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Text
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URL Address
<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.biopsych.2004.06.023</a>
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Pages
301-307
Issue
5
Volume
56
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Title
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Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria
Publisher
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Biological Psychiatry
Date
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2004
2004-09
Subject
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cognition; cognitive assessment; cognitive enhancement; impairment; memory; neural basis; neurocognition; neurocognitive deficits; neuroleptic-naive; neuropsychological function; Neurosciences & Neurology; performance; Psychiatry; psychopharmacology; risperidone; schizophrenia; siblings; thought-disorder
Creator
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Green M F; Nuechterlein K H; Gold J M; Barch D M; Cohen J; Essock S; Fenton W S; Frese F; Goldberg T E; Heaton R K; Keefe R S E; Kern R S; Kraemer H; Stover E; Weinberger D R; Zalcman S; Marder S R
Description
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To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) establisbed the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference . The goals of the meeting were to 1) the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria, for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literatum and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory. Reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizopbrenia.
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<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">10.1016/j.biopsych.2004.06.023</a>
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Journal Article or Conference Abstract Publication
2004
Barch D M
Biological psychiatry
Cognition
cognitive assessment
cognitive enhancement
Cohen J
Essock S
Fenton W S
Frese F
Gold J M
Goldberg T E
Green M F
Heaton R K
impairment
Journal Article or Conference Abstract Publication
Keefe R S E
Kern R S
Kraemer H
Marder S R
Memory
neural basis
neurocognition
neurocognitive deficits
neuroleptic-naive
neuropsychological function
Neurosciences & Neurology
Nuechterlein K H
Performance
Psychiatry
Psychopharmacology
risperidone
Schizophrenia
siblings
Stover E
thought-disorder
Weinberger D R
Zalcman S