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Text
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URL Address
<a href="http://doi.org/10.1021/jm300100d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/jm300100d</a>
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Pages
3425-3435
Issue
7
Volume
55
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Title
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Identification of a Class of Novel Tubulin Inhibitors
Publisher
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Journal of Medicinal Chemistry
Date
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2012
2012-04
Subject
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agents; analog jcc76; biological evaluation; breast-cancer cells; halichondrin-b; heat-shock proteins; hsp27 phosphorylation; in-vivo; nimesulide; nonsteroidal antiinflammatory drugs; Pharmacology & Pharmacy; tumor-cells
Creator
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Yi X; Zhong B; Smith K M; Geldenhuys W J; Feng Y; Pink J J; Dowlati A; Xu Y; Zhou A M; Su B
Description
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We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. However, the molecular targets of these agents still remain unclear. In this study, we synthesized a biotinylated probe based on a representative molecule of the compound library and performed protein pull-down assays to purify the anticancer targets of the compound. Via proteomic approaches, the major proteins bound to the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibited tubulin polymerization by binding at the colchicine domain. However, the tubulin inhibitory effect of the compound activated the Hsp27 phosphorylation and possibly overrode the direct Hsp27 inhibitory effects, which made it difficult to solely validate the Hsp27 target. Taken together, the compound was a dual ligand of tubulin and Hsp27, inhibited tubulin polymerization, and had the potential to be a class of new chemotherapeutic agents.
Identifier
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<a href="http://doi.org/10.1021/jm300100d" target="_blank" rel="noreferrer noopener">10.1021/jm300100d</a>
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Journal Article
2012
agents
analog jcc76
biological evaluation
breast-cancer cells
Dowlati A
Feng Y
Geldenhuys W J
halichondrin-b
Heat-Shock Proteins
hsp27 phosphorylation
in-vivo
Journal Article
Journal of medicinal chemistry
nimesulide
nonsteroidal antiinflammatory drugs
Pharmacology & Pharmacy
Pink J J
Smith K M
Su B
tumor-cells
Xu Y
Yi X
Zhong B
Zhou A M