1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/jm070577s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/jm070577s</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
6501-6506
Issue
26
Volume
50
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conformational comparisons of a series of tachykinin peptide analogs
Publisher
An entity responsible for making the resource available
Journal of Medicinal Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-12
Subject
The topic of the resource
Pharmacology & Pharmacy; escherichia-coli; nmr; dynamics; nuclear-magnetic-resonance; substance-p receptor; agonists; neuropeptides; bradykinin; molecular modeling investigations; sds micelles
Creator
An entity primarily responsible for making the resource
Beard D J; Perrine S A; Phillips E; Hoque S; Conerly S; Tichenor C; Simmons M A; Young J K
Description
An account of the resource
Previous studies have shown differences in the biological activity and the structure of two naturally occurring tachykinin peptides, substance P (SP, RPKPQQFFGLM-NH2),and ranatachykinin C (RTKC, HNPASFIGLM-NH2). To further understand the basis for these differences, four analogs that selectively incorporate the amino acid differences between SP and RTKC have been synthesized for study. The four peptide analogs studied have the following amino acid sequences: SP2-11, also known as des-Arg SP (PKPQQFFGLM-NH2); Q5A-SP (RPKPAQFFGLM-NH2); Q6S-SP (RPKPQSFFGLM-NH2); and Q5AQ6S-SP (RPKPASFFGLM-NH2). Nuclear magnetic resonance spectroscopy and molecular modeling calculations were performed on SP, RTKC, SP2-11, Q5A-SP, Q6S-SP, and Q5AQ6S-SP to compare their conformational differences and similarities in the presence of the membrane mimetic system sodium dodecyl sulfate. The molecular modeling data of the analogs Q5A-SP and Q6S-SP show residues 1-3 have a random conformation and residues 4-8 have a helical structure, while the C-terminus contains a poly C-7 conformation that is similar to SP but different from RTKC., The molecular modeling data of the analogs SP2-11 and Q5AQ6S-SP show a continuous helix conformation for residues 4-11 at the C-terminus, which is different from SP but similar to RTKC. These structural differences are related to the functional differences of binding of the peptides at the SP receptor (NK1).
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/jm070577s" target="_blank" rel="noreferrer noopener">10.1021/jm070577s</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
agonists
Beard D J
bradykinin
Conerly S
dynamics
escherichia-coli
Hoque S
Journal Article or Conference Abstract Publication
Journal of medicinal chemistry
molecular modeling investigations
neuropeptides
nmr
nuclear-magnetic-resonance
Perrine S A
Pharmacology & Pharmacy
Phillips E
sds micelles
Simmons M A
substance-p receptor
Tichenor C
Young J K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1073/pnas.0403663101" target="_blank" rel="noreferrer noopener">http://doi.org/10.1073/pnas.0403663101</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11094-11098
Issue
30
Volume
101
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Innervation of ectopic endometrium in a rat model of endometriosis
Publisher
An entity responsible for making the resource available
Proceedings of the National Academy of Sciences of the United States of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-07
Subject
The topic of the resource
pain; neuronal responses; Science & Technology - Other Topics; gene-related peptide; female rats; stimulation; spinal-cord; neuropeptides; lung transplantation; afferent reinnervation; fertility; nerve-endings; transplant; uterus
Creator
An entity primarily responsible for making the resource
Berkley K J; Dmitrieva N; Curtis K S; Papka R E
Description
An account of the resource
Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain. Mechanisms that maintain the ectopic growths and evoke symptoms are poorly understood. One factor not yet considered is that the ectopic growths develop their own innervation. Here, we tested the hypothesis that the growths develop both an autonomic and a sensory innervation. We used a rat model of surgically induced ENDO whose growths mimic those in women. Furthermore, similar to women with ENDO, such rats exhibit reduced fertility and increased pelvic nociception. The ENDO was induced by autotransplanting, on mesenteric cascade arteries, small pieces of uterus that formed vascularized cysts. The cysts and healthy uterus were harvested from proestrous rats and immunostained using the pan-neuronal marker PGP9.5 and specific markers for calcitonin gene-related peptide (CGRP) (sensory C and AS fibers), substance P (SIP) (sensory C and AS fibers) and vesicular monoamine transporter (sympathetic fibers). Cysts (like the uterus) were robustly innervated, with many PGP9.5-stained neurites accompanying blood vessels and extending into nearby luminal epithelial layers. CGRP-, SP-, and vesicular monoamine transporter-immunostained neurites also were observed, with CGRP and SP neurites extending the furthest into the cyst lining. These results demonstrate that ectopic endometrial growths develop an autonomic and sensory innervation. This innervation could contribute not only to symptoms associated with ENDO but also to maintenance of the ectopic growths.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1073/pnas.0403663101" target="_blank" rel="noreferrer noopener">10.1073/pnas.0403663101</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
afferent reinnervation
Berkley K J
Curtis K S
Dmitrieva N
female rats
Fertility
gene-related peptide
Journal Article or Conference Abstract Publication
lung transplantation
nerve-endings
neuronal responses
neuropeptides
Pain
Papka R E
Proceedings of the National Academy of Sciences of the United States of America
Science & Technology - Other Topics
spinal-cord
Stimulation
transplant
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0165-1838(96)00091-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0165-1838(96)00091-4</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
257-263
Issue
3
Volume
61
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of inotropic and chronotropic effects of vasoactive intestinal peptide in isolated dog atria
Publisher
An entity responsible for making the resource available
Journal of the Autonomic Nervous System
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
adenylate-cyclase; anesthetized dogs; atrium; autonomic nervous system; cardiac; conscious dogs; contractile force; heart rate; heart rate; isoproterenol; neuropeptide; neuropeptides; Neurosciences & Neurology; parasympathetic; performance; polypeptide; receptor; receptors; Substance P; vip
Creator
An entity primarily responsible for making the resource
Wallick D W; Stuesse S L
Description
An account of the resource
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation, Atria were removed, maintained in a bath, and perfused with Tyrode's solution. Contractile force and atrial depolarization were measured, VIP (18.8-600 pmol) was injected into a cannulated sinoatrial nodal artery and dose response curves were obtained. The mean EC(50) was similar for the inotropic and the chronotropic responses (136 and 144 pmol, respectively). Time courses of the onset and of recovery from the responses were measured. Times for onset of VIP effects were similar but, once the effect was initiated, rate of development of the response and recovery time from the responses were dose dependent, The increases in atrial rate lasted two to four times longer than did the increases in contractile force. Recovery from the chronotropic and inotropic responses to VIP differ, suggesting that the intracellular responses are coupled differently to the receptors. The responses to VIP were compared to those of 100 pmol isoproterenol, another positive chronotropic and inotropic agent. Isoproterenol was a slightly more potent chronotropic and inotropic agent than VIP. Desensitization of the responses was determined. Repeated exposures to VIP decreased the chronotropic response but not the inotropic response to VIP. There was no significant decrease in responsiveness to isoproterenol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-1838(96)00091-4" target="_blank" rel="noreferrer noopener">10.1016/s0165-1838(96)00091-4</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1996
adenylate-cyclase
anesthetized dogs
atrium
autonomic nervous system
Cardiac
conscious dogs
contractile force
Heart Rate
isoproterenol
Journal Article
Journal of the Autonomic Nervous System
neuropeptide
neuropeptides
Neurosciences & Neurology
parasympathetic
Performance
polypeptide
Receptor
Receptors
Stuesse S L
SUBSTANCE P
VIP
Wallick D W