1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(01)03113-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(01)03113-4</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
160-164
Issue
1
Volume
921
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-12
Subject
The topic of the resource
brain; catecholamine; dopaminergic activity; exercise; fatigue; left ventricle; mechanisms; metabolism; Neurosciences & Neurology; nigrostriatal; performance; physical exercise; rats; responses; serotonin
Creator
An entity primarily responsible for making the resource
Kalinski M I; Dluzen D E; Stadulis R
Description
An account of the resource
Treatment with methamphetamine (MA - 20 mg/kgx4 i.p. at 2-h intervals) or its vehicle at 7 days prior to tests of running time to exhaustion were evaluated in 60-day-old CD-1 male mice. Pre-treatment running times were not significantly different between the two groups. MA resulted in significantly decreased running times to exhaustion compared to vehicle-treated controls and a significant reduction in corpus striatal dopamine and DOPAC but not norepinephrine. No statistically significant differences in catecholamines were obtained within the hypothalamus, or left ventricle of the heart, nor were body weights significantly different between these groups. The data show that a regimen of MA, which results in an approximate 90% depletion of striatal DA. produces a reduction in running time to exhaustion. (C) 2001 Elsevier Science B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(01)03113-4" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(01)03113-4</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2001
Brain
Brain research
catecholamine
Dluzen D E
dopaminergic activity
Exercise
fatigue
Journal Article or Conference Abstract Publication
Kalinski M I
left ventricle
mechanisms
Metabolism
Neurosciences & Neurology
nigrostriatal
Performance
physical exercise
Rats
responses
serotonin
Stadulis R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
140-150
Volume
1139
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex Differences In Dopamine- And Vesicular Monoamine-transporter Functions Implications For Methamphetamine Use And Neurotoxicity
Publisher
An entity responsible for making the resource available
Drug Addiction: Research Frontiers and Treatment Advances
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008
Subject
The topic of the resource
abuse; addiction; cd-1 mice; dopaminergic; drug abuse; estrogen; estrous-cycle; evoked striatal dopamine; female; gender-differences; gender-differences; inhibition; nigrostriatal; output; rats; sites; toxicity; uptake
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2008
abuse
Addiction
cd-1 mice
Dluzen D E
dopaminergic
Drug abuse
Drug Addiction: Research Frontiers and Treatment Advances
estrogen
estrous-cycle
evoked striatal dopamine
Female
gender-differences
inhibition
McDermott J L
nigrostriatal
output
Rats
sites
toxicity
uptake
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
282-294
Volume
1074
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, Testosterone, And Methamphetamine Toxicity
Publisher
An entity responsible for making the resource available
Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, Ghb, and Substituted Amphetamines
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006
Subject
The topic of the resource
17-beta-estradiol; c57/b1 mice; differences; female; gonadal steroids; inhibition; mptp-induced neurotoxicity; neurodegeneration; neuroprotection; neurotoxicity; nigrostriatal; nigrostriatal dopaminergic system; parkinsons-disease; sex; sexual differences; striatum; tamoxifen
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
17-beta-estradiol
2006
c57/b1 mice
Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, Ghb, and Substituted Amphetamines
differences
Dluzen D E
Female
gonadal steroids
inhibition
McDermott J L
mptp-induced neurotoxicity
Neurodegeneration
Neuroprotection
Neurotoxicity
nigrostriatal
nigrostriatal dopaminergic system
parkinsons-disease
sex
sexual differences
striatum
Tamoxifen
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
136-156
Volume
965
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, Anti-estrogen, And Gender - Differences In Methamphetamine Neurotoxicity
Publisher
An entity responsible for making the resource available
Cellular and Molecular Mechanisms of Drugs of Abuse Ii: Cocaine, Substituted Amphetamines, Ghb, and Opiates
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002
Subject
The topic of the resource
breast cancer; dopamine; environmental-temperature; GFAP; in-vivo; mediated neuroprotection; mptp-induced neurotoxicity; nigrostriatal; nigrostriatal dopaminergic system; PAI-1; parkinsons-disease; parkinsons-disease; rat-brain; sex-differences; sexual differences; striatal dopamine; tamoxifen; testosterone; thermoregulation
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2002
breast cancer
Cellular and Molecular Mechanisms of Drugs of Abuse Ii: Cocaine, Substituted Amphetamines, Ghb, and Opiates
Dluzen D E
Dopamine
environmental-temperature
GFAP
in-vivo
McDermott J L
mediated neuroprotection
mptp-induced neurotoxicity
nigrostriatal
nigrostriatal dopaminergic system
PAI-1
parkinsons-disease
rat-brain
sex-differences
sexual differences
striatal dopamine
Tamoxifen
Testosterone
thermoregulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(96)00934-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(96)00934-1</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
215-219
Issue
1
Volume
741
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Dublin Core
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Title
A name given to the resource
The Effects Of Intranasal Infusion Of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) Upon Catecholamine Concentrations Within Olfactory Bulbs And Corpus Striatum Of Male Mice
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-11
Subject
The topic of the resource
adult-rat; alzheimers-disease; brain; dopamine; epithelium; locus coeruleus; locus coeruleus; mouse; Neurosciences & Neurology; neurotoxicity; nigrostriatal; norepinephrine; parkinsons-disease; toxicity; transport; transporter; uptake
Creator
An entity primarily responsible for making the resource
Dluzen D E; Kefalas G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(96)00934-1" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(96)00934-1</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
adult-rat
alzheimers-disease
Brain
Brain research
Department of Internal Medicine
Dluzen D E
Dopamine
Epithelium
Kefalas G
locus coeruleus
mouse
NEOMED College of Medicine
Neurosciences & Neurology
Neurotoxicity
nigrostriatal
Norepinephrine
parkinsons-disease
toxicity
transport
transporter
uptake
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(97)00630-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(97)00630-6</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
340-344
Issue
2
Volume
767
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Dublin Core
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Title
A name given to the resource
Estrogen Decreases Corpus Striatal Neurotoxicity In Response To 6-hydroxydopamine
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
brain; c57/b1 mice; dihydroxyphenylacetic acid; dopamine; dopamine uptake sites; estradiol; female rats; mptp-induced neurotoxicity; neuroprotection; Neurosciences & Neurology; nigrostriatal; ovariectomized rats; parkinsons-disease; parkinsons-disease; progesterone; release
Creator
An entity primarily responsible for making the resource
Dluzen D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(97)00630-6" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(97)00630-6</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
Brain
Brain research
c57/b1 mice
dihydroxyphenylacetic acid
Dluzen D
Dopamine
dopamine uptake sites
estradiol
female rats
mptp-induced neurotoxicity
Neuroprotection
Neurosciences & Neurology
nigrostriatal
ovariectomized rats
parkinsons-disease
progesterone
release
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0014-2999(98)00008-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(98)00008-9</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
207-211
Issue
2
Volume
345
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Dublin Core
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Title
A name given to the resource
Inhibition Of Striatal Dopamine Transporter Activity By 17 Beta-estradiol
Publisher
An entity responsible for making the resource available
European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
brain; dopamine transporter; estradiol; estrous-cycle; gonadal steroid hormone; h-3 gbr-12935 binding; mptp-induced neurotoxicity; nigrostriatal; nucleus-accumbens; Pharmacology & Pharmacy; progesterone; protein-kinase-c; release; sex-differences; striatal; synaptosome; uptake inhibition; uptake sites
Creator
An entity primarily responsible for making the resource
Disshon K A; Boja J W; Dluzen D E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0014-2999(98)00008-9" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(98)00008-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Boja J W
Brain
Disshon K A
Dluzen D E
Dopamine transporter
estradiol
estrous-cycle
European journal of pharmacology
gonadal steroid hormone
h-3 gbr-12935 binding
mptp-induced neurotoxicity
nigrostriatal
nucleus-accumbens
Pharmacology & Pharmacy
progesterone
protein-kinase-c
release
sex-differences
striatal
synaptosome
uptake inhibition
uptake sites
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)00993-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)00993-z</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
248-252
Issue
1
Volume
698
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Dublin Core
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Title
A name given to the resource
TAMOXIFEN TREATMENT OF OVARIECTOMIZED MICE ALTERS DOPAMINE RELEASE FROM STRIATAL TISSUE FRAGMENTS SUPERFUSED IN-VITRO
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-11
Subject
The topic of the resource
rat; therapy; Neurosciences & Neurology; estrogen; metabolism; brain; breast-cancer; estradiol; nigrostriatal; pituitary; antiestrogens; uterus; anti-estrogen; caudate nucleus
Creator
An entity primarily responsible for making the resource
McDermott J L; Liu B J; Dluzen D E
Description
An account of the resource
In this report we examined the effect of tamoxifen upon the nigrostriatal dopaminergic system. Ovariectomized mice were subjected to one of the following treatments: two subcutaneous injections administered on successive days of the sesame oil vehicle (control), estradiol benzoate (EB-10 mu g), tamoxifen citrate (TMX 125 mu g) or a combination of EB + TMX. At 24 h after the second injection, the caudate nucleus was superfused in vitro to evaluate the effects of these treatments upon basal as well as potassium stimulated (30 mM) dopamine release rates. In addition, uteri were weighed from each animal. Basal and total fractional dopamine release rates from the caudate nucleus of control mice were significantly lower than those of the other three treatments, which failed to differ among each other. Potassium minus(-) basal stimulated dopamine release rates failed to differ significantly among the four treatment conditions. Uterine weights of the TMX treated mice were significantly greater than controls, but significantly lower than EB and EB + TMX animals. These data show that TMX can significantly increase caudate nucleus dopamine release to levels observed in EB treated mice. These agonistic effects of TMX upon nigrostriatal dopaminergic function can be contrasted with its relatively weak estrogenic effects upon uterine weights and indicate the discriminatory, system specific effects that can be exerted by this anti-estrogen. This demonstration of TMX's ability to modulate central nervous system function is of particular relevance in light of pending clinical trials for the prophylactic use of TMX in the treatment of women for breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(95)00993-z" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)00993-z</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
anti-estrogen
antiestrogens
Brain
Brain research
breast-cancer
caudate nucleus
Dluzen D E
estradiol
estrogen
Journal Article or Conference Abstract Publication
Liu B J
McDermott J L
Metabolism
Neurosciences & Neurology
nigrostriatal
pituitary
rat
therapy
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0197-0186(97)00086-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0197-0186(97)00086-7</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
299-307
Issue
3
Volume
32
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Dublin Core
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Title
A name given to the resource
Tamoxifen alters dopamine output through direct actions upon superfused corpus striatal tissue fragments
Publisher
An entity responsible for making the resource available
Neurochemistry International
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
breast-cancer; receptor; Biochemistry & Molecular Biology; Neurosciences & Neurology; estrogen; breast-cancer; antagonist; estradiol; nigrostriatal; release; anti-estrogen; antiestrogens; metabolites; brain metastases; sexual-behavior; non-genomic
Creator
An entity primarily responsible for making the resource
McDermott J L; Anderson L I; Dluzen D E
Description
An account of the resource
Tamoxifen (10 pg/ml) was infused directly into superfused striatal tissue fragments of ovariectomized rats for a 50 min period. Immediately following the termination of tamoxifen there was a significant increase in dopamine output compared with non-infused controls. No such significant increase was observed with use of a 100 pg/ml tamoxifen dose. Although dopamine output was again increased upon termination of a 2 h infusion of tamoxifen, these levels failed to differ significantly from that of non-infused controls. Similarly, a shorter 10 min duration infusion of tamoxifen failed to alter dopamine output. Finally, we examined whether the tamoxifen-induced, post-infusion increase in dopamine output, as observed following a 50 min infusion of 10 pg/ml, involved a calcium dependent process. To achieve this goal, superfusions were performed with Calcium/Tamoxifen, No Calcium/Tamoxifen, No Calcium/No Tamoxifen and Calcium/No Tamoxifen. A significant increase in dopamine output post-tamoxifen infusion was obtained for the Calcium/Tamoxifen condition compared with the remaining three groups which failed to differ from one another. Taken together these results show that tamoxifen can alter dopamine output through direct, non-genomic effects upon striatal neurons. Responses to this anti-estrogen are intriguing since they are apparent following removal, but not during tamoxifen infusion and represent a calcium-dependent process. These data suggest that tamoxifen may represent an important modulator of nigrostriatal dopaminergic function. (C) 1998 Elsevier Science Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0197-0186(97)00086-7" target="_blank" rel="noreferrer noopener">10.1016/s0197-0186(97)00086-7</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Anderson L I
Antagonist
anti-estrogen
antiestrogens
Biochemistry & Molecular Biology
brain metastases
breast-cancer
Dluzen D E
estradiol
estrogen
Journal Article or Conference Abstract Publication
McDermott J L
metabolites
Neurochemistry international
Neurosciences & Neurology
nigrostriatal
non-genomic
Receptor
release
sexual-behavior
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)02511-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02511-7</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
160-171
Issue
1
Volume
872
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Title
A name given to the resource
Estrogen modulates responses of striatal dopamine neurons to MPP+: evaluations using in vitro and in vivo techniques
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-07
Subject
The topic of the resource
Neurosciences & Neurology; transporter; brain; neurotoxicity; Neuroprotection; cd-1 mice; nucleus-accumbens; sex-differences; estradiol; mptp-induced neurotoxicity; nigrostriatal; release; 17-beta-estradiol; anesthetized rat; electrochemistry; rat dorsal striatum; superfusion
Creator
An entity primarily responsible for making the resource
Arvin M; Fedorkova L; Disshon K A; Dluzen D E; Leipheimer R E
Description
An account of the resource
In vitro superfusion and in vivo electrochemistry were used to investigate the role of estrogen in modulatings MPP+-induced dopamine output in the corpus striatum and nucleus accumbens of ovariectomized female rats. For in vitro superfusion experiments, dopamine and dihydroxyphenylacetic acid release were determined using HPLC with electrochemical detection from superfusion of corpus striatum fragments with Kreb's ringer phosphate buffer pulsed with MPP+ alone or MPP+ with estrogen. The in vivo electrochemistry experiments recorded the dopamine signal from carbon fiber microelectrodes stereotaxically passed through the corpus striatum and nucleus accumbens. Dopamine release was stimulated by pressure ejection of MPP+ alone or in combination with estrogen through glass micropipettes fastened to the electrodes. Dopamine output from superfusion chambers which received infusion of MPP+ with estrogen showed significantly lower output of dopamine compared with chambers which received MPP+ alone. Outputs of dihydroxyphenylacetic acid did not increase following MPP+ infusions. Data from the electrochemistry experiments demonstrated that estrogen significantly reduced both the amplitude and clearance rates of the MPP+-evokrd dopamine signal in both the corpus striatum and nucleus accumbens. Results of this study demonstrate that: (1) MPP+ evokes striatal dopamine release and this effect is significantly reduced in the presence of estrogen as determined by both in vivo electrochemistry and in vitro superfusion: (2) similar, albeit attenuated effects are observed in the nucleus accumbens as determined with in vivo electrochemistry; (3) estrogen acts to inhibit the clearance of dopamine in both the striatum and nucleus accumbens: and (4) estrogen may function as a neuroprotectant by reducing the uptake of neurotoxin into dopaminergic neurons. (C) 2000 Elsevier Science B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)02511-7" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02511-7</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
17-beta-estradiol
2000
anesthetized rat
Arvin M
Brain
Brain research
cd-1 mice
Disshon K A
Dluzen D E
Electrochemistry
estradiol
Fedorkova L
Journal Article or Conference Abstract Publication
Leipheimer R E
mptp-induced neurotoxicity
Neuroprotection
Neurosciences & Neurology
Neurotoxicity
nigrostriatal
nucleus-accumbens
rat dorsal striatum
release
sex-differences
superfusion
transporter