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A Novel TRPV4-dependent Mechanotranscription Pathway Regulates Cardiac Fibrosis Following Pressure-Overload

Tags: 2015, Adapala R K, Cappelli H, cardiac fibroblast, Cardiovascular System & Cardiology, Chilian W M, Circulation research, Fibrosis, Hematology, Journal Article or Conference Abstract Publication, Luli J, mechanical signaling, Meszaros J G, myofibroblast, Ohanyan V A, Paruchuri S, Thodeti C, Thoppil R, TRPV4

Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts.

Diabetes is an independent risk factor for cardiovascular disease that can eventually cause cardiomyopathy and heart failure. Cardiac fibroblasts (CF) are the critical mediators of physiological and pathological cardiac remodeling; however, the…

Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling

Aldosterone plays a pathological role in cardiac fibrosis by directly affecting cardiac fibroblasts. Understanding of the cellular mechanisms of aldosterone action in cardiac fibroblasts, however, is rudimentary. One possibility is that aldosterone…

A TRP to cardiac fibroblast differentiation.

The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying this process is not well known. Calcium signaling plays an important role in the regulation…

Browse Items (4 total)

A Novel TRPV4-dependent Mechanotranscription Pathway Regulates Cardiac Fibrosis Following Pressure-Overload

Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts.

Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling

A TRP to cardiac fibroblast differentiation.