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Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7 alpha-hydroxylase gene

Bile acids activate a nuclear receptor, farnesoid X receptor (FXR), that induces bile salt export pump (BSEP) but inhibits cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription in the liver. Guggulsterone, a plant sterol that lowers serum…

Tags: 2003, acid receptor, bile acid, bile-acid synthesis, Biochemical and biophysical research communications, Biochemistry & Molecular Biology, Biophysics, Chiang J Y L, cholesterol metabolism, feedback-regulation, FXR, Journal Article, Liver, natural product, Nuclear Receptor, Nuclear Receptors, Owsley E, Pregnane X Receptor, transport

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