1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2009.12.079" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2009.12.079</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
870-877
Issue
3
Volume
20
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Predictive Screening Model For Potential Vector-mediated Transport Of Cationic Substrates At The Blood-brain Barrier Choline Transporter
Publisher
An entity responsible for making the resource available
Bioorganic & Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-02
Subject
The topic of the resource
12-diyl-bis-3-picolinium dibromide; analogs; Carrier-mediated transport; central-nervous-system; Chemistry; Drug bioavailability; Drug screening; evoked dopamine; extracellular dopamine; high-affinity choline; molecular-field analysis; n; n'-dodecane-1; Nicotinic receptor antagonists; Nicotinic receptor antagonists; perfusion technique; Pharmacology & Pharmacy; Quaternary ammonium; quaternary ammonium analogs; rat; release; Smoking cessation; striatal synaptosomes
Creator
An entity primarily responsible for making the resource
Geldenhuys W J; Manda V K; Mittapalli R K; Van der Schyf C J; Crooks P A; Dwoskin L P; Allen D D; Lockman P R
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2009.12.079" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2009.12.079</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
12-diyl-bis-3-picolinium dibromide
2010
Allen D D
analogs
Bioorganic & medicinal chemistry letters
carrier-mediated transport
central-nervous-system
Chemistry
Crooks P A
Drug bioavailability
Drug screening
Dwoskin L P
evoked dopamine
extracellular dopamine
Geldenhuys W J
high-affinity choline
Lockman P R
Manda V K
Mittapalli R K
molecular-field analysis
n
n'-dodecane-1
nicotinic receptor antagonists
perfusion technique
Pharmacology & Pharmacy
quaternary ammonium
quaternary ammonium analogs
rat
release
Smoking Cessation
striatal synaptosomes
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2008.08.099" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2008.08.099</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
5622-5625
Issue
20
Volume
18
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
bis-pyridinium cyclophanes: Novel ligands with high affinity for the blood-brain barrier choline transporter
Publisher
An entity responsible for making the resource available
Bioorganic & Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
12-diyl-bis-3-picolinium dibromide; acetylcholine receptor; ammonium-salts; blood-brain barrier choline transporter; carrier-mediated transport; Chemistry; drug delivery; evoked dopamine release; extracellular dopamine; hyperactivity; inhibition; n; n-alkylnicotinium analogs; n'-dodecane-1; nicotinic; nicotinic receptor antagonists; Pharmacology & Pharmacy; quaternary; quaternary ammonium
Creator
An entity primarily responsible for making the resource
Zhang Z F; Lockman P R; Mittapalli R K; Allen D D; Dwoskin L P; Crooks P A
Description
An account of the resource
A series of bis-pyridinium cyclophane analogs designed as conformationally restricted bis-quaternary ammonium compounds were evaluated for their affinity for the blood-brain barrier (BBB) choline transporter. All the cyclophanes investigated exhibited high affinity compared to choline. Of these compounds, N, N'-(1,10-decanediyl)3,3'-(1,9-decadiyn-1,10-diyl)-bis-pyridinium diiodide (5c) and N, N'-(1,9-nonanediyl) 3,3'-(1,9-decadiyn-1,10-diyl)-bis-pyridinium dibromide (5b) exhibited highest affinity with K(i) values of 0.8 mu M and 1.4 mu M, respectively, and constitute some of the most potent BBB choline transporter ligands reported. (C) 2008 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2008.08.099" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2008.08.099</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
12-diyl-bis-3-picolinium dibromide
2008
acetylcholine receptor
Allen D D
ammonium-salts
Bioorganic & medicinal chemistry letters
blood-brain barrier choline transporter
carrier-mediated transport
Chemistry
Crooks P A
Drug delivery
Dwoskin L P
evoked dopamine release
extracellular dopamine
hyperactivity
inhibition
Journal Article
Lockman P R
Mittapalli R K
n
n-alkylnicotinium analogs
n'-dodecane-1
nicotinic
nicotinic receptor antagonists
Pharmacology & Pharmacy
quaternary
quaternary ammonium
Zhang Z F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2010.04.098" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2010.04.098</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3208-3210
Issue
11
Volume
20
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter
Publisher
An entity responsible for making the resource available
Bioorganic & Medicinal Chemistry Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
12-diyl-bis-3-picolinium dibromide; analogs; Bis-quaternary ammonium salts; Blood-brain barrier; Chemistry; Choline transporter; evoked dopamine release; extracellular dopamine; hyperactivity; mediated transport; n; n'-dodecane-1; nicotinic-receptor antagonist; nucleus-accumbens; Pharmacology & Pharmacy; rat; tobacco dependence; vector
Creator
An entity primarily responsible for making the resource
Zheng G R; Zhang Z F; Lockman P R; Geldenhuys W J; Allen D D; Dwoskin L P; Crooks P A
Description
An account of the resource
A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT. (C) 2010 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2010.04.098" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2010.04.098</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
12-diyl-bis-3-picolinium dibromide
2010
Allen D D
analogs
Bioorganic & medicinal chemistry letters
Bis-quaternary ammonium salts
Blood-brain barrier
Chemistry
Choline transporter
Crooks P A
Dwoskin L P
evoked dopamine release
extracellular dopamine
Geldenhuys W J
hyperactivity
Journal Article
Lockman P R
mediated transport
n
n'-dodecane-1
nicotinic-receptor antagonist
nucleus-accumbens
Pharmacology & Pharmacy
rat
tobacco dependence
vector
Zhang Z F
Zheng G R