>
Pages
299–302
Issue
1
Volume
791
Dublin Core
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Title
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The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.
Publisher
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Brain research
Date
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1998
1998-04
Subject
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Aging/*metabolism; Ala(2)-MePhe(4)-Gly(5)-; Animals; delta/antagonists & inhibitors/*metabolism; Enkephalin; Enkephalins/metabolism; Inbred F344; Male; mu/agonists/*metabolism; Naltrexone/analogs & derivatives/metabolism; Narcotic Antagonists/metabolism; Opioid; Radioligand Assay; Rats; Receptors; Spinal Cord/*metabolism
Creator
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Hoskins D L; Gordon T L; Crisp T
Description
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Previous research has demonstrated that the antinociceptive efficacy of opioids decreases with advancing age. This study utilized radioligand binding techniques to determine if this decline is due to a change in the receptor density (Bmax) and/or affinity (measured as Kd) of the mu (mu) and/or delta (delta) opioid receptors in the spinal cord with advancing age. Saturation binding analysis with [3H][d-Ala2,N-methyl-Phe4,Gly5-ol]enkephalin (DAMGO: a mu-opioid selective agonist) and [3H]naltrindole (a delta-opioid selective antagonist) revealed no age-related changes in Bmax for either the mu or delta-opioid receptors. The Kd value for naltrindole was likewise unaffected by age. The Kd value for DAMGO however, was significantly higher in the aged group as compared with the young and mature groups, indicating a decreased affinity of spinal mu-opioid receptors for DAMGO.
Identifier
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<a href="http://doi.org/10.1016/s0006-8993(98)00034-1" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(98)00034-1</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Aging/*metabolism
Ala(2)-MePhe(4)-Gly(5)-
Animals
Brain research
Crisp T
delta/antagonists & inhibitors/*metabolism
Enkephalin
Enkephalins/metabolism
Gordon T L
Hoskins D L
Inbred F344
Male
mu/agonists/*metabolism
Naltrexone/analogs & derivatives/metabolism
Narcotic Antagonists/metabolism
Opioid
Radioligand Assay
Rats
Receptors
Spinal Cord/*metabolism