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Text
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URL Address
<a href="http://doi.org/10.1016/0896-6273(92)90067-n" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0896-6273(92)90067-n</a>
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Pages
1081-1088
Issue
6
Volume
9
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Title
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NEUROTROPHIN EXPRESSION IN RAT HIPPOCAMPAL SLICES - A STIMULUS PARADIGM INDUCING LTP IN CA1 EVOKES INCREASES IN BDNF AND NT-3 MESSENGER-RNAS
Publisher
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Neuron
Date
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1992
1992-12
Subject
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alzheimers-disease; choline-acetyltransferase activity; dopamine-beta-hydroxylase; factor family; nerve growth-factor; neuronal death; Neurosciences & Neurology; ngf; protein-kinase; receptor; selective induction; tyrosine-hydroxylase
Creator
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Patterson S L; Grover L M; Schwartzkroin P A; Bothwell M
Description
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We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons. No changes in BDNF or NT-3 mRNA levels were seen in the nonstimulated regions of the pyramidal cell layer or the dentate. No change was seen in the levels of NGF mRNA at the time point examined. These results suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus. Given that known effects of NGF (and presumably of BDNF and NT-3) include elevation of neurotransmitter levels, elevation of sodium channels, and promotion of axonal terminal sprouting, activity-associated changes in neurotrophin levels may play a role in regulating neural connections in the adult as well as the developing nervous system.
Identifier
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<a href="http://doi.org/10.1016/0896-6273(92)90067-n" target="_blank" rel="noreferrer noopener">10.1016/0896-6273(92)90067-n</a>
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Journal Article
1992
alzheimers-disease
Bothwell M
choline-acetyltransferase activity
dopamine-beta-hydroxylase
factor family
Grover L M
Journal Article
nerve growth-factor
Neuron
neuronal death
Neurosciences & Neurology
ngf
Patterson S L
protein-kinase
Receptor
Schwartzkroin P A
selective induction
tyrosine-hydroxylase