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Text
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URL Address
<a href="http://doi.org/10.1152/japplphysiol.01201.2001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/japplphysiol.01201.2001</a>
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Pages
2207-2213
Issue
6
Volume
93
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Title
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Lung edema clearance: 20 years of progress - Invited review: Alveolar edema fluid clearance in the injured lung
Publisher
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Journal of Applied Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
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therapy; liquid clearance; Physiology; pulmonary-edema; Sport Sciences; sodium transport; agonist; epithelial; active sodium-transport; alveolar fluid clearance; barrier function; agonists; respiratory-distress syndrome; na-k-atpase; adenovirus-mediated transfer; beta-adrenergic; beta(1) subunit gene; lung injury; rat lungs
Creator
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Berthiaume Y; Folkesson H G; Matthay M A
Description
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Resolution of pulmonary edema involved active transepithelial sodium transport. Although several of the cellular and molecular mechanisms involved are relatively well understood, it is only recently that the regulation of these mechanisms in injured lung are being evaluated. Interestingly, in mild-to-moderate lung injury, alveolar edema fluid clearance is often preserved. This preserved or enhanced alveolar fluid clearance is mediated by catecholamine-dependent or -independent mechanisms. This stimulation of alveolar liquid clearance is related to activation or increased expression of sodium transport molecules such as the epithelial sodium channel or the Na+-K+-ATPase pump and may also involve the cystic fibrosis transmembrane conductance regulator. When severe lung injury occurs, the decrease in alveolar liquid clearance may be related to changes in alveolar permeability or to changes in activity or expression of sodium or chloride transport molecules. Multiple pharmacological tools such as beta-adrenergic agonists, vasoactive drugs, or gene therapy may prove effective in stimulating the resolution of alveolar edema in the injured lung.
Identifier
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<a href="http://doi.org/10.1152/japplphysiol.01201.2001" target="_blank" rel="noreferrer noopener">10.1152/japplphysiol.01201.2001</a>
Format
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Journal Article or Conference Abstract Publication
2002
active sodium-transport
adenovirus-mediated transfer
agonist
agonists
alveolar fluid clearance
barrier function
Berthiaume Y
beta-adrenergic
beta(1) subunit gene
epithelial
Folkesson H G
Journal Article or Conference Abstract Publication
Journal of Applied Physiology
liquid clearance
Lung Injury
Matthay M A
na-k-atpase
Physiology
pulmonary-edema
rat lungs
respiratory-distress syndrome
sodium transport
Sport Sciences
therapy