1
40
2
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Text
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URL Address
<a href="http://doi.org/10.3389/fnins.2014.00290" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnins.2014.00290</a>
Pages
290–290
Volume
8
Dublin Core
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Title
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Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.
Publisher
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Frontiers in neuroscience
Date
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2014
1905-07
Subject
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glaucoma; optic nerve; axonal transport; axonopathy; neurodegeneration; ocular; superior colliculi; vision disorders
Creator
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Dengler-Crish Christine M; Smith Matthew A; Inman Denise M; Wilson Gina N; Young Jesse W; Crish Samuel D
Description
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Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood. Previous work suggests that anterograde transport is affected earlier and to a larger degree than retrograde transport, yet this has never been examined directly in vivo. Using combined anterograde and retrograde tract tracing methods, we examined the time-course of anterograde and retrograde transport deficits in the retinofugal projection in pre-glaucomatous (3 month-old) and glaucomatous (9-13 month old) DBA/2J mice. DBA/2J-Gpnmb (+) mice were used as a control strain and were shown to have similar retinal ganglion cell densities as C57BL/6J control mice-a strain commonly investigated in the field of vision research. Using cholera toxin-B injections into the eye and FluoroGold injections into the superior colliculus (SC), we were able to measure anterograde and retrograde transport in the primary visual projection. In DBA/2J, anterograde transport from the retina to SC was decreased by 69% in the 9-10 month-old age group, while retrograde transport was only reduced by 23% from levels seen in pre-glaucomatous mice. Despite this minor reduction, retrograde transport remained largely intact in these glaucomatous age groups until 13-months of age. These findings indicate that axonal transport deficits occur in semi-functional axons that are still connected to their brain targets. Structural persistence as determined by presence of estrogen-related receptor beta label in the superficial SC was maintained beyond time-points where reductions in retrograde transport occurred, also supporting that transport deficits may be due to physiological or functional abnormalities as opposed to overt structural loss.
Identifier
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<a href="http://doi.org/10.3389/fnins.2014.00290" target="_blank" rel="noreferrer noopener">10.3389/fnins.2014.00290</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Axonal Transport
Axonopathy
Crish Samuel D
Dengler-Crish Christine M
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Frontiers in neuroscience
Glaucoma
Inman Denise M
NEOMED College of Medicine
NEOMED College of Pharmacy
Neurodegeneration
ocular
optic nerve
Smith Matthew A
superior colliculi
vision disorders
Wilson Gina N
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/ICO.0b013e3181ee67fd" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/ICO.0b013e3181ee67fd</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
360-363
Issue
3
Volume
30
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Copper Deposition In A Variant Of Multiple Myeloma: Pathologic Changes In The Cornea And The Lens Capsule
Publisher
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Cornea
Date
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2011
2011-03
Subject
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central defect; copper deposition; deposition; Descemet membrane; descemets membrane; hypercupremia; immunoglobulin; leukomas; monoclonal gammopathy; multiple myeloma; ocular; Ophthalmology; true exfoliation; wilsons-disease
Creator
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Edward D P; Patil A J; Sugar J; Parikh M
Identifier
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<a href="http://doi.org/10.1097/ICO.0b013e3181ee67fd" target="_blank" rel="noreferrer noopener">10.1097/ICO.0b013e3181ee67fd</a>
Format
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Journal Article or Conference Abstract Publication
2011
central defect
copper deposition
Cornea
deposition
Descemet membrane
descemets membrane
Edward D P
hypercupremia
immunoglobulin
leukomas
monoclonal gammopathy
multiple myeloma
ocular
Ophthalmology
Parikh M
Patil A J
Sugar J
true exfoliation
wilsons-disease