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URL Address
<a href="http://doi.org/10.1006/excr.1997.3743" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/excr.1997.3743</a>
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Pages
275-284
Issue
1
Volume
236
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Title
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Ultrastructural nucleolar alterations induced by an ametantrone/polyr(A-U) complex
Publisher
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Experimental Cell Research
Date
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1997
1997-10
Subject
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actinomycin-d; Cell Biology; cells; fibrillar centers; human interferon; invitro antiviral activity; mitoxantrone; novatrone; nucleic-acids; Oncology; photodynamic therapy; poly r(a-u); rna-synthesis
Creator
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Thiry M; Jamison J M; Gilloteaux J; Summers J L; Goessens G
Description
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In the present study we examined the ultrastructural modifications as well as the precise distribution of DNA and RNA in RT4 cell nucleoli following a 3-h exposure to nontoxic or toxic doses of ametantrone (AMT), poly(adenylate-uridylate) (polyr(A-U), or an AMT/polyr(A-U) combination, While distribution of nucleic acids within the various nucleolar components is not modified following all treatments, the nucleoli exhibit several ultrastructural changes: redistribution of the nucleolar components, decrease in the number of fibrillar centers, and increase in the size of the fibrillar centers, The relative frequencies of the test agents to induce the apparition of nucleoli of compact type are AMT/polyr(A-U) > AMT approximate to polyr(A-U) > sham-treated, while the abilities of the test agents to induce the nucleolar segregation are AMT/polyr(A-U) approximate to AMT > polyr(A-U) > sham-treated cells, These ultrastructural changes are characteristic of drugs that intercalate into DNA and inhibit rDNA transcription as well as rRNA processing and release of nascent preribosomes from the nucleolus. (C) 1997 Academic Press.
Identifier
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<a href="http://doi.org/10.1006/excr.1997.3743" target="_blank" rel="noreferrer noopener">10.1006/excr.1997.3743</a>
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Journal Article
1997
actinomycin-d
Cell Biology
Cells
Experimental cell research
fibrillar centers
Gilloteaux J
Goessens G
human interferon
invitro antiviral activity
Jamison J M
Journal Article
mitoxantrone
novatrone
nucleic-acids
oncology
photodynamic therapy
poly r(a-u)
rna-synthesis
Summers J L
Thiry M