1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
250-255
Issue
4
Volume
31
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration differentially alters H-3 nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats
Publisher
An entity responsible for making the resource available
Synapse
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
androgens; cerebral-cortex; chemical cues; conspecific odors; depression; dopamine; h-3 nisoxetine; hormone-releasing hormone; induced plasticity; locus-coeruleus; memory/recognition; Neurosciences & Neurology; norepinephrine transporter; olfaction; transporter; transporter messenger-rna; tyrosine-hydroxylase
Creator
An entity primarily responsible for making the resource
Shang Y L; Boja J W; Dluzen D E
Description
An account of the resource
In the present study, [H-3]nisoxetine binding to norepinephrine (NE) uptake sites and [H-3]norepinephrine uptake were investigated within olfactory bulb (OB) and frontal cortex homogenates from intact and castrated male rats. Statistically significant reductions in the number of [H-3] nisoxetine binding sites (B-max) were found in OB from the castrates, while significantly increased B-max values were obtained in the frontal cortex. Castration also significantly altered the affinity (K-d) of [H-3]nisoxetine binding in the frontal cortex, but not in the OB. Assessment of [H-3]norepinephrine uptake showed that in neither brain regions were there any statistically significant differences in K-m nor V-max between the castrated and intact male rats, indicating that the basal uptake process is not changed following castration in either of these brain areas. These results demonstrate the differential effects of castration upon [H-3]nisoxetine binding sites between the OB and frontal cortex. Such findings provide new evidence for one of the mechanisms by which androgens may modulate central noradrenergic activity. Synapse 31:250-255, 1999. (C) 1999 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q" target="_blank" rel="noreferrer noopener">10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
androgens
Boja J W
cerebral-cortex
chemical cues
conspecific odors
Depression
Dluzen D E
Dopamine
h-3 nisoxetine
hormone-releasing hormone
induced plasticity
Journal Article
locus-coeruleus
memory/recognition
Neurosciences & Neurology
norepinephrine transporter
olfaction
Shang Y L
synapse
transporter
transporter messenger-rna
tyrosine-hydroxylase
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
9-17
Issue
1
Volume
30
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Multiple binding sites for I-125 RTI-121 and other cocaine analogs in rat frontal cerebral cortex
Publisher
An entity responsible for making the resource available
Synapse
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
Neurosciences & Neurology; localization; h-3 gbr-12935 binding; transporter; membranes; dopamine transporter; cocaine; nucleus-accumbens; norepinephrine transporter; medial prefrontal cortex; brain synaptosomes; glycosylation; human dopamine; reinforcing properties; RTI-121; self-stimulation; serotonin transporter; striatal
Creator
An entity primarily responsible for making the resource
Boja J W; Carroll F I; Vaughan R A; Kopajtic T; Kuhar M J
Description
An account of the resource
In an effort to identify novel binding sites for cocaine and its analogs, we carried out binding studies with the high-affinity and selective ligand [I-125]RTI-121 in rat frontal cortical tissue. Very low densities of binding sites were found. Saturation analysis revealed that the binding was to both high- and low-affinity sites. Pharmacological competition studies were carried out with inhibitors of the dopamine, norepinephrine, and serotonin transporters. The various transporter inhibitors inhibited the binding of 15 pM [I-125]RTI-121 in a biphasic fashion following a two-site binding model. The resultant data were complex and did not suggest a simple association with any single transporter. Correlational analysis supported the following hypothesis: [I-125] RTI-121 binds to known transporters and not to novel sites; these include dopamine, norepinephrine, and serotonin transporters. Immunoprecipitation of transporters photoaffinity labeled with [(125)] RTI-82 and subsequent analysis of SDS-page gels revealed the presence of authentic dopamine transporters in these samples; displacement of the photoaffinity label occurred with a typical dopamine transporter pharmacology. These data are compatible with the binding properties of RTI-181 and the presence of several known transporters in the tissue studied. Synapse 30:9-17, 1998. (C) 1998 Wiley-Liss, Inc.dagger
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p" target="_blank" rel="noreferrer noopener">10.1002/(sici)1098-2396(199809)30:1%3C9::aid-syn2%3E3.3.co;2-p</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Boja J W
brain synaptosomes
Carroll F I
Cocaine
Dopamine transporter
Glycosylation
h-3 gbr-12935 binding
human dopamine
Journal Article or Conference Abstract Publication
Kopajtic T
Kuhar M J
localization
medial prefrontal cortex
membranes
Neurosciences & Neurology
norepinephrine transporter
nucleus-accumbens
reinforcing properties
RTI-121
self-stimulation
serotonin transporter
striatal
synapse
transporter
Vaughan R A