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<a href="http://doi.org/10.7554/eLife.43770" target="_blank" rel="noreferrer noopener">http://doi.org/10.7554/eLife.43770</a>
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8
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Title
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A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice
Publisher
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eLife
Date
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2019
2019-04
Subject
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auditory; Inferior colliculus; mouse; neural circuits; neuron types; neuroscience; optogenetics; VIP
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Goyer David; Silveira Marina A; George Alexander P; Beebe Nichole L; Edelbrock Ryan M; Malinski Peter T; Schofield Brett R; Roberts Michael T
Description
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Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC microcircuitry remains largely unknown. Using a multifaceted approach in mice, we have identified vasoactive intestinal peptide (VIP) neurons as a novel class of IC principal neurons. VIP neurons are glutamatergic stellate cells with sustained firing patterns. Their extensive axons project to long-range targets including the auditory thalamus, auditory brainstem, superior colliculus, and periaqueductal gray. Using optogenetic circuit mapping, we found that VIP neurons integrate input from the contralateral IC and the dorsal cochlear nucleus. The dorsal cochlear nucleus also drove feedforward inhibition to VIP neurons, indicating that inhibitory circuits within the IC shape the temporal integration of ascending inputs. Thus, VIP neurons are well-positioned to influence auditory computations in a number of brain regions.
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<a href="http://doi.org/10.7554/eLife.43770" target="_blank" rel="noreferrer noopener">10.7554/eLife.43770</a>
2019
Auditory
Beebe Nichole L
Department of Anatomy & Neurobiology
Edelbrock Ryan M
eLife
George Alexander P
Goyer David
inferior colliculus
June 2019 Update
Malinski Peter T
mouse
NEOMED College of Medicine
neural circuits
neuron types
Neuroscience
optogenetics
Roberts Michael T
Schofield Brett R
Silveira Marina A
VIP