1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/jm070577s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/jm070577s</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
6501-6506
Issue
26
Volume
50
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Conformational comparisons of a series of tachykinin peptide analogs
Publisher
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Journal of Medicinal Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-12
Subject
The topic of the resource
Pharmacology & Pharmacy; escherichia-coli; nmr; dynamics; nuclear-magnetic-resonance; substance-p receptor; agonists; neuropeptides; bradykinin; molecular modeling investigations; sds micelles
Creator
An entity primarily responsible for making the resource
Beard D J; Perrine S A; Phillips E; Hoque S; Conerly S; Tichenor C; Simmons M A; Young J K
Description
An account of the resource
Previous studies have shown differences in the biological activity and the structure of two naturally occurring tachykinin peptides, substance P (SP, RPKPQQFFGLM-NH2),and ranatachykinin C (RTKC, HNPASFIGLM-NH2). To further understand the basis for these differences, four analogs that selectively incorporate the amino acid differences between SP and RTKC have been synthesized for study. The four peptide analogs studied have the following amino acid sequences: SP2-11, also known as des-Arg SP (PKPQQFFGLM-NH2); Q5A-SP (RPKPAQFFGLM-NH2); Q6S-SP (RPKPQSFFGLM-NH2); and Q5AQ6S-SP (RPKPASFFGLM-NH2). Nuclear magnetic resonance spectroscopy and molecular modeling calculations were performed on SP, RTKC, SP2-11, Q5A-SP, Q6S-SP, and Q5AQ6S-SP to compare their conformational differences and similarities in the presence of the membrane mimetic system sodium dodecyl sulfate. The molecular modeling data of the analogs Q5A-SP and Q6S-SP show residues 1-3 have a random conformation and residues 4-8 have a helical structure, while the C-terminus contains a poly C-7 conformation that is similar to SP but different from RTKC., The molecular modeling data of the analogs SP2-11 and Q5AQ6S-SP show a continuous helix conformation for residues 4-11 at the C-terminus, which is different from SP but similar to RTKC. These structural differences are related to the functional differences of binding of the peptides at the SP receptor (NK1).
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/jm070577s" target="_blank" rel="noreferrer noopener">10.1021/jm070577s</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
agonists
Beard D J
bradykinin
Conerly S
dynamics
escherichia-coli
Hoque S
Journal Article or Conference Abstract Publication
Journal of medicinal chemistry
molecular modeling investigations
neuropeptides
nmr
nuclear-magnetic-resonance
Perrine S A
Pharmacology & Pharmacy
Phillips E
sds micelles
Simmons M A
substance-p receptor
Tichenor C
Young J K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0009-3084(96)02574-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0009-3084(96)02574-1</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
147-162
Issue
2
Volume
82
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of 1-palmitoyl lysophosphatidylcholine on phase properties of 1,2-dipalmitoyl phosphatidylethanolamine: A thermodynamic and NMR study
Publisher
An entity responsible for making the resource available
Chemistry and Physics of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-08
Subject
The topic of the resource
Biophysics; Biochemistry & Molecular Biology; cholesterol; fusion; lysolecithin; lipid; membranes; bilayer; H-2-NMR; transition; nuclear-magnetic-resonance; phosphatidylcholine vesicles; lecithin; bilayers; DSC; mixtures; P-31-NMR; phosphatidylethanolamine
Creator
An entity primarily responsible for making the resource
Checchetti A; Golemme A; Chidichimo G; LaRosa C; Grasso D; Westerman P W
Description
An account of the resource
The effect of 1-palmitoyl lysophosphatidylcholine (PLPC) on the phase behaviour of 1,2-dipalmitoyl phosphatidylethanolamine (DPPE) in excess water (34 wt%) has been examined by differential scanning calorimetry, scanning dilatometry and isothermal compressibility measurements. Mole percentages of PLPC in DPPE between 14 and 62% have been studied over the temperature range 30-75 degrees C. The temperature dependence of orientational ordering at selected sites in H-2-labelled PLPC and 2H(2)O has been determined from measurement of time-averaged chemical shift anisotropies and quadrupole splittings in the P-31- and H-2-NMR spectra. These data have been used to further characterize phase behaviour. At less than equimolar contents of PLPC, when a single phase transition with a reduced transition temperature is observed, spectral and calorimetric data indicate complete miscibility of the two lipid components. An equimolar mixture of PLPC and DPPE shows a sharp first order transition at 47.3 degrees C and a second order transition at 62.5 degrees C. NMR data are consistent with the existence of a defective bilayer at intermediary temperatures. In this range it is proposed that PLPC molecules prefer regions with high curvature in the vicinity of the defects, while DPPE molecules are mostly confined to flatter regions of the bilayer. A possible molecular model is described, At temperatures above 62.5 degrees C, PLPC and DPPE are completely miscible and exist as lamellae. At higher PLPC content (> 50 mol%), thermodynamic and spectral data are indicative of phase separation of the two components over the temperature range examined.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0009-3084(96)02574-1" target="_blank" rel="noreferrer noopener">10.1016/0009-3084(96)02574-1</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
bilayer
bilayers
Biochemistry & Molecular Biology
Biophysics
Checchetti A
Chemistry and Physics of Lipids
Chidichimo G
Cholesterol
DSC
fusion
Golemme A
Grasso D
H-2-NMR
Journal Article or Conference Abstract Publication
LaRosa C
LECITHIN
lipid
lysolecithin
membranes
mixtures
nuclear-magnetic-resonance
P-31-NMR
phosphatidylcholine vesicles
phosphatidylethanolamine
transition
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0009-3084(97)00086-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0009-3084(97)00086-8</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
109-115
Issue
1
Volume
90
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
On the stability of the ripple phase in the DPPC/PLPC/water ternary system
Publisher
An entity responsible for making the resource available
Chemistry and Physics of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-11
Subject
The topic of the resource
Biophysics; Biochemistry & Molecular Biology; gel; cholesterol; lysolecithin; membranes; nuclear-magnetic-resonance; water; transition; lipid bilayers; phospholipid-bilayers; Lipids; differential scanning calorimetry (DSC); lecithin; phosphatidylcholine; phosphatidylcholine bilayers; pretransition; scanning dilatometry (SD)
Creator
An entity primarily responsible for making the resource
Checchetti A; Chidichimo G; Golemme A; Grasso D; Imbardelli D; LaRosa C; Nicoletta F P; Westerman P W
Description
An account of the resource
The effect of incorporation of 1-palmitoyl-sn-glycero-3-phosphocholine (PLPC) on the structure of the P-beta' ripple mesophase in aqueous dispersions of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) has been studied by differential scanning calorimetry (DSC) and scanning dilatometry (SD). For samples containing 34 wt. % (H2O)-H-2 and 0-15 wt. % PLPC, a pretransition was observed by DSC. The pretransition disappears at 15 wt. % PLPC. The behavior of thermodynamic functions at the pretransition and main transition gives new insights on the structural changes produced by PLPC on bilayers of DPPC. (C) 1997 Elsevier Science Ireland Ltd.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0009-3084(97)00086-8" target="_blank" rel="noreferrer noopener">10.1016/s0009-3084(97)00086-8</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
Biochemistry & Molecular Biology
Biophysics
Checchetti A
Chemistry and Physics of Lipids
Chidichimo G
Cholesterol
differential scanning calorimetry (DSC)
Gel
Golemme A
Grasso D
Imbardelli D
Journal Article or Conference Abstract Publication
LaRosa C
LECITHIN
Lipid Bilayers
Lipids
lysolecithin
membranes
Nicoletta F P
nuclear-magnetic-resonance
phosphatidylcholine
phosphatidylcholine bilayers
phospholipid-bilayers
pretransition
scanning dilatometry (SD)
transition
Water
Westerman P W